Nonsteroidal antiinflammatory drug hydroxamic acids. Dual inhibitors of both cyclooxygenase and 5-lipoxygenase

J Med Chem. 1990 Aug;33(8):2070-2. doi: 10.1021/jm00170a004.

Authors

D L Flynn¹, T Capiris, W J Cetenko, D T Connor, R D Dyer, C R Kostlan, D E Nies, D J Schrier, J C Sircar

Affiliation

¹ Department of Chemistry, Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, Ann Arbor, Michigan 48105.

PMID: 2115586
DOI: 10.1021/jm00170a004

No abstract available

Publication types

Comparative Study

MeSH terms

Anti-Inflammatory Agents, Non-Steroidal / adverse effects
Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
Arachidonate Lipoxygenases / antagonists & inhibitors*
Cyclooxygenase Inhibitors*
Hydroxamic Acids / adverse effects
Hydroxamic Acids / pharmacology*
Ibuprofen / analogs & derivatives
Ibuprofen / therapeutic use
Indomethacin / analogs & derivatives
Indomethacin / therapeutic use
Lipoxygenase Inhibitors*
Meclofenamic Acid / analogs & derivatives
Meclofenamic Acid / therapeutic use

Substances

Anti-Inflammatory Agents, Non-Steroidal
Cyclooxygenase Inhibitors
Hydroxamic Acids
Lipoxygenase Inhibitors
Meclofenamic Acid
Arachidonate Lipoxygenases
Ibuprofen
Indomethacin