Abstract
Table 2 summarizes the potential clinical consequences of neurotransmitter receptor blockade by neuroleptics. These pharmacological effects of neuroleptics at receptors in brain and elsewhere in the body are likely responsible for therapeutic and certain adverse effects as well as some drug-drug interactions. Data presented here should allow the physician a rational basis for selecting neuroleptics to minimize these unwanted effects in patients.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Antipsychotic Agents / adverse effects
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Antipsychotic Agents / metabolism*
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Antipsychotic Agents / pharmacology
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Brain / drug effects
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Brain / metabolism*
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Humans
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Receptors, Adrenergic, alpha / drug effects
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Receptors, Adrenergic, alpha / metabolism
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Receptors, Dopamine / drug effects
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Receptors, Dopamine / metabolism
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Receptors, Dopamine D2
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Receptors, Histamine / drug effects
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Receptors, Histamine / metabolism
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Receptors, Muscarinic / drug effects
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Receptors, Muscarinic / metabolism
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Receptors, Neurotransmitter / drug effects
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Receptors, Neurotransmitter / metabolism*
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Receptors, Serotonin / drug effects
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Receptors, Serotonin / metabolism
Substances
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Antipsychotic Agents
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Receptors, Adrenergic, alpha
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Receptors, Dopamine
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Receptors, Dopamine D2
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Receptors, Histamine
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Receptors, Muscarinic
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Receptors, Neurotransmitter
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Receptors, Serotonin