4G2W: Crystal structure of PDE5A in complex with its inhibitor

PDB ID: 4G2WDownload
MMDB ID: 111251
PDB Deposition Date: 2012/7/13
Updated in MMDB: 2023/11
Experimental Method:
x-ray diffraction
Resolution: 2.28  Å
Source Organism:
Similar Structures:
Biological Unit for 4G2W: monomeric; determined by author and by software (PISA)
Molecular Components in 4G2W
Label Count Molecule
Protein (1 molecule)
1
Cgmp-specific 3',5'-cyclic Phosphodiesterase
(Gene symbol: PDE5A)
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
1
5,6-diethyl-2-{5-[(4-methylpiperazin-1-yl)sulfonyl]-2-propoxyphenyl}pyrimidin-4(3H)-one5,6-diethyl-2-{5-[(4-methylpiperazin-1-yl)sulfonyl]-2-propoxyphenyl}pyrimidin-4(3H)-one
2
1
MAGNESIUM IONMAGNESIUM ION
3
1
DI(HYDROXYETHYL)ETHERDI(HYDROXYETHYL)ETHER
4
1
ZINC IONZINC ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303