BDBM98990 US8497265, 446

SMILES Nc1ncc2cc(ccc2n1)-c1nccnc1OC1CN(C1)c1ccc2ccccc2n1

InChI Key InChIKey=YWLVSEKLYMROTP-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 98990   

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Amgen

US Patent
LigandPNGBDBM98990(US8497265, 446)
Affinity DataIC50:  3.30nMAssay Description:Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif). More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM98990(US8497265, 446)
Affinity DataIC50:  6.80nMAssay Description:Inhibition of human PDE10A2 using FAM-cAMP substrate by TR-FRET progressive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM98990(US8497265, 446)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human PDE11A4 using FAM-cAMP substrate by TR-FRET progressive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM98990(US8497265, 446)
Affinity DataIC50:  6.80E+3nMAssay Description:Inhibition of human PDE10A using FAM-cAMP substrate by TR-FRET progressive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM98990(US8497265, 446)
Affinity DataIC50:  503nMAssay Description:Inhibition of human PDE1B using FAM-cAMP substrate by TR-FRET progressive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM98990(US8497265, 446)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human PDE9A2 using FAM-cGMP substrate by TR-FRET progressive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM98990(US8497265, 446)
Affinity DataIC50:  208nMAssay Description:Inhibition of human PDE3A using FAM-cAMP substrate by TR-FRET progressive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM98990(US8497265, 446)
Affinity DataIC50:  581nMAssay Description:Inhibition of human PDE4D2 using FAM-cAMP substrate by TR-FRET progressive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM98990(US8497265, 446)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human PDE5A using FAM-cGMP substrate by TR-FRET progressive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM98990(US8497265, 446)
Affinity DataIC50:  1.17E+3nMAssay Description:Inhibition of human PDE7A1 using FAM-cAMP substrate by TR-FRET progressive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM98990(US8497265, 446)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human PDE8A1 using FAM-cAMP substrate by TR-FRET progressive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM98990(US8497265, 446)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human PDE2A1 using FAM-cAMP substrate by TR-FRET progressive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed