Compile Data Set for Download or QSAR
maximum 50k data
Found 110 with Last Name = 'akwabi-ameyaw' and Initial = 'a'
TargetEstrogen receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]estradiol from full length biotinylated human ERalpha by scintillation proximity assayMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]estradiol from full length biotinylated human ERalpha by scintillation proximity assayMore data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]estradiol from full length biotinylated human ERbeta by scintillation proximity assayMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50264124(3-(4-(6-hydroxy-3-pentyl-2-phenylnaphthalen-1-ylox...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]estradiol from full length biotinylated human ERalpha by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50264124(3-(4-(6-hydroxy-3-pentyl-2-phenylnaphthalen-1-ylox...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]estradiol from full length biotinylated human ERbeta by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50264122(3-(4-(3-butyl-6-hydroxy-2-phenylnaphthalen-1-yloxy...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]estradiol from full length biotinylated human ERalpha by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50264122(3-(4-(3-butyl-6-hydroxy-2-phenylnaphthalen-1-yloxy...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]estradiol from full length biotinylated human ERbeta by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50264121(3-(4-(3-cyclopropyl-6-hydroxy-2-phenylnaphthalen-1...)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]estradiol from full length biotinylated human ERbeta by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50264123(3-(4-(6-hydroxy-3-isobutyl-2-phenylnaphthalen-1-yl...)
Affinity DataKi:  22nMAssay Description:Displacement of [3H]estradiol from full length biotinylated human ERbeta by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataKi:  23nMAssay Description:Displacement of [3H]estradiol from full length biotinylated human ERbeta by scintillation proximity assayMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50264123(3-(4-(6-hydroxy-3-isobutyl-2-phenylnaphthalen-1-yl...)
Affinity DataKi:  28nMAssay Description:Displacement of [3H]estradiol from full length biotinylated human ERalpha by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50264172(3-(4-(6-hydroxy-3-octyl-2-phenylnaphthalen-1-yloxy...)
Affinity DataKi:  30nMAssay Description:Displacement of [3H]estradiol from full length biotinylated human ERbeta by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50264695(3-(4-(3-butyl-2-(4-hydroxyphenyl)naphthalen-1-ylox...)
Affinity DataKi:  48nMAssay Description:Displacement of [3H]estradiol from full length biotinylated human ERbeta by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50264695(3-(4-(3-butyl-2-(4-hydroxyphenyl)naphthalen-1-ylox...)
Affinity DataKi:  52nMAssay Description:Displacement of [3H]estradiol from full length biotinylated human ERalpha by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50264172(3-(4-(6-hydroxy-3-octyl-2-phenylnaphthalen-1-yloxy...)
Affinity DataKi:  55nMAssay Description:Displacement of [3H]estradiol from full length biotinylated human ERalpha by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50264121(3-(4-(3-cyclopropyl-6-hydroxy-2-phenylnaphthalen-1...)
Affinity DataKi:  60nMAssay Description:Displacement of [3H]estradiol from full length biotinylated human ERalpha by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50264693(3-(4-(3-butyl-2-(4-fluorophenyl)naphthalen-1-yloxy...)
Affinity DataKi:  110nMAssay Description:Displacement of [3H]estradiol from full length biotinylated human ERbeta by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50264694(3-(4-(3-butyl-2-(4-methoxyphenyl)naphthalen-1-ylox...)
Affinity DataKi:  158nMAssay Description:Displacement of [3H]estradiol from full length biotinylated human ERalpha by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50264694(3-(4-(3-butyl-2-(4-methoxyphenyl)naphthalen-1-ylox...)
Affinity DataKi:  162nMAssay Description:Displacement of [3H]estradiol from full length biotinylated human ERbeta by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50264692(3-(4-(3-butyl-2-phenylnaphthalen-1-yloxy)phenyl)ac...)
Affinity DataKi:  170nMAssay Description:Displacement of [3H]estradiol from full length biotinylated human ERbeta by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50264660(3-(4-(3-(methoxymethyl)-2-phenylnaphthalen-1-yloxy...)
Affinity DataKi:  501nMAssay Description:Displacement of [3H]estradiol from full length biotinylated human ERbeta by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50264660(3-(4-(3-(methoxymethyl)-2-phenylnaphthalen-1-yloxy...)
Affinity DataKi:  692nMAssay Description:Displacement of [3H]estradiol from full length biotinylated human ERalpha by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50264693(3-(4-(3-butyl-2-(4-fluorophenyl)naphthalen-1-yloxy...)
Affinity DataKi:  724nMAssay Description:Displacement of [3H]estradiol from full length biotinylated human ERalpha by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50264692(3-(4-(3-butyl-2-phenylnaphthalen-1-yloxy)phenyl)ac...)
Affinity DataKi:  977nMAssay Description:Displacement of [3H]estradiol from full length biotinylated human ERalpha by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Gsk

