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Found 143 Enz. Inhib. hit(s) with Target = 'Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'
LigandPNGBDBM50300972(7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)-3-(py...)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50300964(CHEMBL584270 | rac-7-(6-methoxypyridin-3-yl)-1-(2-...)
Affinity DataIC50:  8.60nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Bos taurus (Bovine))
Xuanzhu Pharma

US Patent
LigandPNGBDBM235735(US9359371, 3)
Affinity DataIC50:  8.89nMpH: 7.5Assay Description:Method: The test compound or solvent was incubated at 25° C. for 15 min with enzyme solution (0.2 μg/mL) in Tris-HCl buffer of pH 7.5. 100 μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM50300962(3-(2-ethoxyethylamino)-7-(6-methoxypyridin-3-yl)-1...)
Affinity DataIC50:  9.30nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50300953(3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxyp...)
Affinity DataIC50:  9.80nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50300970(7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)-3-(py...)
Affinity DataIC50:  11nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50296256(7-(6-methoxypyridin-3-yl)-3-(2-morpholinoethylamin...)
Affinity DataIC50:  11nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50300987(3-(3-hydroxypropylamino)-7-(6-methoxypyridin-3-yl)...)
Affinity DataIC50:  14nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50300952(3-(trans-4-hydroxycyclohexylamino)-7-(6-methoxypyr...)
Affinity DataIC50:  15nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50300991((R)-3-(2-hydroxypropylamino)-7-(6-methoxypyridin-3...)
Affinity DataIC50:  15nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50300983(7-(6-methoxypyridin-3-yl)-3-(2-(4-methylpiperazin-...)
Affinity DataIC50:  15nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50300976(2-(7-(6-methoxypyridin-3-yl)-2-oxo-1-(2-propoxyeth...)
Affinity DataIC50:  15nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50300989((S)-3-(2-hydroxypropylamino)-7-(6-methoxypyridin-3...)
Affinity DataIC50:  15nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50300980(7-(6-methoxypyridin-3-yl)-3-(2-morpholino-2-oxoeth...)
Affinity DataIC50:  16nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50300950((S)-3-(1-hydroxypropan-2-ylamino)-7-(6-methoxypyri...)
Affinity DataIC50:  18nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50300948((R)-3-(1-hydroxypropan-2-ylamino)-7-(6-methoxypyri...)
Affinity DataIC50:  18nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50300951((R)-3-(1-hydroxybutan-2-ylamino)-7-(6-methoxypyrid...)
Affinity DataIC50:  23nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50300971(7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)-3-(py...)
Affinity DataIC50:  24nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50300978(3-(2-(4-hydroxypiperidin-1-yl)-2-oxoethylamino)-7-...)
Affinity DataIC50:  25nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50300960(3-(2-hydroxyethylamino)-7-(6-methoxypyridin-3-yl)-...)
Affinity DataIC50:  26nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM480487(US10626113, Compound D | US10899756, Compound D)
Affinity DataIC50:  30nMAssay Description:Materials and Methods: PDE5 inhibition was assayed at BPS Bioscience (San Diego, Calif.) using BPS PDE assay kits (BPS Catalog number 60300, enzyme l...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM480487(US10626113, Compound D | US10899756, Compound D)
Affinity DataIC50:  30nMAssay Description:A series of dilutions of the test compounds were prepared with 10% DMSO in assay buffer and 5 μl of the dilution was added to a 50 μl react...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM50241831(CHEMBL4062273 | US10626113, Compound M | US1089975...)
Affinity DataIC50:  30.1nMAssay Description:Materials and Methods: PDE5 inhibition was assayed at BPS Bioscience (San Diego, Calif.) using BPS PDE assay kits (BPS Catalog number 60300, enzyme l...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM50241831(CHEMBL4062273 | US10626113, Compound M | US1089975...)
Affinity DataIC50:  30.1nMAssay Description:A series of dilutions of the test compounds were prepared with 10% DMSO in assay buffer and 5 μl of the dilution was added to a 50 μl react...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM50300963(7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)-3-((t...)
Affinity DataIC50:  31nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50300969(7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)-3-(py...)
Affinity DataIC50:  35nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50300977(7-(6-methoxypyridin-3-yl)-3-(2-oxo-2-(pyrrolidin-1...)
Affinity DataIC50:  40nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50300966(2-(7-(6-methoxypyridin-3-yl)-2-oxo-1-(2-propoxyeth...)
Affinity DataIC50:  46nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50300990((R)-3-(2-hydroxypropylamino)-7-(6-methoxypyridin-3...)
Affinity DataIC50:  50nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50300988((S)-3-(2-hydroxypropylamino)-7-(6-methoxypyridin-3...)
Affinity DataIC50:  52nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50300985(3-(2-(4-ethylpiperazin-1-yl)-2-oxoethylamino)-7-(6...)
Affinity DataIC50:  56nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50300961(3-(2-ethoxyethylamino)-7-(6-methoxypyridin-3-yl)-1...)
Affinity DataIC50:  57nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50238860(CHEMBL4099219)
Affinity DataIC50:  58nMAssay Description:Inhibition of PDE6A (484 to 817 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using [3H]cGMP or [3H]cAMP as substrate after 15 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Bos taurus (Bovine))
Xuanzhu Pharma

US Patent
LigandPNGBDBM235755(US9359371, 38)
Affinity DataIC50:  58nMpH: 7.5Assay Description:Method: The test compound or solvent was incubated at 25° C. for 15 min with enzyme solution (0.2 μg/mL) in Tris-HCl buffer of pH 7.5. 100 μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Bos taurus (Bovine))
Xuanzhu Pharma

US Patent
LigandPNGBDBM235742(US9359371, 11)
Affinity DataIC50:  61nMpH: 7.5Assay Description:Method: The test compound or solvent was incubated at 25° C. for 15 min with enzyme solution (0.2 μg/mL) in Tris-HCl buffer of pH 7.5. 100 μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM50296257(7-(6-methoxypyridin-3-yl)-3-(2-morpholinoethylamin...)
Affinity DataIC50:  62nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50300947((R)-3-(1-hydroxypropan-2-ylamino)-7-(6-methoxypyri...)
Affinity DataIC50:  63nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50300949((S)-3-(1-hydroxypropan-2-ylamino)-7-(6-methoxypyri...)
Affinity DataIC50:  68nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50300982(7-(6-methoxypyridin-3-yl)-3-(2-(4-methylpiperazin-...)
Affinity DataIC50:  80nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50300968(2-(7-(6-methoxypyridin-3-yl)-2-oxo-1-(2-propoxyeth...)
Affinity DataIC50:  87nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50300974(2-(7-(6-methoxypyridin-3-yl)-2-oxo-1-(2-propoxyeth...)
Affinity DataIC50:  87nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50300984(3-(2-(4-ethylpiperazin-1-yl)-2-oxoethylamino)-7-(6...)
Affinity DataIC50:  99nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50300981(7-(6-methoxypyridin-3-yl)-3-(2-oxo-2-(piperazin-1-...)
Affinity DataIC50:  100nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50241837(CHEMBL4102913 | US10626113, Compound G | US1089975...)
Affinity DataIC50: >100nMAssay Description:A series of dilutions of the test compounds were prepared with 10% DMSO in assay buffer and 5 μl of the dilution was added to a 50 μl react...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM50241837(CHEMBL4102913 | US10626113, Compound G | US1089975...)
Affinity DataIC50: >100nMAssay Description:Materials and Methods: PDE5 inhibition was assayed at BPS Bioscience (San Diego, Calif.) using BPS PDE assay kits (BPS Catalog number 60300, enzyme l...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM50300979(7-(6-methoxypyridin-3-yl)-3-(2-morpholino-2-oxoeth...)
Affinity DataIC50:  114nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50300959(3-(2-hydroxyethylamino)-7-(6-methoxypyridin-3-yl)-...)
Affinity DataIC50:  114nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50300975(2-(7-(6-methoxypyridin-3-yl)-2-oxo-1-(2-propoxyeth...)
Affinity DataIC50:  115nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50300986(3-(3-hydroxypropylamino)-7-(6-methoxypyridin-3-yl)...)
Affinity DataIC50:  124nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Bos taurus (Bovine))
Xuanzhu Pharma

US Patent
LigandPNGBDBM14390(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)
Affinity DataIC50:  140nMAssay Description:Inhibition of bovine retina PDE6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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