Abstract
Open D-ring galanthamine analogues were prepared using ring-opening reactions of the quaternarized urethane or oxazolidine functions and were evaluated for their acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition potency.
MeSH terms
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Animals
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Butyrylcholinesterase / metabolism
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Cholinesterase Inhibitors / chemical synthesis*
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Cholinesterase Inhibitors / pharmacology*
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Electric Organ / drug effects
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Electric Organ / enzymology
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Electrophorus
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Galantamine / analogs & derivatives
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Galantamine / chemical synthesis*
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Galantamine / pharmacology*
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Magnetic Resonance Spectroscopy
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Models, Molecular
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Molecular Conformation
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Structure-Activity Relationship
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Substrate Specificity
Substances
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Cholinesterase Inhibitors
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Galantamine
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Butyrylcholinesterase