TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Albert Einstein College Of Medicine
Curated by ChEMBL
Albert Einstein College Of Medicine
Curated by ChEMBL
Affinity DataIC50: 0.160nMAssay Description:Inhibition of full length human 6His-tagged BRAF V600E mutant expressed in baculovirus infected insect cells co-expressing human CDC37 (1 to 378 resi...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Albert Einstein College Of Medicine
Curated by ChEMBL
Albert Einstein College Of Medicine
Curated by ChEMBL
Affinity DataIC50: 0.170nMAssay Description:Inhibition of BRAF V600E mutant in human MALME-3M cellsMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Albert Einstein College Of Medicine
Curated by ChEMBL
Albert Einstein College Of Medicine
Curated by ChEMBL
Affinity DataIC50: 0.400nMAssay Description:Inhibition of BRAF V600E mutant (unknown origin) by Z'-LYTE assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Albert Einstein College Of Medicine
Curated by ChEMBL
Albert Einstein College Of Medicine
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Inhibition of BRAF V600E mutant in human A375 cells assessed as reduction in ERK phosphorylation after 2 hrs by ELISAMore data for this Ligand-Target Pair
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Albert Einstein College Of Medicine
Curated by ChEMBL
Albert Einstein College Of Medicine
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Inhibition of CRAF (unknown origin) by Z'-LYTE assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Albert Einstein College Of Medicine
Curated by ChEMBL
Albert Einstein College Of Medicine
Curated by ChEMBL
Affinity DataIC50: 0.800nMAssay Description:Inhibition of BRAF V600E mutant (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Albert Einstein College Of Medicine
Curated by ChEMBL
Albert Einstein College Of Medicine
Curated by ChEMBL
Affinity DataIC50: 0.800nMAssay Description:Inhibition of wild type BRAF (unknown origin) by Z'-LYTE assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Albert Einstein College Of Medicine
Curated by ChEMBL
Albert Einstein College Of Medicine
Curated by ChEMBL
Affinity DataIC50: 3.5nMAssay Description:Inhibition of BRAF V600E mutant in human A375 cells assessed as reduction in ERK phosphorylation by AlphaScreen assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Albert Einstein College Of Medicine
Curated by ChEMBL
Albert Einstein College Of Medicine
Curated by ChEMBL
Affinity DataIC50: 3.80nMAssay Description:Inhibition of N-terminal His-tagged BRAF V600E mutant (unknown origin) expressed in baculovirus infected insect cells co-expressing CDC37 using bioti...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Albert Einstein College Of Medicine
Curated by ChEMBL
Albert Einstein College Of Medicine
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of BRAF V600E mutant in human A375 cells assessed as reduction in ERK phosphorylation by Western blot analysisMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Albert Einstein College Of Medicine
Curated by ChEMBL
Albert Einstein College Of Medicine
Curated by ChEMBL
Affinity DataIC50: 4.20nMAssay Description:Inhibition of N-terminal His-tagged BRAF V600E mutant (unknown origin) expressed in baculovirus infected insect cells co-expressing CDC37 using bioti...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Albert Einstein College Of Medicine
Curated by ChEMBL
Albert Einstein College Of Medicine
Curated by ChEMBL
Affinity DataIC50: 4.40nMAssay Description:Inhibition of BRAF V600E mutant in human A375 cells assessed as reduction in ERK phosphorylationMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Albert Einstein College Of Medicine
Curated by ChEMBL
Albert Einstein College Of Medicine
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of BRAF V600E mutant in human A375 cells assessed as reduction in ERK phosphorylationMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Albert Einstein College Of Medicine
Curated by ChEMBL
Albert Einstein College Of Medicine
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of BRAF V600E mutant in human A375 cells assessed as reduction in ERK phosphorylationMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase A-Raf(Homo sapiens (Human))
Albert Einstein College Of Medicine
Curated by ChEMBL
Albert Einstein College Of Medicine
Curated by ChEMBL
Affinity DataIC50: 5.60nMAssay Description:Inhibition of ARAF (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Albert Einstein College Of Medicine
Curated by ChEMBL
Albert Einstein College Of Medicine
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of BRAF V600E mutant (unknown origin)More data for this Ligand-Target Pair
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Albert Einstein College Of Medicine
Curated by ChEMBL
Albert Einstein College Of Medicine
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of CRAF (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Albert Einstein College Of Medicine
Curated by ChEMBL
Albert Einstein College Of Medicine
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of N-terminal His-tagged BRAF V600E mutant (unknown origin) expressed in baculovirus infected insect cells co-expressing CDC37 using bioti...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Albert Einstein College Of Medicine
