2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. SB-206606

SB-206606, a stereoisomer of BRL 37344, is a potentially specific, beta 3-adrenergic receptor (β3-AR) ligand. The affinity of [3H]SB 206606 is 76 times higher for the β3-AR than for the beta 1/beta 2-adrenergic receptors.

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SB-206606 Chemical Structure

SB-206606 Chemical Structure

CAS No. : 116049-78-6

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SB-206606 Related Antibodies

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Description

SB-206606, a stereoisomer of BRL 37344, is a potentially specific, beta 3-adrenergic receptor (β3-AR) ligand. The affinity of [3H]SB 206606 is 76 times higher for the β3-AR than for the beta 1/beta 2-adrenergic receptors[1].

IC50 & Target[1]

Beta-3 adrenergic receptor

 

In Vitro

[3H]SB-206606 binding to membranes from Chinese hamster ovary K1 cells transfected with the rat β3-AR with a Kd value of 58 nM[1].
[3H]SB-206606 binding to brown adipose tissue where beta 1-, beta 2-, and beta 3-adrenergic receptor subtypes are known to coexist with a Kd value of 38 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SB-206606 Related Antibodies
Molecular Weight

363.84

Formula

C19H22ClNO4
CAS No.
SMILES

O=C(COC1=CC=C(C=C1)C[C@@H](C)NC[C@H](O)C2=CC=CC(Cl)=C2)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SB-206606 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SB-206606116049-78-6SB206606SB 206606Adrenergic ReceptorBeta ReceptorBRL 37344Chinese hamster ovary K1 cellsbrown adipose tissueβ1-ARβ2-ARInhibitorinhibitorinhibit

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