1Z8A: Human Aldose Reductase complexed with novel Sulfonyl-pyridazinone Inhibitor

PDB ID: 1Z8ADownload
MMDB ID: 37916
PDB Deposition Date: 2005/3/30
Updated in MMDB: 2017/11
Experimental Method:
x-ray diffraction
Resolution: 0.95  Å
Source Organism:
Similar Structures:
Biological Unit for 1Z8A: monomeric; determined by author
Molecular Components in 1Z8A
Label Count Molecule
Protein (1 molecule)
1
Aldose Reductase
(Gene symbol: AKR1B1)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
1
NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATENADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
2
1
6-[(5-CHLORO-3-METHYL-1-BENZOFURAN-2-YL)SULFONYL]PYRIDAZIN-3(2H)-ONE6-[(5-CHLORO-3-METHYL-1-BENZOFURAN-2-YL)SULFONYL]PYRIDAZIN-3(2H)-ONE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303