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Found 11 Enz. Inhib. hit(s) with Target = 'Caspase-10'
TargetCaspase-10(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50160974(CHEMBL366927 | [3-(2-{5-tert-Butyl-3-[(4-methyl-fu...)
Affinity DataIC50:  18nMAssay Description:Inhibitory concentration against caspase-10 in neuronal precursor (NT2) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-10(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50160957(CHEMBL179503 | [3-(2-{5-tert-Butyl-3-[(4-methyl-fu...)
Affinity DataIC50:  30nMAssay Description:Inhibitory concentration against casp-10 in neuronal precursor (NT2) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-10(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50426562(CHEMBL2324339)
Affinity DataIC50:  130nMAssay Description:Inhibition of caspase-10 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-10(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50426563(CHEMBL2323967)
Affinity DataIC50:  420nMAssay Description:Inhibition of caspase-10 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-10(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50426566(CHEMBL2324341)
Affinity DataIC50:  590nMAssay Description:Inhibition of caspase-10 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-10(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM160849(US9045524, 123)
Affinity DataIC50:  2.00E+3nMAssay Description:The inhibition of the activity of Caspase-1 to -10 by four different compounds (#53, #111, #123 & Z-DEVD-FMK used as a prodrug: z-D(OMe)E(OMe)VD(OMe)...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-10(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50426564(CHEMBL2323966)
Affinity DataIC50:  2.67E+3nMAssay Description:Inhibition of caspase-10 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-10(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50426565(CHEMBL2324340)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibition of caspase-10 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-10(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM160841(US9045524, 111)
Affinity DataIC50: >3.33E+3nMAssay Description:The inhibition of the activity of Caspase-1 to -10 by four different compounds (#53, #111, #123 & Z-DEVD-FMK used as a prodrug: z-D(OMe)E(OMe)VD(OMe)...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-10(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM160786(US10167313, Compound 53 | US9045524, 53)
Affinity DataIC50: >3.33E+3nMAssay Description:The inhibition of the activity of Caspase-1 to -10 by four different compounds (#53, #111, #123 & Z-DEVD-FMK used as a prodrug: z-D(OMe)E(OMe)VD(OMe)...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-10(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50302107(CHEMBL567893 | Grassystatin A)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of caspase 10 after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed