KEGG   Homo sapiens (human): 5894
Entry
5894              CDS       T01001                                 
Symbol
RAF1, CMD1NN, CRAF, NS5, Raf-1, c-Raf
Name
(RefSeq) Raf-1 proto-oncogene, serine/threonine kinase
  KO
K04366  RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa01522  Endocrine resistance
hsa04010  MAPK signaling pathway
hsa04012  ErbB signaling pathway
hsa04014  Ras signaling pathway
hsa04015  Rap1 signaling pathway
hsa04022  cGMP-PKG signaling pathway
hsa04024  cAMP signaling pathway
hsa04062  Chemokine signaling pathway
hsa04068  FoxO signaling pathway
hsa04071  Sphingolipid signaling pathway
hsa04072  Phospholipase D signaling pathway
hsa04140  Autophagy - animal
hsa04150  mTOR signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04210  Apoptosis
hsa04218  Cellular senescence
hsa04270  Vascular smooth muscle contraction
hsa04360  Axon guidance
hsa04370  VEGF signaling pathway
hsa04371  Apelin signaling pathway
hsa04510  Focal adhesion
hsa04540  Gap junction
hsa04550  Signaling pathways regulating pluripotency of stem cells
hsa04613  Neutrophil extracellular trap formation
hsa04625  C-type lectin receptor signaling pathway
hsa04630  JAK-STAT signaling pathway
hsa04650  Natural killer cell mediated cytotoxicity
hsa04660  T cell receptor signaling pathway
hsa04662  B cell receptor signaling pathway
hsa04664  Fc epsilon RI signaling pathway
hsa04666  Fc gamma R-mediated phagocytosis
hsa04720  Long-term potentiation
hsa04722  Neurotrophin signaling pathway
hsa04726  Serotonergic synapse
hsa04730  Long-term depression
hsa04810  Regulation of actin cytoskeleton
hsa04910  Insulin signaling pathway
hsa04912  GnRH signaling pathway
hsa04914  Progesterone-mediated oocyte maturation
hsa04915  Estrogen signaling pathway
hsa04916  Melanogenesis
hsa04917  Prolactin signaling pathway
hsa04919  Thyroid hormone signaling pathway
hsa04921  Oxytocin signaling pathway
hsa04926  Relaxin signaling pathway
hsa04928  Parathyroid hormone synthesis, secretion and action
hsa04929  GnRH secretion
hsa04935  Growth hormone synthesis, secretion and action
hsa05010  Alzheimer disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05034  Alcoholism
hsa05132  Salmonella infection
hsa05152  Tuberculosis
hsa05160  Hepatitis C
hsa05161  Hepatitis B
hsa05163  Human cytomegalovirus infection
hsa05164  Influenza A
hsa05165  Human papillomavirus infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05200  Pathways in cancer
hsa05205  Proteoglycans in cancer
hsa05206  MicroRNAs in cancer
hsa05207  Chemical carcinogenesis - receptor activation
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05210  Colorectal cancer
hsa05211  Renal cell carcinoma
hsa05212  Pancreatic cancer
hsa05213  Endometrial cancer
hsa05214  Glioma
hsa05215  Prostate cancer
hsa05218  Melanoma
hsa05219  Bladder cancer
hsa05220  Chronic myeloid leukemia
hsa05221  Acute myeloid leukemia
hsa05223  Non-small cell lung cancer
hsa05224  Breast cancer
hsa05225  Hepatocellular carcinoma
hsa05226  Gastric cancer
hsa05230  Central carbon metabolism in cancer
hsa05231  Choline metabolism in cancer
hsa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Network
nt06162  Hepatitis B virus (HBV)
nt06163  Hepatitis C virus (HCV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06166  Human papillomavirus (HPV)
nt06167  Human cytomegalovirus (HCMV)
nt06170  Influenza A virus (IAV)
nt06181  Salmonella
nt06210  ERK signaling (cancer)
nt06220  Calcium signaling (cancer)
nt06224  CXCR signaling (cancer)
nt06230  Cell cycle (cancer)
nt06260  Colorectal cancer
nt06261  Gastric cancer
nt06262  Pancreatic cancer
nt06263  Hepatocellular carcinoma
nt06264  Renal cell carcinoma
nt06265  Bladder cancer
nt06266  Non-small cell lung cancer
nt06268  Melanoma
nt06270  Breast cancer
nt06271  Endometrial cancer
nt06273  Glioma
nt06274  Thyroid cancer
nt06275  Acute myeloid leukemia
nt06276  Chronic myeloid leukemia
nt06323  KISS1-GnRH-LH/FSH-E2 signaling
nt06324  GHRH-GH-IGF signaling
nt06460  Alzheimer disease
nt06466  Pathways of neurodegeneration
nt06526  MAPK signaling
  Element
N00001  EGF-EGFR-RAS-ERK signaling pathway
N00002  BCR-ABL fusion kinase to RAS-ERK signaling pathway
N00003  Mutation-activated KIT to RAS-ERK signaling pathway
N00004  Duplication or mutation-activated FLT3 to RAS-ERK signaling pathway
N00005  Mutation-activated MET to RAS-ERK signaling pathway
N00006  Amplified EGFR to RAS-ERK signaling pathway
N00007  EML4-ALK fusion kinase to RAS-ERK signaling pathway
N00008  RET fusion kinase to RAS-ERK signaling pathway
N00009  TRK fusion kinase to RAS-ERK signaling pathway
N00011  Mutation-activated FGFR3 to RAS-ERK signaling pathway
N00012  Mutation-activated KRAS/NRAS to ERK signaling pathway
N00014  Mutation-activated EGFR to RAS-ERK signaling pathway
N00015  PDGF-PDGFR-RAS-ERK signaling pathway
N00016  PDGF-overexpression to RAS-ERK signaling pathway
N00018  Amplified PDGFR to RAS-ERK signaling pathway
N00019  FGF-FGFR-RAS-ERK signaling pathway
N00020  Amplified FGFR to RAS-ERK signaling pathway
N00021  EGF-ERBB2-RAS-ERK signaling pathway
N00022  ERBB2-overexpression to RAS-ERK signaling pathway
N00023  EGF-EGFR-PLCG-ERK signaling pathway
N00024  Mutation-activated EGFR to PLCG-ERK signaling pathway
N00025  EML4-ALK fusion kinase to PLCG-ERK signaling pathway
N00041  EGFR-overexpression to RAS-ERK signaling pathway
N00077  HRAS-overexpression to ERK signaling pathway
N00078  Mutation-activated HRAS to ERK signaling pathway
N00152  CXCR-GNB/G-ERK signaling pathway
N00215  KITLG-KIT-RAS-ERK signaling pathway
N00216  HGF-MET-RAS-ERK signaling pathway
N00217  FLT3LG-FLT3-RAS-ERK signaling pathway
N00229  TGFA-EGFR-RAS-ERK signaling pathway
N00230  TGFA-overexpression to RAS-ERK signaling pathway
N00233  IGF-IGF1R-RAS-ERK signaling pathway
N00235  IGF2-overexpression to RAS-ERK signaling pathway
N00237  IGF1R-overexpression to RAS-ERK signaling pathway
N00246  HGF-overexpression to RAS-ERK signaling pathway
N00248  MET-overexpression to RAS-ERK signaling pathway
N00252  Amplified ERBB2 to RAS-ERK signaling pathway
N00259  Amplified MET to RAS-ERK signaling pathway
N00276  EGF-overexpression to RAS-ERK signaling pathway
N00277  EREG-EGFR-RAS-ERK signaling pathway
N00278  EREG-overexpression to RAS-ERK signaling pathway
N00279  AREG-EGFR-RAS-ERK signaling pathway
N00280  AREG-overexpression to RAS-ERK signaling pathway
N00367  HPV E5 to EGFR-RAS-ERK signaling pathway
N00386  HCMV gB to PDGFR-RAS-ERK signaling pathway
N00513  Mutation-activated EGFR to RAS-ERK signaling pathway
N00518  HCV Core to ERK signaling pathway
N00538  Ca2+-PYK2-RAS-ERK signaling pathway
N00540  HBV HBx to RAS-ERK signaling pathway
N00546  CXCL12-CXCR4-PKC-ERK signaling pathaway
N00744  IAV HA to ERK signaling pathway
N00873  GnRH-GnRHR-PLCB-PKC signaling pathway
N00994  AGE-RAGE signaling pathway
N00996  Mutation-caused aberrant Abeta to AGE-RAGE signaling pathway
N01062  Mutation-activated MET to RAS-ERK signaling pathway
N01064  Mutation-activated RET to RAS-ERK signaling pathway
N01119  RAC/CDC42-PAK-ERK signaling pathway
N01336  CHRNA7-E2F signaling pathway
N01337  NNK/NNN to CHRNA7-E2F signaling pathway
N01343  ACH-CHRN-RAS-ERK signaling pathway
N01344  NNK/NNN to RAS-ERK signaling pathway
N01351  E2-ER-RAS-ERK signaling pathway
N01352  BPA to RAS-ERK signaling pathway
N01353  E2 to RAS-ERK signaling pathway
N01354  BPA to RAS-ERK signaling pathway
N01360  P4-PR-RAS-ERK signaling pathway
N01361  P4/MPA to PR-RAS-ERK signaling pathway
N01408  Metals to RAS-ERK signaling pathway
N01592  GF-RTK-RAS-ERK signaling pathway
N01598  Regulation of GF-RTK-RAS-ERK signaling, MRAS-SHOC2-PP1 holophosphatase
Disease
H00294  Dilated cardiomyopathy
H00523  Noonan syndrome and related disorders
H01738  Noonan syndrome
H01984  Leopard syndrome
Drug target
Avutometinib (DG03255): D12515 D12534
Naporafenib: D12831
Regorafenib (DG00720): D10137<JP/US> D10138
Sorafenib (DG00713): D06272<JP/US> D08524
Tovorafenib: D12291
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    5894 (RAF1)
   04012 ErbB signaling pathway
    5894 (RAF1)
   04014 Ras signaling pathway
    5894 (RAF1)
   04015 Rap1 signaling pathway
    5894 (RAF1)
   04370 VEGF signaling pathway
    5894 (RAF1)
   04371 Apelin signaling pathway
    5894 (RAF1)
   04630 JAK-STAT signaling pathway
    5894 (RAF1)
   04068 FoxO signaling pathway
    5894 (RAF1)
   04072 Phospholipase D signaling pathway
    5894 (RAF1)
   04071 Sphingolipid signaling pathway
    5894 (RAF1)
   04024 cAMP signaling pathway
    5894 (RAF1)
   04022 cGMP-PKG signaling pathway
    5894 (RAF1)
   04151 PI3K-Akt signaling pathway
    5894 (RAF1)
   04150 mTOR signaling pathway
    5894 (RAF1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    5894 (RAF1)
  09143 Cell growth and death
   04210 Apoptosis
    5894 (RAF1)
   04218 Cellular senescence
    5894 (RAF1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    5894 (RAF1)
   04540 Gap junction
    5894 (RAF1)
   04550 Signaling pathways regulating pluripotency of stem cells
    5894 (RAF1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    5894 (RAF1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    5894 (RAF1)
   04625 C-type lectin receptor signaling pathway
    5894 (RAF1)
   04650 Natural killer cell mediated cytotoxicity
    5894 (RAF1)
   04660 T cell receptor signaling pathway
    5894 (RAF1)
   04662 B cell receptor signaling pathway
    5894 (RAF1)
   04664 Fc epsilon RI signaling pathway
    5894 (RAF1)
   04666 Fc gamma R-mediated phagocytosis
    5894 (RAF1)
   04062 Chemokine signaling pathway
    5894 (RAF1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    5894 (RAF1)
   04929 GnRH secretion
    5894 (RAF1)
   04912 GnRH signaling pathway
    5894 (RAF1)
   04915 Estrogen signaling pathway
    5894 (RAF1)
   04914 Progesterone-mediated oocyte maturation
    5894 (RAF1)
   04917 Prolactin signaling pathway
    5894 (RAF1)
   04921 Oxytocin signaling pathway
    5894 (RAF1)
   04926 Relaxin signaling pathway
    5894 (RAF1)
   04935 Growth hormone synthesis, secretion and action
    5894 (RAF1)
   04919 Thyroid hormone signaling pathway
    5894 (RAF1)
   04928 Parathyroid hormone synthesis, secretion and action
    5894 (RAF1)
   04916 Melanogenesis
    5894 (RAF1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    5894 (RAF1)
  09156 Nervous system
   04726 Serotonergic synapse
    5894 (RAF1)
   04720 Long-term potentiation
    5894 (RAF1)
   04730 Long-term depression
    5894 (RAF1)
   04722 Neurotrophin signaling pathway
    5894 (RAF1)
  09158 Development and regeneration
   04360 Axon guidance
    5894 (RAF1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    5894 (RAF1)
   05206 MicroRNAs in cancer
    5894 (RAF1)
   05205 Proteoglycans in cancer
    5894 (RAF1)
   05207 Chemical carcinogenesis - receptor activation
    5894 (RAF1)
   05208 Chemical carcinogenesis - reactive oxygen species
    5894 (RAF1)
   05230 Central carbon metabolism in cancer
    5894 (RAF1)
   05231 Choline metabolism in cancer
    5894 (RAF1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    5894 (RAF1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    5894 (RAF1)
   05212 Pancreatic cancer
    5894 (RAF1)
   05225 Hepatocellular carcinoma
    5894 (RAF1)
   05226 Gastric cancer
    5894 (RAF1)
   05214 Glioma
    5894 (RAF1)
   05221 Acute myeloid leukemia
    5894 (RAF1)
   05220 Chronic myeloid leukemia
    5894 (RAF1)
   05218 Melanoma
    5894 (RAF1)
   05211 Renal cell carcinoma
    5894 (RAF1)
   05219 Bladder cancer
    5894 (RAF1)
   05215 Prostate cancer
    5894 (RAF1)
   05213 Endometrial cancer
    5894 (RAF1)
   05224 Breast cancer
    5894 (RAF1)
   05223 Non-small cell lung cancer
    5894 (RAF1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    5894 (RAF1)
   05161 Hepatitis B
    5894 (RAF1)
   05160 Hepatitis C
    5894 (RAF1)
   05164 Influenza A
    5894 (RAF1)
   05163 Human cytomegalovirus infection
    5894 (RAF1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    5894 (RAF1)
   05165 Human papillomavirus infection
    5894 (RAF1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    5894 (RAF1)
   05152 Tuberculosis
    5894 (RAF1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    5894 (RAF1)
   05022 Pathways of neurodegeneration - multiple diseases
    5894 (RAF1)
  09165 Substance dependence
   05034 Alcoholism
    5894 (RAF1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    5894 (RAF1)
   01522 Endocrine resistance
    5894 (RAF1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    5894 (RAF1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     5894 (RAF1)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   5894 (RAF1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr RBD C1_1 Kinase-like ABC1 zf-RING-like Pkinase_fungal C1_2
Other DBs
NCBI-GeneID: 5894
NCBI-ProteinID: NP_002871
OMIM: 164760
HGNC: 9829
Ensembl: ENSG00000132155
UniProt: P04049 L7RRS6
Structure
Position
3:complement(12583601..12664117)
AA seq 648 aa
MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
SPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
NT seq 1947 nt   +upstreamnt  +downstreamnt
atggagcacatacagggagcttggaagacgatcagcaatggttttggattcaaagatgcc
gtgtttgatggctccagctgcatctctcctacaatagttcagcagtttggctatcagcgc
cgggcatcagatgatggcaaactcacagatccttctaagacaagcaacactatccgtgtt
ttcttgccgaacaagcaaagaacagtggtcaatgtgcgaaatggaatgagcttgcatgac
tgccttatgaaagcactcaaggtgaggggcctgcaaccagagtgctgtgcagtgttcaga
cttctccacgaacacaaaggtaaaaaagcacgcttagattggaatactgatgctgcgtct
ttgattggagaagaacttcaagtagatttcctggatcatgttcccctcacaacacacaac
tttgctcggaagacgttcctgaagcttgccttctgtgacatctgtcagaaattcctgctc
aatggatttcgatgtcagacttgtggctacaaatttcatgagcactgtagcaccaaagta
cctactatgtgtgtggactggagtaacatcagacaactcttattgtttccaaattccact
attggtgatagtggagtcccagcactaccttctttgactatgcgtcgtatgcgagagtct
gtttccaggatgcctgttagttctcagcacagatattctacacctcacgccttcaccttt
aacacctccagtccctcatctgaaggttccctctcccagaggcagaggtcgacatccaca
cctaatgtccacatggtcagcaccaccctgcctgtggacagcaggatgattgaggatgca
attcgaagtcacagcgaatcagcctcaccttcagccctgtccagtagccccaacaatctg
agcccaacaggctggtcacagccgaaaacccccgtgccagcacaaagagagcgggcacca
gtatctgggacccaggagaaaaacaaaattaggcctcgtggacagagagattcaagctat
tattgggaaatagaagccagtgaagtgatgctgtccactcggattgggtcaggctctttt
ggaactgtttataagggtaaatggcacggagatgttgcagtaaagatcctaaaggttgtc
gacccaaccccagagcaattccaggccttcaggaatgaggtggctgttctgcgcaaaaca
cggcatgtgaacattctgcttttcatggggtacatgacaaaggacaacctggcaattgtg
acccagtggtgcgagggcagcagcctctacaaacacctgcatgtccaggagaccaagttt
cagatgttccagctaattgacattgcccggcagacggctcagggaatggactatttgcat
gcaaagaacatcatccatagagacatgaaatccaacaatatatttctccatgaaggctta
acagtgaaaattggagattttggtttggcaacagtaaagtcacgctggagtggttctcag
caggttgaacaacctactggctctgtcctctggatggccccagaggtgatccgaatgcag
gataacaacccattcagtttccagtcggatgtctactcctatggcatcgtattgtatgaa
ctgatgacgggggagcttccttattctcacatcaacaaccgagatcagatcatcttcatg
gtgggccgaggatatgcctccccagatcttagtaagctatataagaactgccccaaagca
atgaagaggctggtagctgactgtgtgaagaaagtaaaggaagagaggcctctttttccc
cagatcctgtcttccattgagctgctccaacactctctaccgaagatcaaccggagcgct
tccgagccatccttgcatcgggcagcccacactgaggatatcaatgcttgcacgctgacc
acgtccccgaggctgcctgtcttctag

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (83)   
   KEGG PATHWAY (83)   
Network (100)   
   KEGG NETWORK (100)   
Disease (8)   
   KEGG DISEASE (4)   
   OMIM (4)   
Drug (8)   
   KEGG DRUG (8)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (18)   
   KEGG ORTHOLOGY (1)   
   RefGene (9)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
Protein sequence (21)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (18)   
DNA sequence (47)   
   RefSeq(nuc) (21)   
   GenBank (13)   
   EMBL (13)   
3D Structure (41)   
   PDB (41)   
Protein domain (9)   
   Pfam (9)   
All databases (340)   

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