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Found 63 with Last Name = 'abrams' and Initial = 'k'
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50176377((R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)...)
Affinity DataIC50:  1nMAssay Description:Inhibition of PAF mediated human eosinophil chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50176377((R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)...)
Affinity DataIC50:  1nMAssay Description:Inhibition of C5a mediated human eosinophil chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50176377((R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)...)
Affinity DataIC50: <1nMAssay Description:Inhibition of PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50176377((R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)...)
Affinity DataIC50:  2nMAssay Description:Inhibition of release of LTE4 in human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50176377((R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)...)
Affinity DataIC50:  3nMAssay Description:Inhibition of Eotaxin mediated by human eosinophil chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50176377((R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)...)
Affinity DataIC50:  4nMAssay Description:Inhibition of PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataIC50:  11nMAssay Description:Inhibition of PDE4AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataIC50:  33nMAssay Description:Inhibition of PDE4DMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataIC50:  34nMAssay Description:Inhibition of PDE4BMore data for this Ligand-Target Pair
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50176521(5-methyl-6-oxo-6,7-dihydro-5H-furo[2,3-f]indole-7-...)
Affinity DataIC50:  40nMAssay Description:Inhibitory activity against PDE2 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataIC50:  41nMAssay Description:Inhibition of release of LTE4 in human whole bloodMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataIC50:  41nMAssay Description:Inhibition of release of LTE4 in human whole bloodMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50176377((R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)...)
Affinity DataIC50:  107nMAssay Description:Inhibition of PDE4AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50176377((R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)...)
Affinity DataIC50:  185nMAssay Description:Inhibition of PDE4BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataIC50:  625nMAssay Description:Inhibition of release of TNF alpha in human whole bloodMore data for this Ligand-Target Pair
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM28393((+)-EHNA | (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-...)
Affinity DataIC50:  635nMAssay Description:Inhibitory activity against PDE2 by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50176377((R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)...)
Affinity DataIC50:  925nMAssay Description:Inhibition of release of TNF alpha in human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50176377((R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)...)
Affinity DataIC50:  1.38E+3nMAssay Description:Inhibition of PDE4CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of PAF mediated human eosinophil chemotaxisMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataIC50:  3.41E+3nMAssay Description:Inhibition of PDE4CMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataIC50:  6.50E+3nMAssay Description:Inhibition of LTB4 mediated human eosinophil chemotaxisMore data for this Ligand-Target Pair
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50176521(5-methyl-6-oxo-6,7-dihydro-5H-furo[2,3-f]indole-7-...)
Affinity DataIC50:  1.16E+4nMAssay Description:Inhibitory activity against PDE11 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50176377((R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)...)
Affinity DataIC50: >1.60E+4nMAssay Description:Inhibition of PDE8AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50176377((R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)...)
Affinity DataIC50: >1.60E+4nMAssay Description:Inhibition of PDE2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataIC50: >1.60E+4nMAssay Description:Inhibition of PDE9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataIC50: >1.60E+4nMAssay Description:Inhibition of PDE2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataIC50: >1.60E+4nMAssay Description:Inhibition of PDE10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50176377((R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)...)
Affinity DataIC50: >1.60E+4nMAssay Description:Inhibition of PDE8BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28393((+)-EHNA | (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-...)
Affinity DataIC50: >1.60E+4nMAssay Description:Inhibitory activity against PDE8A by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataIC50: >1.60E+4nMAssay Description:Inhibition of PDE8BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM28393((+)-EHNA | (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-...)
Affinity DataIC50: >1.60E+4nMAssay Description:Inhibitory activity against PDE3 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM28393((+)-EHNA | (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-...)
Affinity DataIC50: >1.60E+4nMAssay Description:Inhibitory activity against PDE11 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50176521(5-methyl-6-oxo-6,7-dihydro-5H-furo[2,3-f]indole-7-...)
Affinity DataIC50: >1.60E+4nMAssay Description:Inhibitory activity against PDE5 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50176521(5-methyl-6-oxo-6,7-dihydro-5H-furo[2,3-f]indole-7-...)
Affinity DataIC50: >1.60E+4nMAssay Description:Inhibitory activity against PDE3 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50176521(5-methyl-6-oxo-6,7-dihydro-5H-furo[2,3-f]indole-7-...)
Affinity DataIC50: >1.60E+4nMAssay Description:Inhibitory activity against PDE1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM28393((+)-EHNA | (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-...)
Affinity DataIC50: >1.60E+4nMAssay Description:Inhibitory activity against PDE5 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28393((+)-EHNA | (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-...)
Affinity DataIC50: >1.60E+4nMAssay Description:Inhibitory activity against PDE1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataIC50: >1.60E+4nMAssay Description:Inhibition of PDE11More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataIC50: >1.60E+4nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataIC50: >1.60E+4nMAssay Description:Inhibition of PDE3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50176377((R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)...)
Affinity DataIC50: >1.60E+4nMAssay Description:Inhibition of PDE3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50176377((R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)...)
Affinity DataIC50: >1.60E+4nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50176377((R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)...)
Affinity DataIC50: >1.60E+4nMAssay Description:Inhibition of PDE10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50176521(5-methyl-6-oxo-6,7-dihydro-5H-furo[2,3-f]indole-7-...)
Affinity DataIC50: >1.60E+4nMAssay Description:Inhibitory activity against PDE8B by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM28393((+)-EHNA | (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-...)
Affinity DataIC50: >1.60E+4nMAssay Description:Inhibitory activity against PDE9 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50176377((R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)...)
Affinity DataIC50: >1.60E+4nMAssay Description:Inhibition of PDE9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataIC50: >1.60E+4nMAssay Description:Inhibition of PDE8AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM28393((+)-EHNA | (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-...)
Affinity DataIC50: >1.60E+4nMAssay Description:Inhibitory activity against PDE4D by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50176521(5-methyl-6-oxo-6,7-dihydro-5H-furo[2,3-f]indole-7-...)
Affinity DataIC50: >1.60E+4nMAssay Description:Inhibitory activity against PDE10 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM28393((+)-EHNA | (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-...)
Affinity DataIC50: >1.60E+4nMAssay Description:Inhibitory activity against PDE4C by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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