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Found 191 with Last Name = 'acton' and Initial = 'b'
TargetPoly(ADP-ribose) glycohydrolase(Homo sapiens (Human))
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50508416(CHEMBL4518815)
Affinity DataIC50:  20nMAssay Description:Inhibition of recombinant full-length human C-terminal His6-tagged PARG (1 to 976 residues) expressed in Escherichia coli BL21 (DE3) cells using 6HIS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly(ADP-ribose) glycohydrolase(Homo sapiens (Human))
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50508415(CHEMBL4459798)
Affinity DataIC50:  20nMAssay Description:Inhibition of recombinant full-length human C-terminal His6-tagged PARG (1 to 976 residues) expressed in Escherichia coli BL21 (DE3) cells using 6HIS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly(ADP-ribose) glycohydrolase(Homo sapiens (Human))
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50508413(CHEMBL4459166)
Affinity DataIC50:  30nMAssay Description:Inhibition of recombinant full-length human C-terminal His6-tagged PARG (1 to 976 residues) expressed in Escherichia coli BL21 (DE3) cells using 6HIS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly(ADP-ribose) glycohydrolase(Homo sapiens (Human))
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50508413(CHEMBL4459166)
Affinity DataIC50:  70nMAssay Description:Inhibition of PARG in human HeLa cells assessed as induction of MMS-induced PAR chains preincubated for 1 hr followed by MMS addition and measured af...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly(ADP-ribose) glycohydrolase(Homo sapiens (Human))
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM371184(US10239843, Example 291)
Affinity DataIC50:  80nMAssay Description:Inhibition of PARG in human HeLa cells assessed as induction of MMS-induced PAR chains preincubated for 1 hr followed by MMS addition and measured af...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly(ADP-ribose) glycohydrolase(Homo sapiens (Human))
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM371331(1-Ethyl-N-[1-(fluoromethyl)cyclopropyl]-3-[(1-meth...)
Affinity DataIC50:  80nMAssay Description:Inhibition of PARG in human HeLa cells assessed as induction of MMS-induced PAR chains preincubated for 1 hr followed by MMS addition and measured af...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly(ADP-ribose) glycohydrolase(Homo sapiens (Human))
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50508416(CHEMBL4518815)
Affinity DataIC50:  90nMAssay Description:Inhibition of PARG in human HeLa cells assessed as induction of MMS-induced PAR chains preincubated for 1 hr followed by MMS addition and measured af...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly(ADP-ribose) glycohydrolase(Homo sapiens (Human))
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM371331(1-Ethyl-N-[1-(fluoromethyl)cyclopropyl]-3-[(1-meth...)
Affinity DataIC50:  100nMAssay Description:Inhibition of recombinant full-length human C-terminal His6-tagged PARG (1 to 976 residues) expressed in Escherichia coli BL21 (DE3) cells using 6HIS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly(ADP-ribose) glycohydrolase(Homo sapiens (Human))
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50508415(CHEMBL4459798)
Affinity DataIC50:  170nMAssay Description:Inhibition of PARG in human HeLa cells assessed as induction of MMS-induced PAR chains preincubated for 1 hr followed by MMS addition and measured af...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly(ADP-ribose) glycohydrolase(Homo sapiens (Human))
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM371184(US10239843, Example 291)
Affinity DataIC50:  170nMAssay Description:Inhibition of recombinant full-length human C-terminal His6-tagged PARG (1 to 976 residues) expressed in Escherichia coli BL21 (DE3) cells using 6HIS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly(ADP-ribose) glycohydrolase(Homo sapiens (Human))
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM371301(N-[1-(Fluoromethyl)cyclopropyl]-1-methyl-3-[(1-met...)
