BDBM8733 (2E)-N-methyl-N-[(1-methyl-1H-indol-3-yl)methyl]-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)prop-2-enamide::(E)-N-Methyl-N-(1-methyl-1H-indol-3-ylmethyl)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylamide::indole naphthyridinone 29

SMILES CN(Cc1cn(C)c2ccccc12)C(=O)\C=C\c1cnc2NC(=O)CCc2c1

InChI Key InChIKey=VAZMNDXVXVUKFY-JXMROGBWSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 8733   

TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus)
Glaxosmithkline

LigandPNGBDBM8733((2E)-N-methyl-N-[(1-methyl-1H-indol-3-yl)methyl]-3...)
Affinity DataIC50:  130nMpH: 6.5 T: 2°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-2-enoyl-ACP reductase II(Streptococcus pneumoniae)
Glaxosmithkline

LigandPNGBDBM8733((2E)-N-methyl-N-[(1-methyl-1H-indol-3-yl)methyl]-3...)
Affinity DataIC50:  5.00E+3nMT: 2°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADH] FabI(Haemophilus influenzae)
Glaxosmithkline

LigandPNGBDBM8733((2E)-N-methyl-N-[(1-methyl-1H-indol-3-yl)methyl]-3...)
Affinity DataIC50:  390nMT: 2°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADH] FabI(Escherichia coli)
Glaxosmithkline

LigandPNGBDBM8733((2E)-N-methyl-N-[(1-methyl-1H-indol-3-yl)methyl]-3...)
Affinity DataIC50:  70nMpH: 6.5 T: 2°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair