Synthesis of tetrakis(multifluoro-4-pyridyl)porphin derivatives as acetylcholinesterase inhibitors

S C Moon; J H Shin; B H Jeong; H S Kim; B S Yu; J S Lee; B S Lee; S K Namgoong

doi:10.1016/s0960-894x(00)00254-7

Synthesis of tetrakis(multifluoro-4-pyridyl)porphin derivatives as acetylcholinesterase inhibitors

Bioorg Med Chem Lett. 2000 Jul 3;10(13):1435-8. doi: 10.1016/s0960-894x(00)00254-7.

Authors

S C Moon¹, J H Shin, B H Jeong, H S Kim, B S Yu, J S Lee, B S Lee, S K Namgoong

Affiliation

¹ Department of Chemistry, Seoul National University, South Korea.

PMID: 10888326
DOI: 10.1016/s0960-894x(00)00254-7

Abstract

New tetrakis(multifluoro-4-pyridyl)porphin derivatives (2-4) and water soluble porphyrin (5) were synthesized to investigate their interactions with acetylcholinesterase from electric eel. These compounds have been found to be the potent reversible inhibitors of the enzyme with Ki values of microM range. In addition, porphyrin (5) showed broad spectrum of anticancer activities.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology*
Cholinesterase Inhibitors / chemical synthesis*
Cholinesterase Inhibitors / chemistry
Cholinesterase Inhibitors / pharmacology
Drug Design
Drug Screening Assays, Antitumor
HL-60 Cells
Humans
Kinetics
Melanoma, Experimental
Molecular Structure
Porphyrins / chemical synthesis*
Porphyrins / chemistry
Porphyrins / pharmacology*

Substances

Antineoplastic Agents
Cholinesterase Inhibitors
Porphyrins