BDBM60978 6-Chloro-5-(4-methoxyphenyl)-1H-indazole-3-carboxylic acid::US9394285, 97

SMILES COc1ccc(cc1)-c1cc2c(n[nH]c2cc1Cl)C(O)=O

InChI Key InChIKey=WXDKLJLSBMTTFY-UHFFFAOYSA-N

Data  1 Kd  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 60978   

LigandPNGBDBM60978(6-Chloro-5-(4-methoxyphenyl)-1H-indazole-3-carboxy...)
Affinity DataEC50:  202nMpH: 7.5 T: 2°CAssay Description:The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM60978(6-Chloro-5-(4-methoxyphenyl)-1H-indazole-3-carboxy...)
Affinity DataKd:  1.78E+3nMAssay Description:Binding affinity to recombinant human AMPK alpha1/beta1/gamma1 by SPR binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM60978(6-Chloro-5-(4-methoxyphenyl)-1H-indazole-3-carboxy...)
Affinity DataEC50:  323nMAssay Description:Activation of recombinant human AMPK alpha1/beta1/gamma1 using Cy5-labelled SAMS as substrate assessed as protection from Thr172 residue dephosphoryl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed