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Found 343 with Last Name = 'abraham' and Initial = 'w'
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50205275(CHEMBL426559 | [(3R)-4-(4-chlorobenzyl)-7-fluoro-5...)
Affinity DataKi:  0.570nMAssay Description:Binding affinity to human DP receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane A2 receptor(Homo sapiens (Human))
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50205274(CHEMBL426387 | [(3R)-5-bromo-4-(4-chlorobenzyl)-7-...)
Affinity DataKi:  0.840nMAssay Description:Binding affinity to human TP receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50205276(CHEMBL385126 | [(3R)-4-(4-chlorobenzyl)-7-fluoro-5...)
Affinity DataKi:  1.10nMAssay Description:Binding affinity to human DP receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50205274(CHEMBL426387 | [(3R)-5-bromo-4-(4-chlorobenzyl)-7-...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity to human DP receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50184217(2-((R)-4-(4-chlorobenzyl)-5-(1-hydroxyethyl)-7-(me...)
Affinity DataKi:  1.80nMAssay Description:Binding affinity to human DP receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50184212((R)-2-(4-(4-chlorobenzyl)-5-acetyl-7-(methylsulfon...)
Affinity DataKi:  2.60nMAssay Description:Binding affinity to human DP receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane A2 receptor(Homo sapiens (Human))
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50205275(CHEMBL426559 | [(3R)-4-(4-chlorobenzyl)-7-fluoro-5...)
Affinity DataKi:  3nMAssay Description:Binding affinity to human TP receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131975(1-(2-Methylamino-3-phenyl-propionyl)-pyrrolidine-2...)
Affinity DataKi:  3.10nMAssay Description:In vitro inhibition of bovine trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131980(1-Acetyl-pyrrolidine-2-carboxylic acid [1-(benzoth...)
Affinity DataKi:  4nMAssay Description:In vitro inhibition of bovine trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131977(1-Acetyl-4-hydroxy-pyrrolidine-2-carboxylic acid [...)
Affinity DataKi:  6nMAssay Description:In vitro inhibition of bovine trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131975(1-(2-Methylamino-3-phenyl-propionyl)-pyrrolidine-2...)
Affinity DataKi:  6.5nMAssay Description:In vitro inhibition of human Tryptase beta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131982(2-Acetylamino-4-methyl-pentanoic acid [1-(benzothi...)
Affinity DataKi:  7nMAssay Description:In vitro inhibition of bovine trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50205278(2-(4-(4-chlorobenzyl)-7-fluoro-5-(methylsulfonyl)-...)
Affinity DataKi:  8.90nMAssay Description:Binding affinity to human DP receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131989(1-Acetyl-2,5-dihydro-1H-pyrrole-2-carboxylic acid ...)
Affinity DataKi:  9.10nMAssay Description:In vitro inhibition of bovine trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50205277((S)-2-(4-(4-chlorobenzyl)-7-fluoro-5-(methylsulfon...)
Affinity DataKi:  9.60nMAssay Description:Binding affinity to human DP receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131983(1-Acetyl-4-oxo-pyrrolidine-2-carboxylic acid [1-(b...)
Affinity DataKi:  9.90nMAssay Description:In vitro inhibition of bovine trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane A2 receptor(Homo sapiens (Human))
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50205276(CHEMBL385126 | [(3R)-4-(4-chlorobenzyl)-7-fluoro-5...)
Affinity DataKi:  14nMAssay Description:Binding affinity to human TP receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131985(1-Acetyl-4-hydroxy-pyrrolidine-2-carboxylic acid [...)
Affinity DataKi:  16nMAssay Description:In vitro inhibition of bovine trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131980(1-Acetyl-pyrrolidine-2-carboxylic acid [1-(benzoth...)
Affinity DataKi:  19nMAssay Description:In vitro inhibition of human Tryptase beta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131984(1-Acetyl-azetidine-2-carboxylic acid [1-(benzothia...)
Affinity DataKi:  20nMAssay Description:In vitro inhibition of human Tryptase beta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131977(1-Acetyl-4-hydroxy-pyrrolidine-2-carboxylic acid [...)
Affinity DataKi:  22nMAssay Description:In vitro inhibition of human Tryptase beta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131979(CHEMBL340547 | Cyclopentanecarboxylic acid [1-(ben...)
Affinity DataKi:  30nMAssay Description:In vitro inhibition of bovine trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131988(2-[1-(Benzothiazole-2-carbonyl)-4-guanidino-butylc...)
Affinity DataKi:  33nMAssay Description:In vitro inhibition of human Tryptase beta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131989(1-Acetyl-2,5-dihydro-1H-pyrrole-2-carboxylic acid ...)
Affinity DataKi:  38nMAssay Description:In vitro inhibition of human Tryptase beta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131988(2-[1-(Benzothiazole-2-carbonyl)-4-guanidino-butylc...)
Affinity DataKi:  38nMAssay Description:In vitro inhibition of bovine trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131982(2-Acetylamino-4-methyl-pentanoic acid [1-(benzothi...)