Affinity DataIC50:  290nMAssay Description:Inhibition of PARG in human HeLa cells assessed as induction of MMS-induced PAR chains preincubated for 1 hr followed by MMS addition and measured af...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly(ADP-ribose) glycohydrolase(Homo sapiens (Human))
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50508414(CHEMBL4456850)
Affinity DataIC50:  320nMAssay Description:Inhibition of recombinant full-length human C-terminal His6-tagged PARG (1 to 976 residues) expressed in Escherichia coli BL21 (DE3) cells using 6HIS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly(ADP-ribose) glycohydrolase(Homo sapiens (Human))
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM371048(US10239843, Example 155 | US10239843, Example 489)
Affinity DataIC50:  330nMAssay Description:Inhibition of PARG in human HeLa cells assessed as induction of MMS-induced PAR chains preincubated for 1 hr followed by MMS addition and measured af...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly(ADP-ribose) glycohydrolase(Homo sapiens (Human))
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM371048(US10239843, Example 155 | US10239843, Example 489)
Affinity DataIC50:  390nMAssay Description:Inhibition of recombinant full-length human C-terminal His6-tagged PARG (1 to 976 residues) expressed in Escherichia coli BL21 (DE3) cells using 6HIS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly(ADP-ribose) glycohydrolase(Homo sapiens (Human))
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM371301(N-[1-(Fluoromethyl)cyclopropyl]-1-methyl-3-[(1-met...)
Affinity DataIC50:  630nMAssay Description:Inhibition of recombinant full-length human C-terminal His6-tagged PARG (1 to 976 residues) expressed in Escherichia coli BL21 (DE3) cells using 6HIS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly(ADP-ribose) glycohydrolase(Homo sapiens (Human))
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50508414(CHEMBL4456850)
Affinity DataIC50:  1.25E+3nMAssay Description:Inhibition of PARG in human HeLa cells assessed as induction of MMS-induced PAR chains preincubated for 1 hr followed by MMS addition and measured af...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly(ADP-ribose) glycohydrolase(Homo sapiens (Human))
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50508418(CHEMBL4555002)
Affinity DataIC50:  1.52E+3nMAssay Description:Inhibition of recombinant full-length human C-terminal His6-tagged PARG (1 to 976 residues) expressed in Escherichia coli BL21 (DE3) cells using 6HIS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly(ADP-ribose) glycohydrolase(Homo sapiens (Human))
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50508417(CHEMBL4451386)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibition of recombinant full-length human C-terminal His6-tagged PARG (1 to 976 residues) expressed in Escherichia coli BL21 (DE3) cells using 6HIS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly(ADP-ribose) glycohydrolase(Homo sapiens (Human))
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50508417(CHEMBL4451386)
Affinity DataIC50:  4.10E+3nMAssay Description:Inhibition of PARG in human HeLa cells assessed as induction of MMS-induced PAR chains preincubated for 1 hr followed by MMS addition and measured af...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly(ADP-ribose) glycohydrolase(Homo sapiens (Human))
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50508418(CHEMBL4555002)
Affinity DataIC50:  6.60E+3nMAssay Description:Inhibition of PARG in human HeLa cells assessed as induction of MMS-induced PAR chains preincubated for 1 hr followed by MMS addition and measured af...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM371190(US10239843, Example 297)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM371190(US10239843, Example 297)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM371190(US10239843, Example 297)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM371190(US10239843, Example 297)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM371190(US10239843, Example 297)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP1A (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM371198(US10239843, Example 305)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM371198(US10239843, Example 305)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP1A (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM371198(US10239843, Example 305)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM371198(US10239843, Example 305)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM371198(US10239843, Example 305)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly(ADP-ribose) glycohydrolase(Homo sapiens (Human))
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50466566(CHEMBL4283645)
Affinity DataEC50: >1.50E+5nMAssay Description:Inhibition of human full length PARG using Bt-NAD ribosylated PARP1 substrate after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly(ADP-ribose) glycohydrolase(Homo sapiens (Human))
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50466567(CHEMBL3115335)
Affinity DataEC50:  5.00E+4nMAssay Description:Inhibition of human full length PARG using Bt-NAD ribosylated PARP1 substrate after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly(ADP-ribose) glycohydrolase(Homo sapiens (Human))
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM370932(US10239843, Example 39)
Affinity DataEC50:  710nMAssay Description:Inhibition of human full length PARG using Bt-NAD ribosylated PARP1 substrate after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly(ADP-ribose) glycohydrolase(Homo sapiens (Human))
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM370977(US10239843, Example 84)
Affinity DataEC50:  2.40E+3nMAssay Description:Inhibition of human full length PARG using Bt-NAD ribosylated PARP1 substrate after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly(ADP-ribose) glycohydrolase(Homo sapiens (Human))
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM371421(1-Methyl-N-(1-methylcyclopropyl)-2,4-dioxo-3-phena...)
