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Found 506 Enz. Inhib. hit(s) with Target = 'Monoacylglycerol lipase ABHD6'
TargetMonoacylglycerol lipase ABHD6(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50048620(CHEMBL3319620)
Affinity DataKi:  800nMAssay Description:Inhibition of human ABHD6 expressed in HEK293T cell membranes assessed as reduction in glycerol production using 2-arachidonoyl glycerol substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoacylglycerol lipase ABHD6(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50048620(CHEMBL3319620)
Affinity DataKi:  800nMAssay Description:Inhibition of ABHD6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoacylglycerol lipase ABHD6(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50048618(CHEMBL3319622)
Affinity DataKi:  2.70E+3nMAssay Description:Inhibition of human ABHD6 expressed in HEK293T cell membranes assessed as reduction in glycerol production using 2-arachidonoyl glycerol substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoacylglycerol lipase ABHD6(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50048621(CHEMBL3319619)
Affinity DataKi:  1.83E+4nMAssay Description:Inhibition of human ABHD6 expressed in HEK293T cell membranes assessed as reduction in glycerol production using 2-arachidonoyl glycerol substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoacylglycerol lipase ABHD6(Mus musculus (mouse))
The Scripps Research Institute

LigandPNGBDBM26736(CHEMBL509860 | LY2183240 | N,N-dimethyl-5-[(4-phen...)
Affinity DataIC50:  0.0900nMpH: 7.4 T: 2°CAssay Description:Serine hydrolase targets were recombinantly expressed in COS-7 cells by transient transfection. IC50 values were obtained by competitive ABPP with F...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoacylglycerol lipase ABHD6(Mus musculus (mouse))
The Scripps Research Institute

LigandPNGBDBM50010335(CHEMBL3263577)
Affinity DataIC50:  0.200nMAssay Description:In situ inhibition of ABHD6 in mouse Neuro2a cells after 4 hrs by ABPP-SILAC-based LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoacylglycerol lipase ABHD6(Mus musculus (mouse))
The Scripps Research Institute

LigandPNGBDBM50010337(CHEMBL3263582)
Affinity DataIC50:  0.200nMAssay Description:In situ inhibition of ABHD6 in mouse Neuro2a cells after 4 hrs by ABPP-SILAC-based LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoacylglycerol lipase ABHD6(Mus musculus (mouse))
The Scripps Research Institute

LigandPNGBDBM50010336(CHEMBL3263579)
Affinity DataIC50:  0.200nMAssay Description:In situ inhibition of ABHD6 in mouse Neuro2a cells after 4 hrs by ABPP-SILAC-based LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoacylglycerol lipase ABHD6(Mus musculus (mouse))
The Scripps Research Institute

LigandPNGBDBM50010336(CHEMBL3263579)
Affinity DataIC50:  0.210nMAssay Description:In situ inhibition of ABHD6 in mouse Neuro2a cells after 4 hrs by gel-based competitive ABPP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoacylglycerol lipase ABHD6(Mus musculus (mouse))
The Scripps Research Institute

LigandPNGBDBM50010335(CHEMBL3263577)
Affinity DataIC50:  0.240nMAssay Description:In situ inhibition of ABHD6 in mouse Neuro2a cells after 4 hrs by gel-based competitive ABPP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoacylglycerol lipase ABHD6(Mus musculus (mouse))
The Scripps Research Institute

LigandPNGBDBM50010337(CHEMBL3263582)
Affinity DataIC50:  0.310nMAssay Description:In situ inhibition of ABHD6 in mouse Neuro2a cells after 4 hrs by gel-based competitive ABPP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoacylglycerol lipase ABHD6(Mus musculus (mouse))
The Scripps Research Institute

LigandPNGBDBM50010337(CHEMBL3263582)
Affinity DataIC50:  0.820nMAssay Description:Inhibition of ABHD6 in FP-rhodamine-labelled mouse brain membrane preincubated for 30 mins followed by FP-rhodamine labelling measured after 30 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoacylglycerol lipase ABHD6 [33-337](Homo sapiens (Human))
Ono Pharmaceutical Co.

US Patent
LigandPNGBDBM645031(US20240010658, Example 15)
Affinity DataIC50:  1nMAssay Description:First, 1-arachidonoyl glycerol (Cayman Chemical) as a substrate was prepared with an assay buffer containing 50 mM tris-HCl (pH 7.4), 100 mM NaCl, an...More data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand Info
In DepthDetails US Patent
TargetMonoacylglycerol lipase ABHD6 [33-337](Homo sapiens (Human))
Ono Pharmaceutical Co.

US Patent
LigandPNGBDBM645032(US20240010658, Example 16)
Affinity DataIC50:  1nMAssay Description:First, 1-arachidonoyl glycerol (Cayman Chemical) as a substrate was prepared with an assay buffer containing 50 mM tris-HCl (pH 7.4), 100 mM NaCl, an...More data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand Info
In DepthDetails US Patent
TargetMonoacylglycerol lipase ABHD6 [33-337](Homo sapiens (Human))
Ono Pharmaceutical Co.

US Patent
LigandPNGBDBM645030(US20240010658, Example 12)
Affinity DataIC50:  1nMAssay Description:First, 1-arachidonoyl glycerol (Cayman Chemical) as a substrate was prepared with an assay buffer containing 50 mM tris-HCl (pH 7.4), 100 mM NaCl, an...More data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand Info
In DepthDetails US Patent
TargetMonoacylglycerol lipase ABHD6 [33-337](Homo sapiens (Human))
Ono Pharmaceutical Co.

US Patent
LigandPNGBDBM645029(US20240010658, Example 10)
Affinity DataIC50: <1nMAssay Description:First, 1-arachidonoyl glycerol (Cayman Chemical) as a substrate was prepared with an assay buffer containing 50 mM tris-HCl (pH 7.4), 100 mM NaCl, an...More data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand Info
In DepthDetails US Patent
TargetMonoacylglycerol lipase ABHD6 [33-337](Homo sapiens (Human))
Ono Pharmaceutical Co.

US Patent
LigandPNGBDBM645027(US20240010658, Example 8-1)
Affinity DataIC50:  1nMAssay Description:First, 1-arachidonoyl glycerol (Cayman Chemical) as a substrate was prepared with an assay buffer containing 50 mM tris-HCl (pH 7.4), 100 mM NaCl, an...More data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand Info
In DepthDetails US Patent
TargetMonoacylglycerol lipase ABHD6 [33-337](Homo sapiens (Human))
Ono Pharmaceutical Co.

US Patent
LigandPNGBDBM645026(US20240010658, Example 6-2)
Affinity DataIC50:  1nMAssay Description:First, 1-arachidonoyl glycerol (Cayman Chemical) as a substrate was prepared with an assay buffer containing 50 mM tris-HCl (pH 7.4), 100 mM NaCl, an...More data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand Info
In DepthDetails US Patent
TargetMonoacylglycerol lipase ABHD6 [33-337](Homo sapiens (Human))
Ono Pharmaceutical Co.

US Patent
LigandPNGBDBM645017(US20240010658, Example 2-1)
Affinity DataIC50:  1nMAssay Description:First, 1-arachidonoyl glycerol (Cayman Chemical) as a substrate was prepared with an assay buffer containing 50 mM tris-HCl (pH 7.4), 100 mM NaCl, an...More data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand Info
In DepthDetails US Patent
TargetMonoacylglycerol lipase ABHD6 [33-337](Homo sapiens (Human))
Ono Pharmaceutical Co.

US Patent
LigandPNGBDBM645024(US20240010658, Example 5)
Affinity DataIC50:  1nMAssay Description:First, 1-arachidonoyl glycerol (Cayman Chemical) as a substrate was prepared with an assay buffer containing 50 mM tris-HCl (pH 7.4), 100 mM NaCl, an...More data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand Info
In DepthDetails US Patent
TargetMonoacylglycerol lipase ABHD6 [33-337](Homo sapiens (Human))
Ono Pharmaceutical Co.

US Patent
LigandPNGBDBM645023(US20240010658, Example 3-10)
Affinity DataIC50:  1nMAssay Description:First, 1-arachidonoyl glycerol (Cayman Chemical) as a substrate was prepared with an assay buffer containing 50 mM tris-HCl (pH 7.4), 100 mM NaCl, an...More data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand Info
In DepthDetails US Patent
TargetMonoacylglycerol lipase ABHD6 [33-337](Homo sapiens (Human))
Ono Pharmaceutical Co.

US Patent
LigandPNGBDBM645022(US20240010658, Example 3-9)
Affinity DataIC50:  1nMAssay Description:First, 1-arachidonoyl glycerol (Cayman Chemical) as a substrate was prepared with an assay buffer containing 50 mM tris-HCl (pH 7.4), 100 mM NaCl, an...More data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand Info
In DepthDetails US Patent
TargetMonoacylglycerol lipase ABHD6 [33-337](Homo sapiens (Human))
Ono Pharmaceutical Co.

US Patent
LigandPNGBDBM645016(US20240010658, Example 2)
Affinity DataIC50: <1nMAssay Description:First, 1-arachidonoyl glycerol (Cayman Chemical) as a substrate was prepared with an assay buffer containing 50 mM tris-HCl (pH 7.4), 100 mM NaCl, an...More data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand Info
In DepthDetails US Patent
TargetMonoacylglycerol lipase ABHD6 [33-337](Homo sapiens (Human))
Ono Pharmaceutical Co.

US Patent
LigandPNGBDBM645015(US20240010658, Example 1-4)
Affinity DataIC50:  1nMAssay Description:First, 1-arachidonoyl glycerol (Cayman Chemical) as a substrate was prepared with an assay buffer containing 50 mM tris-HCl (pH 7.4), 100 mM NaCl, an...More data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand Info
In DepthDetails US Patent
TargetMonoacylglycerol lipase ABHD6 [33-337](Homo sapiens (Human))
Ono Pharmaceutical Co.

US Patent
LigandPNGBDBM645013(US20240010658, Example 1)
Affinity DataIC50:  1nMAssay Description:First, 1-arachidonoyl glycerol (Cayman Chemical) as a substrate was prepared with an assay buffer containing 50 mM tris-HCl (pH 7.4), 100 mM NaCl, an...More data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand Info
In DepthDetails US Patent
TargetMonoacylglycerol lipase ABHD6 [33-337](Homo sapiens (Human))
Ono Pharmaceutical Co.

US Patent
LigandPNGBDBM645014(US20240010658, Example 1-2)
Affinity DataIC50:  1nMAssay Description:First, 1-arachidonoyl glycerol (Cayman Chemical) as a substrate was prepared with an assay buffer containing 50 mM tris-HCl (pH 7.4), 100 mM NaCl, an...More data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand Info
In DepthDetails US Patent
TargetMonoacylglycerol lipase ABHD6(Mus musculus (mouse))
The Scripps Research Institute

LigandPNGBDBM50010336(CHEMBL3263579)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of ABHD6 in FP-rhodamine-labelled mouse brain membrane preincubated for 30 mins followed by FP-rhodamine labelling measured after 30 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoacylglycerol lipase ABHD6(Mus musculus (mouse))
The Scripps Research Institute

LigandPNGBDBM50010335(CHEMBL3263577)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of ABHD6 in FP-rhodamine-labelled mouse brain membrane preincubated for 30 mins followed by FP-rhodamine labelling measured after 30 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoacylglycerol lipase ABHD6 [33-337](Homo sapiens (Human))
Ono Pharmaceutical Co.

US Patent
LigandPNGBDBM645028(US20240010658, Example 9)
Affinity DataIC50:  2nMAssay Description:First, 1-arachidonoyl glycerol (Cayman Chemical) as a substrate was prepared with an assay buffer containing 50 mM tris-HCl (pH 7.4), 100 mM NaCl, an...More data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand Info
In DepthDetails US Patent
TargetMonoacylglycerol lipase ABHD6 [33-337](Homo sapiens (Human))
Ono Pharmaceutical Co.

US Patent
LigandPNGBDBM645025(US20240010658, Example 6)
Affinity DataIC50:  2nMAssay Description:First, 1-arachidonoyl glycerol (Cayman Chemical) as a substrate was prepared with an assay buffer containing 50 mM tris-HCl (pH 7.4), 100 mM NaCl, an...More data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand Info
In DepthDetails US Patent
TargetMonoacylglycerol lipase ABHD6 [33-337](Homo sapiens (Human))
Ono Pharmaceutical Co.

US Patent
LigandPNGBDBM645021(US20240010658, Example 3-6)
Affinity DataIC50:  2nMAssay Description:First, 1-arachidonoyl glycerol (Cayman Chemical) as a substrate was prepared with an assay buffer containing 50 mM tris-HCl (pH 7.4), 100 mM NaCl, an...More data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand Info
In DepthDetails US Patent
TargetMonoacylglycerol lipase ABHD6 [33-337](Homo sapiens (Human))
Ono Pharmaceutical Co.

US Patent
LigandPNGBDBM645019(US20240010658, Example 2-14)
Affinity DataIC50:  2nMAssay Description:First, 1-arachidonoyl glycerol (Cayman Chemical) as a substrate was prepared with an assay buffer containing 50 mM tris-HCl (pH 7.4), 100 mM NaCl, an...More data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand Info
In DepthDetails US Patent
TargetMonoacylglycerol lipase ABHD6 [33-337](Homo sapiens (Human))
Ono Pharmaceutical Co.

US Patent
LigandPNGBDBM645018(US20240010658, Example 2-6)
Affinity DataIC50:  2nMAssay Description:First, 1-arachidonoyl glycerol (Cayman Chemical) as a substrate was prepared with an assay buffer containing 50 mM tris-HCl (pH 7.4), 100 mM NaCl, an...More data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand Info
In DepthDetails US Patent
TargetMonoacylglycerol lipase ABHD6(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50211257(CHEMBL3895863 | US10583137, Compound 14)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of human ABHD6 using 2-AG as natural substrate by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoacylglycerol lipase ABHD6(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50211266(CHEMBL3906477)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of human ABHD6 using 2-AG as natural substrate by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoacylglycerol lipase ABHD6(Mus musculus (mouse))
The Scripps Research Institute

LigandPNGBDBM50010337(CHEMBL3263582)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of recombinant mouse ABHD6 expressed in HEK293T using 2-arachidonoylglycerol preincubated for 30 mins followed by substrate addition measu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoacylglycerol lipase ABHD6 [33-337](Homo sapiens (Human))
Ono Pharmaceutical Co.

US Patent
LigandPNGBDBM645020(US20240010658, Example 3)
Affinity DataIC50:  5nMAssay Description:First, 1-arachidonoyl glycerol (Cayman Chemical) as a substrate was prepared with an assay buffer containing 50 mM tris-HCl (pH 7.4), 100 mM NaCl, an...More data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand Info
In DepthDetails US Patent
TargetMonoacylglycerol lipase ABHD6(Mus musculus (mouse))
The Scripps Research Institute

LigandPNGBDBM50052782(CHEMBL3318604)
Affinity DataIC50:  10nMAssay Description:Inhibition of FP-rhodamine probe binding to ABHD6 in mouse brain membrane proteome preincubated for 1 hr followed by FP-rhodamine addition and measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoacylglycerol lipase ABHD6(Mus musculus (mouse))
The Scripps Research Institute

LigandPNGBDBM50052781(CHEMBL3318603)
Affinity DataIC50:  10nMAssay Description:Inhibition of FP-rhodamine probe binding to ABHD6 in mouse brain membrane proteome preincubated for 1 hr followed by FP-rhodamine addition and measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoacylglycerol lipase ABHD6(Mus musculus (mouse))
The Scripps Research Institute

LigandPNGBDBM50052783(CHEMBL3318605)
Affinity DataIC50: <10nMAssay Description:Inhibition of FP-rhodamine probe binding to ABHD6 in mouse brain membrane proteome preincubated for 1 hr followed by FP-rhodamine addition and measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoacylglycerol lipase ABHD6(Mus musculus (mouse))
The Scripps Research Institute

LigandPNGBDBM50052767(CHEMBL3318612)
Affinity DataIC50:  10nMAssay Description:Inhibition of FP-rhodamine probe binding to ABHD6 in mouse brain membrane proteome preincubated for 1 hr followed by FP-rhodamine addition and measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoacylglycerol lipase ABHD6(Mus musculus (mouse))
The Scripps Research Institute

LigandPNGBDBM50052768(CHEMBL3318613)
Affinity DataIC50: <10nMAssay Description:Inhibition of FP-rhodamine probe binding to ABHD6 in mouse brain membrane proteome preincubated for 1 hr followed by FP-rhodamine addition and measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoacylglycerol lipase ABHD6(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM24567((2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human ABHD6 expressed in HEK293 cells at 1 uM pre-incubated for 10 mins before 2-AG substrate addition followed by rapid 40 fold compou...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoacylglycerol lipase ABHD6(Mus musculus (mouse))
The Scripps Research Institute

LigandPNGBDBM50010336(CHEMBL3263579)
Affinity DataIC50:  14nMAssay Description:Inhibition of recombinant mouse ABHD6 expressed in HEK293T using 2-arachidonoylglycerol preincubated for 30 mins followed by substrate addition measu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoacylglycerol lipase ABHD6(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM24567((2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-...)
Affinity DataIC50:  14nMAssay Description:Inhibition of human FAAH expressed in COS7 cell membranes pre-incubated for 10 mins before [3H]-AEA substrate addition by liquid scintillation counti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoacylglycerol lipase ABHD6(Mus musculus (mouse))
The Scripps Research Institute

LigandPNGBDBM50010335(CHEMBL3263577)
Affinity DataIC50:  15nMAssay Description:Inhibition of recombinant mouse ABHD6 expressed in HEK293T using 2-arachidonoylglycerol preincubated for 30 mins followed by substrate addition measu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoacylglycerol lipase ABHD6(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM24567((2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human ABHD6 expressed in HEK293 cells at 1 uM pre-incubated for 10 mins before 2-AG substrate addition followed by rapid 40 fold compou...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoacylglycerol lipase ABHD6(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50211260(CHEMBL3964338)
Affinity DataIC50:  20nMAssay Description:Inhibition of human ABHD6 using 2-AG as natural substrate by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoacylglycerol lipase ABHD6(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50211269(CHEMBL3970032)
Affinity DataIC50:  25nMAssay Description:Inhibition of human ABHD6 using 2-AG as natural substrate by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoacylglycerol lipase ABHD6(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM24567((2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-...)
Affinity DataIC50:  37nMAssay Description:Inhibition of human ABHD6 expressed in HEK293 cells at 1 uM pre-incubated for 10 mins before 2-AG substrate addition followed by rapid 40 fold compou...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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