BDBM7977 (3S,4S)-5-[(4-bromophenyl)methoxy]-N-[(1S)-1-{[(1S)-1-carbamoyl-3-methylbutyl]carbamoyl}ethyl]-3-hydroxy-4-[(2S)-3-methyl-2-(pyridin-2-ylformamido)butanamido]pentanamide::CHEMBL112598::Pyridine-2-carboxylic Acid ((S)-1-{(1S,2S)-1-(4-Bromobenzyloxymethyl)3-[(S)-1-((S)-1-carbamoyl-3-methyl-butylcarbamoyl)ethylcarbamoyl]-2-hydroxypropylcarbamoyl}-2-methylpropyl)amide::Statine-like inhibitor 16

SMILES CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)C[C@H](O)[C@H](COCc1ccc(Br)cc1)NC(=O)[C@@H](NC(=O)c1ccccn1)C(C)C)C(N)=O

InChI Key InChIKey=QXHNYZQKWOKULQ-QPGFMSSHSA-N

Data  7 KI

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 7977   

TargetPlasmepsin I(Plasmodium falciparum)
LinköPing University

Curated by ChEMBL
LigandPNGBDBM7977((3S,4S)-5-[(4-bromophenyl)methoxy]-N-[(1S)-1-{[(1S...)
Affinity DataKi:  0.5nMAssay Description:Inhibitory concentration against the Plasmepsin I of Plasmodium falciparumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin I(Plasmodium falciparum)
LinköPing University

Curated by ChEMBL
LigandPNGBDBM7977((3S,4S)-5-[(4-bromophenyl)methoxy]-N-[(1S)-1-{[(1S...)
Affinity DataKi:  0.5nMAssay Description:Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM7977((3S,4S)-5-[(4-bromophenyl)methoxy]-N-[(1S)-1-{[(1S...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of Plasmodium falciparum plasmepsin 2More data for this Ligand-Target Pair
TargetPlasmepsin II(Plasmodium falciparum)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM7977((3S,4S)-5-[(4-bromophenyl)methoxy]-N-[(1S)-1-{[(1S...)
Affinity DataKi:  2.20nM ΔG°:  -11.7kcal/molepH: 4.5 T: 2°CAssay Description:Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...More data for this Ligand-Target Pair
TargetPlasmepsin II(Plasmodium falciparum)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM7977((3S,4S)-5-[(4-bromophenyl)methoxy]-N-[(1S)-1-{[(1S...)
Affinity DataKi:  2.20nMAssay Description:Inhibitory concentration against the Plasmepsin II of Plasmodium falciparumMore data for this Ligand-Target Pair
TargetCathepsin D(Homo sapiens (Human))
Linkoping University

LigandPNGBDBM7977((3S,4S)-5-[(4-bromophenyl)methoxy]-N-[(1S)-1-{[(1S...)
Affinity DataKi:  4.90nMAssay Description:Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Linkoping University

LigandPNGBDBM7977((3S,4S)-5-[(4-bromophenyl)methoxy]-N-[(1S)-1-{[(1S...)
Affinity DataKi:  4.90nMAssay Description:Inhibitory concentration against the human Cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed