Abstract
Acetylcholinesterase (AChE) inhibitory activity-guided fractionation of Angelica gigas led to isolation and identification of a new coumarin, peucedanone (12), and isolation of 11 known coumarins. Among them, decursinol (1) represented the highest inhibitory activity toward AChE in vitro. The correlation of the inhibitory activities of the coumarins toward AChE with their chemical structures was studied.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cholinesterase Inhibitors / isolation & purification*
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Cholinesterase Inhibitors / pharmacology*
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Coumarins / isolation & purification*
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Coumarins / pharmacology*
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Korea
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Magnetic Resonance Spectroscopy
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Plant Extracts / chemistry
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Plants, Medicinal / chemistry*
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Spectrophotometry, Infrared
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Spectrophotometry, Ultraviolet
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Structure-Activity Relationship
Substances
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Cholinesterase Inhibitors
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Coumarins
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Plant Extracts