BDBM85511 CAS_74103-07-4::KETOROLAC::Ketorolac tris salt::Toradol
SMILES OC(=O)C1CCn2c1ccc2C(=O)c1ccccc1
InChI Key InChIKey=OZWKMVRBQXNZKK-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 25 hits for monomerid = 85511
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry
Curated by PDSP Ki Database
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry
Curated by PDSP Ki Database
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry
Curated by PDSP Ki Database
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry
Curated by PDSP Ki Database
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry
Curated by PDSP Ki Database
Affinity DataKi: 9.40E+3nM ΔG°: -13.0kcal/moleT: 2°CAssay Description:Briefly, steady-state fluorescence spectra of ANS binding was monitored by measuring the increase in fluorescence signal between 450?550 nm following...More data for this Ligand-Target Pair
3D Structure (crystal)TargetFatty acid-binding protein, liver(Rattus norvegicus (Rat))
Monash University (Parkville Campus)
Curated by ChEMBL
Monash University (Parkville Campus)
Curated by ChEMBL
Affinity DataKi: 1.16E+4nMAssay Description:Displacement of 1-anilinonaphthalene-8-sulphonic acid from rat recombinant L-FABP high binding affinity site expressed in Escherichia coli BL21 by co...More data for this Ligand-Target Pair
TargetFatty acid-binding protein, liver(Rattus norvegicus (Rat))
Monash University (Parkville Campus)
Curated by ChEMBL
Monash University (Parkville Campus)
Curated by ChEMBL
Affinity DataKi: 1.19E+5nMAssay Description:Displacement of 1-anilinonaphthalene-8-sulphonic acid from rat recombinant L-FABP low binding affinity site expressed in Escherichia coli BL21 by com...More data for this Ligand-Target Pair
Affinity DataKi: 2.08E+5nMAssay Description:Binding affinity towards human serum albuminMore data for this Ligand-Target Pair
TargetCell division control protein 42 homolog/Ras-related C3 botulinum toxin substrate 1(Homo sapiens (Human))
Kagoshima University
Curated by ChEMBL
Kagoshima University
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of RAC1/CDC42 in human ovarian cancer cellsMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PAK 1(Homo sapiens (Human))
Kagoshima University
Curated by ChEMBL
Kagoshima University
Curated by ChEMBL
Affinity DataIC50: 3.60E+4nMAssay Description:Inhibition of PAK1 in human A549 cells using myelin basic protein as substrate preincubated for 24 hrs followed by PAK1 immunoprecipation and substra...More data for this Ligand-Target Pair
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 140nMAssay Description:Inhibition of recombinant human COX2 using arachidonic acid as substrate measured after 2 to 5 minsMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 6.05E+4nMAssay Description:Instantaneous inhibition of human COX2 measured immediately after incubation of enzyme with compoundMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 120nMAssay Description:Inhibition of human COX2 measured after pre-incubation of enzyme with compoundMore data for this Ligand-Target Pair
Affinity DataIC50: 850nMpH: 7.4Assay Description:Experiments were performed in a 384-well format (Greiner no. 781207) as per the conditions noted here. Caspase-1: 2.5 nM enzyme, 6.5 mM WEHD substrat...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMpH: 7.4Assay Description:Experiments were performed in a 384-well format (Greiner no. 781207) as per the conditions noted here. Caspase-1: 2.5 nM enzyme, 6.5 mM WEHD substrat...More data for this Ligand-Target Pair
Affinity DataIC50: 860nMpH: 7.4Assay Description:Experiments were performed in a 384-well format (Greiner no. 781207) as per the conditions noted here. Caspase-1: 2.5 nM enzyme, 6.5 mM WEHD substrat...More data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+3nMpH: 7.4Assay Description:Experiments were performed in a 384-well format (Greiner no. 781207) as per the conditions noted here. Caspase-1: 2.5 nM enzyme, 6.5 mM WEHD substrat...More data for this Ligand-Target Pair
Affinity DataIC50: 1.80E+4nMpH: 7.4Assay Description:Experiments were performed in a 384-well format (Greiner no. 781207) as per the conditions noted here. Caspase-1: 2.5 nM enzyme, 6.5 mM WEHD substrat...More data for this Ligand-Target Pair
Affinity DataKd: 5.67E+4nMpH: 8.0 T: 2°CAssay Description:ITC experiments were carried out using an iTC200 microcalorimeter (MicroCal) with coin shaped sample cell (200 μL) at 37 C with stirring at 1000...More data for this Ligand-Target Pair
Affinity DataIC50: 230nMAssay Description:Concentration required to inhibit 50% activity of prostaglandin synthetase was determined in vitro in mouse brain microsomesMore data for this Ligand-Target Pair
Activity Spreadsheet -- ITC Data from BindingDB
Found 1 hit for monomerid = 85511
ITC DataΔG°: -6.02kcal/mole −TΔS°: -6.09kcal/mole ΔH°: 0.0717kcal/mole logk: 1.76E+4
pH: 8.0 T: 37.00°C
pH: 8.0 T: 37.00°C