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Found 1131 Enz. Inhib. hit(s) with Target = 'Voltage-dependent N-type calcium channel subunit alpha-1B'
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM247254(US9447029, 1-7)
Affinity DataKi:  100nMAssay Description:Cells and methods: Functional inhibition of the sodium currents is studied using whole cell patch clamp methods (Hamill O. P., Marty A., Neher E., Sa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM247253(US9447029, 1-6)
Affinity DataKi:  100nMAssay Description:Cells and methods: Functional inhibition of the sodium currents is studied using whole cell patch clamp methods (Hamill O. P., Marty A., Neher E., Sa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM247250(US9447029, 1-1)
Affinity DataKi:  100nMAssay Description:Cells and methods: Functional inhibition of the sodium currents is studied using whole cell patch clamp methods (Hamill O. P., Marty A., Neher E., Sa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM247257(US9447029, 1-18)
Affinity DataKi:  200nMAssay Description:Cells and methods: Functional inhibition of the sodium currents is studied using whole cell patch clamp methods (Hamill O. P., Marty A., Neher E., Sa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM247256(US9447029, 1-15)
Affinity DataKi:  200nMAssay Description:Cells and methods: Functional inhibition of the sodium currents is studied using whole cell patch clamp methods (Hamill O. P., Marty A., Neher E., Sa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM247260(US9447029, 1-32)
Affinity DataKi:  300nMAssay Description:Cells and methods: Functional inhibition of the sodium currents is studied using whole cell patch clamp methods (Hamill O. P., Marty A., Neher E., Sa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM247255(US9447029, 1-14)
Affinity DataKi:  500nMAssay Description:Cells and methods: Functional inhibition of the sodium currents is studied using whole cell patch clamp methods (Hamill O. P., Marty A., Neher E., Sa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM247259(US9447029, 1-29)
Affinity DataKi:  700nMAssay Description:Cells and methods: Functional inhibition of the sodium currents is studied using whole cell patch clamp methods (Hamill O. P., Marty A., Neher E., Sa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50022784((R)-N-methyl-3-phenyl-3-(o-tolyloxy)propan-1-amine...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM50171290(5-(4-Bromo-phenyl)-1-(2,4-dichloro-phenyl)-4-ethyl...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM82071(CAS_93413-69-5 | CAS_99300-78-4 | NSC_62923 | VENL...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM247264(US9447029, 4-1)
Affinity DataKi:  1.10E+3nMAssay Description:Cells and methods: Functional inhibition of the sodium currents is studied using whole cell patch clamp methods (Hamill O. P., Marty A., Neher E., Sa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM247263(US9447029, 3-3)
Affinity DataKi:  1.70E+3nMAssay Description:Cells and methods: Functional inhibition of the sodium currents is studied using whole cell patch clamp methods (Hamill O. P., Marty A., Neher E., Sa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM50187673(5-(3,3,6-trimethyl-indan-5-yloxy)-furan-2-carboxyl...)
Affinity DataKi:  5.24E+3nMAssay Description:Binding affinity to verapamil site of N type calcium channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM21280(5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)met...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50049750((S)-3-(azetidin-2-ylmethoxy)pyridine | 3-((S)-1-Az...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50035398((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50133817(4-(3-Chloro-pyridin-2-yl)-piperazine-1-carboxylic ...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM50465794(CHEMBL4288564)
Affinity DataIC50:  1nMAssay Description:Inhibition of Cav2.2 (unknown origin) expressed in HEK293 cells assessed as decrease in KCl depolarization-induced Ca2+ influx measured for 5 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM50465792(CHEMBL4279774)
Affinity DataIC50:  1nMAssay Description:Inhibition of Cav2.2 (unknown origin) expressed in HEK293 cells assessed as decrease in KCl depolarization-induced Ca2+ influx measured for 5 mins by...More data for this Ligand-Target Pair
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM50465788(CHEMBL4292697)
Affinity DataIC50:  1nMAssay Description:Inhibition of Cav2.2 (unknown origin) expressed in HEK293 cells assessed as decrease in KCl depolarization-induced Ca2+ influx measured for 5 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM50465800(CHEMBL4282095)
Affinity DataIC50:  2nMAssay Description:Inhibition of Cav2.2 (unknown origin) expressed in HEK293 cells assessed as decrease in KCl depolarization-induced Ca2+ influx measured for 5 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM50465791(CHEMBL4289288)
Affinity DataIC50:  2nMAssay Description:Inhibition of Cav2.2 (unknown origin) expressed in HEK293 cells assessed as decrease in KCl depolarization-induced Ca2+ influx measured for 5 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM50465796(CHEMBL4290426)
Affinity DataIC50:  2nMAssay Description:Inhibition of Cav2.2 (unknown origin) expressed in HEK293 cells assessed as decrease in KCl depolarization-induced Ca2+ influx measured for 5 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM50465789(CHEMBL4293756)
Affinity DataIC50:  3nMAssay Description:Inhibition of Cav2.2 (unknown origin) expressed in HEK293 cells assessed as decrease in KCl depolarization-induced Ca2+ influx measured for 5 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM611567(US10626144, Compound 25.1)
Affinity DataIC50:  3nMAssay Description:Interaction with N-type calcium channels was assessed with radiolabelled a competitive binding assay, applying the procedure described by Wagner et a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM50465798(CHEMBL4278633)
Affinity DataIC50:  3nMAssay Description:Inhibition of Cav2.2 (unknown origin) expressed in HEK293 cells assessed as decrease in KCl depolarization-induced Ca2+ influx measured for 5 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM611541(US10626144, Compound 22.15)
Affinity DataIC50:  4nMAssay Description:Interaction with N-type calcium channels was assessed with radiolabelled a competitive binding assay, applying the procedure described by Wagner et a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM50465786(CHEMBL4283590)
Affinity DataIC50:  5nMAssay Description:Inhibition of Cav2.2 (unknown origin) expressed in HEK293 cells assessed as decrease in KCl depolarization-induced Ca2+ influx measured for 5 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM50465793(CHEMBL4277584)
Affinity DataIC50:  6nMAssay Description:Inhibition of Cav2.2 (unknown origin) expressed in HEK293 cells assessed as decrease in KCl depolarization-induced Ca2+ influx measured for 5 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM50465802(CHEMBL4294178)
Affinity DataIC50:  6nMAssay Description:Inhibition of Cav2.2 (unknown origin) expressed in HEK293 cells assessed as decrease in KCl depolarization-induced Ca2+ influx measured for 5 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM50465795(CHEMBL4285527)
Affinity DataIC50:  7nMAssay Description:Inhibition of Cav2.2 (unknown origin) expressed in HEK293 cells assessed as decrease in KCl depolarization-induced Ca2+ influx measured for 5 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM50465801(CHEMBL4291986)
Affinity DataIC50:  7nMAssay Description:Inhibition of Cav2.2 (unknown origin) expressed in HEK293 cells assessed as decrease in KCl depolarization-induced Ca2+ influx measured for 5 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM611535(US10626144, Compound Odilomycin C)
Affinity DataIC50:  9nMAssay Description:Interaction with N-type calcium channels was assessed with radiolabelled a competitive binding assay, applying the procedure described by Wagner et a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM50465797(CHEMBL4280661)
Affinity DataIC50:  11nMAssay Description:Inhibition of Cav2.2 (unknown origin) expressed in HEK293 cells assessed as decrease in KCl depolarization-induced Ca2+ influx measured for 5 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM50465790(CHEMBL4284117)
Affinity DataIC50:  12nMAssay Description:Inhibition of Cav2.2 (unknown origin) expressed in HEK293 cells assessed as decrease in KCl depolarization-induced Ca2+ influx measured for 5 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM50465798(CHEMBL4278633)
Affinity DataIC50:  12nMAssay Description:Inhibition of high frequency stimulation-induced Cav2.2 (unknown origin) expressed in HEK293 cells at -80 mV holding membrane potential by automated ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM50465792(CHEMBL4279774)
Affinity DataIC50:  16nMAssay Description:Inhibition of high frequency stimulation-induced Cav2.2 (unknown origin) expressed in HEK293 cells at -80 mV holding membrane potential by automated ...More data for this Ligand-Target Pair
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM50399552(CHEMBL1651027)
Affinity DataIC50:  20nMAssay Description:Inhibition of Cav2.2 expressed HEK293 cells assessed as inhibition of calcium flux by FLIPR assay in presence of 4 mM of potassiumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM50465799(CHEMBL4285877)
Affinity DataIC50:  20nMAssay Description:Inhibition of Cav2.2 (unknown origin) expressed in HEK293 cells assessed as decrease in KCl depolarization-induced Ca2+ influx measured for 5 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM50465803(CHEMBL4292404)
Affinity DataIC50:  22nMAssay Description:Inhibition of Cav2.2 (unknown origin) expressed in HEK293 cells assessed as decrease in KCl depolarization-induced Ca2+ influx measured for 5 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM50465792(CHEMBL4279774)
Affinity DataIC50:  24nMAssay Description:Inhibition of low frequency stimulation-induced Cav2.2 (unknown origin) expressed in HEK293 cells at -80 mV holding membrane potential by automated p...More data for this Ligand-Target Pair
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM611534(US10626144, Compound Odilomycin A)
Affinity DataIC50:  25nMAssay Description:Interaction with N-type calcium channels was assessed with radiolabelled a competitive binding assay, applying the procedure described by Wagner et a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM50465793(CHEMBL4277584)
Affinity DataIC50:  28nMAssay Description:Inhibition of high frequency stimulation-induced Cav2.2 (unknown origin) expressed in HEK293 cells at -80 mV holding membrane potential by automated ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM50465800(CHEMBL4282095)
Affinity DataIC50:  29nMAssay Description:Inhibition of high frequency stimulation-induced Cav2.2 (unknown origin) expressed in HEK293 cells at -80 mV holding membrane potential by automated ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM50465787(CHEMBL4292985)
Affinity DataIC50:  30nMAssay Description:Inhibition of Cav2.2 (unknown origin) expressed in HEK293 cells assessed as decrease in KCl depolarization-induced Ca2+ influx measured for 5 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM611575(US10626144, Compound 224.1)
Affinity DataIC50: <30nMAssay Description:Interaction with N-type calcium channels was assessed with radiolabelled a competitive binding assay, applying the procedure described by Wagner et a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM611573(US10626144, Compound 212.1)
Affinity DataIC50: <30nMAssay Description:Interaction with N-type calcium channels was assessed with radiolabelled a competitive binding assay, applying the procedure described by Wagner et a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM611571(US10626144, Compound 28.1)
Affinity DataIC50: <30nMAssay Description:Interaction with N-type calcium channels was assessed with radiolabelled a competitive binding assay, applying the procedure described by Wagner et a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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