Abstract
We report the synthesis, anti-inflammatory and antioxidant activities of novel ring substituted 3-phenyl-1-(1,4-di-N-oxide quinoxalin-2-yl)-2-propen-1-one derivatives and of their 4,5-dihydro-(1H)-pyrazole analogues. The tested compounds inhibit the carrageenin-induced rat paw edema (4.5-56.1%) and present important scavenging activities. Compound 2a is the most potent (56.1%) in the in vivo experiment and exhibits promising in vitro inhibition of soybean lipoxygenase (IC(50)<1microM).
Publication types
-
Comparative Study
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis*
-
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
-
Antioxidants / chemical synthesis*
-
Antioxidants / therapeutic use
-
Edema / drug therapy
-
Pyrazoles / chemical synthesis*
-
Pyrazoles / therapeutic use
-
Quinoxalines / chemical synthesis*
-
Quinoxalines / therapeutic use
-
Rats
Substances
-
Anti-Inflammatory Agents, Non-Steroidal
-
Antioxidants
-
Pyrazoles
-
Quinoxalines