Affinity DataEC50:  1.60E+3nMAssay Description:Inhibition of human full length PARG using Bt-NAD ribosylated PARP1 substrate after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly(ADP-ribose) glycohydrolase(Homo sapiens (Human))
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM371401(3-(Isothiazol-5-ylmethyl)-1-methyl-N-(1-methylcycl...)
Affinity DataEC50:  2.30E+3nMAssay Description:Inhibition of human full length PARG using Bt-NAD ribosylated PARP1 substrate after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly(ADP-ribose) glycohydrolase(Homo sapiens (Human))
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM371110(US10239843, Example 217)
Affinity DataEC50:  370nMAssay Description:Inhibition of human full length PARG using Bt-NAD ribosylated PARP1 substrate after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly(ADP-ribose) glycohydrolase(Homo sapiens (Human))
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM371063(US10239843, Example 170)
Affinity DataEC50:  6nMAssay Description:Inhibition of human full length PARG using Bt-NAD ribosylated PARP1 substrate after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly(ADP-ribose) glycohydrolase(Homo sapiens (Human))
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM205478(PDD00013907 (1))
Affinity DataEC50:  3.00E+4nMAssay Description:Inhibition of PARG in human HeLa cells assessed as induction of MMS-induced PAR chains preincubated for 1 hr followed by MMS addition and measured af...More data for this Ligand-Target Pair
TargetPoly(ADP-ribose) glycohydrolase(Homo sapiens (Human))
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM370927(US10239843, Example 34)
Affinity DataEC50:  2.70E+3nMAssay Description:Inhibition of PARG in human HeLa cells assessed as induction of MMS-induced PAR chains preincubated for 1 hr followed by MMS addition and measured af...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly(ADP-ribose) glycohydrolase(Homo sapiens (Human))
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM371198(US10239843, Example 305)
Affinity DataEC50:  280nMAssay Description:Inhibition of PARG in human HeLa cells assessed as induction of MMS-induced PAR chains preincubated for 1 hr followed by MMS addition and measured af...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetADP-ribosylhydrolase ARH3(Homo sapiens (Human))
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM371049(US10239843, Example 156)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of human full length C-terminus His-tagged ARH3 expressed in Escherichia coli using Bt-NAD ribosylated PARP1 substrate after 30 mins by TR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly(ADP-ribose) glycohydrolase(Homo sapiens (Human))
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM371125(3-[(2-Aminothiazol-5-yl)methyl]-1-methyl-N-(1-meth...)
Affinity DataEC50:  480nMAssay Description:Inhibition of human full length PARG using Bt-NAD ribosylated PARP1 substrate after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly(ADP-ribose) glycohydrolase(Homo sapiens (Human))
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50466568(CHEMBL4288328)
Affinity DataEC50: >7.00E+4nMAssay Description:Inhibition of human full length PARG using Bt-NAD ribosylated PARP1 substrate after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetPoly(ADP-ribose) glycohydrolase(Homo sapiens (Human))
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50466569(CHEMBL4291914)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition of human full length PARG using Bt-NAD ribosylated PARP1 substrate after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly(ADP-ribose) glycohydrolase(Homo sapiens (Human))
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50466570(CHEMBL4286999)
Affinity DataEC50:  8.80E+4nMAssay Description:Inhibition of human full length PARG using Bt-NAD ribosylated PARP1 substrate after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly(ADP-ribose) glycohydrolase(Homo sapiens (Human))
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50466571(CHEMBL4278148)
Affinity DataEC50:  4.00E+3nMAssay Description:Inhibition of human full length PARG using Bt-NAD ribosylated PARP1 substrate after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly(ADP-ribose) glycohydrolase(Homo sapiens (Human))
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50466572(CHEMBL4286783)
Affinity DataEC50:  380nMAssay Description:Inhibition of human full length PARG using Bt-NAD ribosylated PARP1 substrate after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly(ADP-ribose) glycohydrolase(Homo sapiens (Human))
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM371008(US10239843, Example 115)
Affinity DataEC50:  620nMAssay Description:Inhibition of human full length PARG using Bt-NAD ribosylated PARP1 substrate after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly(ADP-ribose) glycohydrolase(Homo sapiens (Human))
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM371091(US10239843, Example 198)
Affinity DataEC50:  100nMAssay Description:Inhibition of human full length PARG using Bt-NAD ribosylated PARP1 substrate after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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