Abstract
Cyclization by double reductive amination of L-arabino-hexos-5-ulose with suitably protected D- as well as L-lysine derivatives provided 1-deoxygalactonojirimycin lysine hybrids without any observable epimer formation at C-5. Modifications on the lysine moiety by acylation gave access to lipophilic derivatives which exhibited excellent D-galactosidase inhibitory activities.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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1-Deoxynojirimycin / chemistry*
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Acylation
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Chimera
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / metabolism
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Enzyme Inhibitors / pharmacology
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Galactosidases / antagonists & inhibitors*
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Galactosidases / metabolism
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Kinetics
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Lysine / chemistry*
Substances
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Enzyme Inhibitors
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1-Deoxynojirimycin
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Galactosidases
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Lysine