Abstract
An S678P substitution in Fks1p, the major subunit of glucan synthase, was sufficient to confer echinocandin resistance in Aspergillus fumigatus. The equivalent mutation in Candida spp. has been implicated in echinocandin resistance. This work demonstrates that modification of Fks1p is a conserved mechanism for echinocandin resistance in pathogenic fungi.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Amino Acid Sequence
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Amino Acid Substitution*
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Aspergillus fumigatus / drug effects*
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Aspergillus fumigatus / genetics
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Drug Resistance, Fungal / genetics*
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Echinocandins / pharmacology*
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Fungal Proteins / antagonists & inhibitors
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Fungal Proteins / genetics
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Glucosyltransferases / antagonists & inhibitors
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Glucosyltransferases / genetics*
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Molecular Sequence Data
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Proline / genetics
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Sequence Homology, Amino Acid
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Serine / genetics
Substances
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Echinocandins
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Fungal Proteins
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Serine
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Proline
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Glucosyltransferases
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glucan synthase