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BDBM81464 2-[(4-chlorophenyl)-(2-pyridyl)methoxy]ethyl-dimethyl-amine;fumaric acid::CAS_486-16-8::Carbinoxamine::NSC_2564

SMILES: CN(C)CCOC(c1ccc(Cl)cc1)c1ccccn1

InChI Key: InChIKey=OJFSXZCBGQGRNV-UHFFFAOYSA-N

Data: 2 KI  2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 81464   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine H1 receptor


(RAT)
BDBM81464
PNG
(2-[(4-chlorophenyl)-(2-pyridyl)methoxy]ethyl-dimet...)
Show SMILES CN(C)CCOC(c1ccc(Cl)cc1)c1ccccn1
Show InChI InChI=1S/C16H19ClN2O/c1-19(2)11-12-20-16(15-5-3-4-10-18-15)13-6-8-14(17)9-7-13/h3-10,16H,11-12H2,1-2H3
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Article
PubMed
2.30n/an/an/an/an/an/an/an/a



TBA

Curated by PDSP Ki Database




Proc Natl Acad Sci U S A 75: 6290-4 (1978)


Article DOI: 10.1073/pnas.75.12.6290
BindingDB Entry DOI: 10.7270/Q2FN14P6
More data for this
Ligand-Target Pair
Voltage-dependent L-type calcium channel subunit alpha-1S


(Rattus norvegicus)
BDBM81464
PNG
(2-[(4-chlorophenyl)-(2-pyridyl)methoxy]ethyl-dimet...)
Show SMILES CN(C)CCOC(c1ccc(Cl)cc1)c1ccccn1
Show InChI InChI=1S/C16H19ClN2O/c1-19(2)11-12-20-16(15-5-3-4-10-18-15)13-6-8-14(17)9-7-13/h3-10,16H,11-12H2,1-2H3
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PubMed
1.08E+3n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Perugia

Curated by ChEMBL


Assay Description
Displacement of [3H]diltiazem from L-type calcium channel in Sprague-Dawley rat cardiac myocytes


J Med Chem 51: 5552-65 (2008)


BindingDB Entry DOI: 10.7270/Q24T6N5H
More data for this
Ligand-Target Pair
Bile salt export pump


(Homo sapiens (Human))
BDBM81464
PNG
(2-[(4-chlorophenyl)-(2-pyridyl)methoxy]ethyl-dimet...)
Show SMILES CN(C)CCOC(c1ccc(Cl)cc1)c1ccccn1
Show InChI InChI=1S/C16H19ClN2O/c1-19(2)11-12-20-16(15-5-3-4-10-18-15)13-6-8-14(17)9-7-13/h3-10,16H,11-12H2,1-2H3
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Article
PubMed
n/an/a>1.00E+6n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...


Drug Metab Dispos 40: 2332-41 (2012)


Article DOI: 10.1124/dmd.112.047068
BindingDB Entry DOI: 10.7270/Q2ZP488M
More data for this
Ligand-Target Pair
Chain A, Crystal Structure Of The B1b2 Domains From Human Neuropilin- 1


(Homo sapiens (Human))
BDBM81464
PNG
(2-[(4-chlorophenyl)-(2-pyridyl)methoxy]ethyl-dimet...)
Show SMILES CN(C)CCOC(c1ccc(Cl)cc1)c1ccccn1
Show InChI InChI=1S/C16H19ClN2O/c1-19(2)11-12-20-16(15-5-3-4-10-18-15)13-6-8-14(17)9-7-13/h3-10,16H,11-12H2,1-2H3
PDB
MMDB

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PCBioAssay
n/an/a>9.50E+4n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay




PubChem Bioassay (2012)


BindingDB Entry DOI: 10.7270/Q2HM5725
More data for this
Ligand-Target Pair