Affinity DataKi:  41nMAssay Description:In vitro inhibition of human Tryptase beta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131984(1-Acetyl-azetidine-2-carboxylic acid [1-(benzothia...)
Affinity DataKi:  53nMAssay Description:In vitro inhibition of bovine trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131983(1-Acetyl-4-oxo-pyrrolidine-2-carboxylic acid [1-(b...)
Affinity DataKi:  73nMAssay Description:In vitro inhibition of human Tryptase beta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131974(1-Acetyl-4-hydroxy-pyrrolidine-2-carboxylic acid [...)
Affinity DataKi:  81nMAssay Description:In vitro inhibition of bovine trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131979(CHEMBL340547 | Cyclopentanecarboxylic acid [1-(ben...)
Affinity DataKi:  88nMAssay Description:In vitro inhibition of human Tryptase beta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131985(1-Acetyl-4-hydroxy-pyrrolidine-2-carboxylic acid [...)
Affinity DataKi:  90nMAssay Description:In vitro inhibition of human Tryptase beta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM16127(2,2 -methanediylbis(1H-benzimidazole-6-carboximida...)
Affinity DataKi:  100nMAssay Description:In vitro inhibition of bovine trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP2 subtype(Homo sapiens (Human))
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50205275(CHEMBL426559 | [(3R)-4-(4-chlorobenzyl)-7-fluoro-5...)
Affinity DataKi:  136nMAssay Description:Binding affinity to human EP2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM16127(2,2 -methanediylbis(1H-benzimidazole-6-carboximida...)
Affinity DataKi:  140nMAssay Description:In vitro inhibition of human Tryptase beta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131978(1-Benzyl-pyrrolidine-2-carboxylic acid [1-(benzoth...)
Affinity DataKi:  160nMAssay Description:In vitro inhibition of bovine trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131977(1-Acetyl-4-hydroxy-pyrrolidine-2-carboxylic acid [...)
Affinity DataKi:  170nMAssay Description:In vitro inhibition of bovine trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131977(1-Acetyl-4-hydroxy-pyrrolidine-2-carboxylic acid [...)
Affinity DataKi:  170nMAssay Description:In vitro inhibition of bovine trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131974(1-Acetyl-4-hydroxy-pyrrolidine-2-carboxylic acid [...)
Affinity DataKi:  180nMAssay Description:In vitro inhibition of human Tryptase beta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP2 subtype(Homo sapiens (Human))
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50184212((R)-2-(4-(4-chlorobenzyl)-5-acetyl-7-(methylsulfon...)
Affinity DataKi:  230nMAssay Description:Binding affinity to human EP2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131978(1-Benzyl-pyrrolidine-2-carboxylic acid [1-(benzoth...)
Affinity DataKi:  250nMAssay Description:In vitro inhibition of human Tryptase beta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131981(CHEMBL340098 | N-{[1-(Benzothiazole-2-carbonyl)-4-...)
Affinity DataKi:  260nMAssay Description:In vitro inhibition of bovine trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP2 subtype(Homo sapiens (Human))
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50205276(CHEMBL385126 | [(3R)-4-(4-chlorobenzyl)-7-fluoro-5...)
Affinity DataKi:  310nMAssay Description:Binding affinity to human EP2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131987(1-{5-Guanidino-2-[(1-hydroxy-naphthalene-2-carbony...)
Affinity DataKi:  330nMAssay Description:In vitro inhibition of human Tryptase beta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131977(1-Acetyl-4-hydroxy-pyrrolidine-2-carboxylic acid [...)
Affinity DataKi:  380nMAssay Description:In vitro inhibition of human Tryptase beta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131977(1-Acetyl-4-hydroxy-pyrrolidine-2-carboxylic acid [...)
Affinity DataKi:  380nMAssay Description:In vitro inhibition of human Tryptase beta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP2 subtype(Homo sapiens (Human))
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50184217(2-((R)-4-(4-chlorobenzyl)-5-(1-hydroxyethyl)-7-(me...)
Affinity DataKi:  390nMAssay Description:Binding affinity to human EP2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstacyclin receptor(Homo sapiens (Human))
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50205274(CHEMBL426387 | [(3R)-5-bromo-4-(4-chlorobenzyl)-7-...)
Affinity DataKi:  400nMAssay Description:Binding affinity to human IP receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP2 subtype(Homo sapiens (Human))
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50205274(CHEMBL426387 | [(3R)-5-bromo-4-(4-chlorobenzyl)-7-...)
Affinity DataKi:  410nMAssay Description:Binding affinity to human EP2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50205274(CHEMBL426387 | [(3R)-5-bromo-4-(4-chlorobenzyl)-7-...)
Affinity DataKi:  470nMAssay Description:Binding affinity to human EP3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131981(CHEMBL340098 | N-{[1-(Benzothiazole-2-carbonyl)-4-...)
Affinity DataKi:  470nMAssay Description:In vitro inhibition of human Tryptase beta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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