BDBM50553403 CHEMBL4747929

SMILES COc1nc(nc(N)c1C(=O)NCc1c(Cl)cccc1Cl)-c1ncco1

InChI Key InChIKey=MZALOVKMJUTVDD-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50553403   

TargetAdenosine receptor A2a(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50553403(CHEMBL4747929)
Affinity DataKi:  0.0780nMAssay Description:Inhibition of FRET-labelled CA200645 binding to human adenosine 2A receptor expressed in CHO cells incubated for 2 hr by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50553403(CHEMBL4747929)
Affinity DataKi:  5.40nMAssay Description:Inhibition of FRET-labelled CA200645 binding to human adenosine 2B receptor expressed in CHO cells incubated for 2 hr by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50553403(CHEMBL4747929)
Affinity DataIC50:  17nMAssay Description:Antagonist activity at adenosine 2A receptor in human whole blood assessed as reduction in phosphorylated CREB level preincubated for 20 mins followe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50553403(CHEMBL4747929)
Affinity DataIC50: >200nMAssay Description:Antagonist activity at adenosine 2A receptor in human blood assessed as reversal of NECA/LPS-stimulated TNF-alpha release incubated for 5 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed