KEGG T01001: 3567

Homo sapiens (human): 3567

Entry

3567              CDS       T01001

Symbol

IL5, EDF, IL-5, TRF

Name

(RefSeq) interleukin 5

K05428

interleukin 5

Organism

hsa Homo sapiens (human)

Pathway

hsa04060

Cytokine-cytokine receptor interaction

hsa04630

JAK-STAT signaling pathway

hsa04640

Hematopoietic cell lineage

hsa04657

IL-17 signaling pathway

hsa04658

Th1 and Th2 cell differentiation

hsa04660

T cell receptor signaling pathway

hsa04664

Fc epsilon RI signaling pathway

hsa04672

Intestinal immune network for IgA production

hsa05200

Pathways in cancer

hsa05310

Asthma

hsa05320

Autoimmune thyroid disease

hsa05321

Inflammatory bowel disease

hsa05330

Allograft rejection

Network

nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06162  Hepatitis B virus (HBV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06219  JAK-STAT signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06266  Non-small cell lung cancer
nt06276  Chronic myeloid leukemia
nt06518  JAK-STAT signaling

Element

N00053

Cytokine-Jak-STAT signaling pathway

N01804

IL3 family to Jak-STAT signaling pathway

Drug target

Depemokimab:

D12169

Mepolizumab:

D04923<JP/US>

Reslizumab:

D08985<US>

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    3567 (IL5)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    3567 (IL5)
09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    3567 (IL5)
   04660 T cell receptor signaling pathway
    3567 (IL5)
   04658 Th1 and Th2 cell differentiation
    3567 (IL5)
   04657 IL-17 signaling pathway
    3567 (IL5)
   04664 Fc epsilon RI signaling pathway
    3567 (IL5)
   04672 Intestinal immune network for IgA production
    3567 (IL5)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    3567 (IL5)
  09163 Immune disease
   05310 Asthma
    3567 (IL5)
   05320 Autoimmune thyroid disease
    3567 (IL5)
   05321 Inflammatory bowel disease
    3567 (IL5)
   05330 Allograft rejection
    3567 (IL5)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides [BR:hsa04052]
    3567 (IL5)
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    3567 (IL5)
Cytokines and neuropeptides [BR:hsa04052]
Cytokines
  Interleukins
   3567 (IL5)
Glycosaminoglycan binding proteins [BR:hsa00536]
Heparan sulfate / Heparin
  Cytokines
   3567 (IL5)

SSDB

Motif

Pfam:

IL5 DUF6034

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

Position

5:complement(132541445..132556815)

AA seq 134 aa
MRMLLHLSLLALGAAYVYAIPTEIPTSALVKETLALLSTHRTLLIANETLRIPVPVHKNH
QLCTEEIFQGIGTLESQTVQGGTVERLFKNLSLIKKYIDGQKKKCGEERRRVNQFLDYLQ
EFLGVMNTEWIIES

NT seq 405 nt +upstreamnt +downstreamnt
atgaggatgcttctgcatttgagtttgctagctcttggagctgcctacgtgtatgccatc
cccacagaaattcccacaagtgcattggtgaaagagaccttggcactgctttctactcat
cgaactctgctgatagccaatgagactctgaggattcctgttcctgtacataaaaatcac
caactgtgcactgaagaaatctttcagggaataggcacactggagagtcaaactgtgcaa
gggggtactgtggaaagactattcaaaaacttgtccttaataaagaaatacattgacggc
caaaaaaaaaagtgtggagaagaaagacggagagtaaaccaattcctagactacctgcaa
gagtttcttggtgtaatgaacaccgagtggataatagaaagttga

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