Abstract
In order to verify whether azasugar would be a useful scaffold for inhibitory activity against metalloproteinases, we synthesized some azasugar-based compounds. As a result, it is clarified that azasugar moiety could function as successful inhibitor of matrix metalloproteinase-1, -3 and -9 and TACE.
MeSH terms
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ADAM Proteins
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ADAM17 Protein
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Aza Compounds / chemical synthesis*
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Aza Compounds / pharmacology
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Drug Design
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Gluconates / chemistry*
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Kinetics
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Lactones
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Matrix Metalloproteinase Inhibitors*
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Metalloendopeptidases / antagonists & inhibitors*
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Protease Inhibitors / chemical synthesis*
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Protease Inhibitors / pharmacology
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Stereoisomerism
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Structure-Activity Relationship
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Sulfonamides / chemistry
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Zinc / chemistry
Substances
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Aza Compounds
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Gluconates
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Lactones
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Matrix Metalloproteinase Inhibitors
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Protease Inhibitors
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Sulfonamides
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ADAM Proteins
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Metalloendopeptidases
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ADAM17 Protein
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Zinc
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beta-glucono-1,5-lactone