Curated by ChEMBL
Albert Einstein College Of Medicine
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of BRAF V600E mutant (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Albert Einstein College Of Medicine
Curated by ChEMBL
Albert Einstein College Of Medicine
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of BRAF V600E mutant in human A375 cells assessed as reduction in ERK phosphorylationMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Albert Einstein College Of Medicine
Curated by ChEMBL
Albert Einstein College Of Medicine
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of BRAF V600E mutant in human A375 cells assessed as reduction in ERK phosphorylation by AlphaScreen assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Albert Einstein College Of Medicine
Curated by ChEMBL
Albert Einstein College Of Medicine
Curated by ChEMBL
Affinity DataIC50: 22nMAssay Description:Inhibition of recombinant BRAF (409 to 765 residues) (unknown origin) using MEK1 as substrate after 25 mins in presence of gamma-[33P]ATPMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Albert Einstein College Of Medicine
Curated by ChEMBL
Albert Einstein College Of Medicine
Curated by ChEMBL
Affinity DataIC50: 23nMAssay Description:Inhibition of BRAF V600E mutant (unknown origin) using MEK1 as substrate preincubated for 60 to 120 mins followed by substrate addition measured afte...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Albert Einstein College Of Medicine
Curated by ChEMBL
Albert Einstein College Of Medicine
Curated by ChEMBL
Affinity DataIC50: 31nMAssay Description:Inhibition of N-terminal His-tagged BRAF V600E mutant (unknown origin) expressed in baculovirus infected insect cells co-expressing CDC37 using bioti...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Albert Einstein College Of Medicine
Curated by ChEMBL
Albert Einstein College Of Medicine
Curated by ChEMBL
Affinity DataIC50: 32nMAssay Description:Inhibition of BRAF V600E mutant in human A375 cells assessed as reduction in ERK phosphorylation by AlphaScreen assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Albert Einstein College Of Medicine
Curated by ChEMBL
Albert Einstein College Of Medicine
Curated by ChEMBL
Affinity DataIC50: 32nMAssay Description:Inhibition of wild type BRAF (unknown origin) using MEK1 as substrate preincubated for 60 to 120 mins followed by substrate addition measured after 2...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Albert Einstein College Of Medicine
Curated by ChEMBL
Albert Einstein College Of Medicine
Curated by ChEMBL
Affinity DataIC50: 34nMAssay Description:Inhibition of human His-tagged BRAF V600E mutant (513 to 693 residues) using inactive MEK as substrate after 30 mins by immunoblotting analysisMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Albert Einstein College Of Medicine
Curated by ChEMBL
Albert Einstein College Of Medicine
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of BRAF V600E mutant (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Albert Einstein College Of Medicine
Curated by ChEMBL
Albert Einstein College Of Medicine
Curated by ChEMBL
Affinity DataIC50: 44nMAssay Description:Inhibition of BRAF V600E mutant in human A375 cells assessed as reduction in ERK phosphorylation by AlphaScreen assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Albert Einstein College Of Medicine
Curated by ChEMBL
Albert Einstein College Of Medicine
Curated by ChEMBL
Affinity DataIC50: 64nMAssay Description:Inhibition of BRAF V600E mutant in human A375 cells assessed as reduction in ERK phosphorylation after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Albert Einstein College Of Medicine
Curated by ChEMBL
Albert Einstein College Of Medicine
Curated by ChEMBL
Affinity DataIC50: 70nMAssay Description:Inhibition of BRAF V600E mutant in human PLGA cells assessed as reduction in ERK phosphorylation after 1 hr by mass spectrometric analysisMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Albert Einstein College Of Medicine
Curated by ChEMBL
Albert Einstein College Of Medicine
Curated by ChEMBL
Affinity DataIC50: 157nMAssay Description:Inhibition of BRAF V600E mutant in human SK-MEL-239 cells assessed as reduction in ERK phosphorylation after 1 hr by Western blot analysisMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Albert Einstein College Of Medicine
Curated by ChEMBL
Albert Einstein College Of Medicine
Curated by ChEMBL
Affinity DataIC50: 290nMAssay Description:Inhibition of BRAF V600E mutant in human A375 cells assessed as reduction in ERK phosphorylation by immunoblot analysisMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Albert Einstein College Of Medicine
Curated by ChEMBL
Albert Einstein College Of Medicine
Curated by ChEMBL
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of BRAF V600E mutant in human A375 cells assessed as reduction in ERK phosphorylation by ELISAMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Albert Einstein College Of Medicine
Curated by ChEMBL
Albert Einstein College Of Medicine
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of BRAF in human Jurkat T cells assessed as reduction in ERK phosphorylationMore data for this Ligand-Target Pair