Abstract
Several bisbenzylisoquinoline alkaloid derivatives showed the inhibitory activity at acetylcholinesterase enzyme (AChE) in micromolar range. It is possible that monomeric moiety of bisbenzylisoquinoline alkaloid might be required for acetylcholinesterase enzyme inhibition. AChE inhibitory activity of related monomeric 1-benzylisoquinolines was examined by using Ellman colorimetric assay with galanthamine as a reference standard.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetylcholinesterase / metabolism*
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Alkaloids / chemical synthesis
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Alkaloids / pharmacology
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Alzheimer Disease / drug therapy
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Animals
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Benzylisoquinolines / chemical synthesis
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Benzylisoquinolines / pharmacology
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Binding Sites
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Cholinesterase Inhibitors / chemical synthesis*
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Cholinesterase Inhibitors / pharmacology
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Colorimetry
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Humans
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Isoquinolines / chemical synthesis*
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Isoquinolines / pharmacology
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Structure-Activity Relationship
Substances
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Alkaloids
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Benzylisoquinolines
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Cholinesterase Inhibitors
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Isoquinolines
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Acetylcholinesterase