Abstract
Selective monofluorination of the alpha-glycosidase inhibitor and antidiabetic agent Miglitol at position C2 creates an competitive inhibitor of five times higher activity than the parent compound. Its screening against a panel of human cell lines showed a low cytotoxicity therefore making this compound an interesting candidate for further clinical investigations.
MeSH terms
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1-Deoxynojirimycin / analogs & derivatives*
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1-Deoxynojirimycin / chemical synthesis
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1-Deoxynojirimycin / chemistry
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1-Deoxynojirimycin / toxicity
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Cell Line
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Glycoside Hydrolase Inhibitors*
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Halogenation
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Humans
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Hypoglycemic Agents / chemical synthesis
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Hypoglycemic Agents / chemistry*
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Hypoglycemic Agents / toxicity
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alpha-Glucosidases / metabolism
Substances
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Glycoside Hydrolase Inhibitors
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Hypoglycemic Agents
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miglitol
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1-Deoxynojirimycin
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alpha-Glucosidases