LigandPNGBDBM21724(3-[(E)-2-(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-(1...)
Affinity DataEC50:  59nMpH: 7.5 T: 2°CAssay Description:The assay measures ligand-mediated interaction of the SRC-1 peptide with the FXR ligand binding domain, using biotinylated FXR LBD coupled to allophy...More data for this Ligand-Target Pair
TargetBile acid receptor(Homo sapiens (Human))
Gsk

LigandPNGBDBM30329(Naphthoic acid-based analog, 1b)
Affinity DataEC50:  87nMpH: 7.5 T: 2°CAssay Description:The assay measures ligand-mediated interaction of the SRC-1 peptide with the FXR ligand binding domain, using biotinylated FXR LBD coupled to allophy...More data for this Ligand-Target Pair
TargetBile acid receptor(Homo sapiens (Human))
Gsk

LigandPNGBDBM30330(Naphthoic acid-based analog, 1c)
Affinity DataEC50:  100nMpH: 7.5 T: 2°CAssay Description:The assay measures ligand-mediated interaction of the SRC-1 peptide with the FXR ligand binding domain, using biotinylated FXR LBD coupled to allophy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Gsk

LigandPNGBDBM30331(Naphthoic acid-based analog, 1d)
Affinity DataEC50:  420nMpH: 7.5 T: 2°CAssay Description:The assay measures ligand-mediated interaction of the SRC-1 peptide with the FXR ligand binding domain, using biotinylated FXR LBD coupled to allophy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Gsk

LigandPNGBDBM30332(Naphthoic acid-based analog, 1e)
Affinity DataEC50:  2.30E+3nMpH: 7.5 T: 2°CAssay Description:The assay measures ligand-mediated interaction of the SRC-1 peptide with the FXR ligand binding domain, using biotinylated FXR LBD coupled to allophy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Gsk

LigandPNGBDBM21724(3-[(E)-2-(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-(1...)
Affinity DataEC50:  65nMAssay Description:The cell-based assay measures the ligand-mediated luminescense resulting from FXR-induced transcription of a luciferase reporter. FXR and the lucifer...More data for this Ligand-Target Pair
TargetBile acid receptor(Homo sapiens (Human))
Gsk

LigandPNGBDBM30329(Naphthoic acid-based analog, 1b)
Affinity DataEC50:  68nMAssay Description:The cell-based assay measures the ligand-mediated luminescense resulting from FXR-induced transcription of a luciferase reporter. FXR and the lucifer...More data for this Ligand-Target Pair
TargetBile acid receptor(Homo sapiens (Human))
Gsk

LigandPNGBDBM30330(Naphthoic acid-based analog, 1c)
Affinity DataEC50:  45nMAssay Description:The cell-based assay measures the ligand-mediated luminescense resulting from FXR-induced transcription of a luciferase reporter. FXR and the lucifer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Gsk

LigandPNGBDBM30331(Naphthoic acid-based analog, 1d)
Affinity DataEC50:  500nMAssay Description:The cell-based assay measures the ligand-mediated luminescense resulting from FXR-induced transcription of a luciferase reporter. FXR and the lucifer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Gsk

LigandPNGBDBM30332(Naphthoic acid-based analog, 1e)
Affinity DataEC50:  3.30E+3nMAssay Description:The cell-based assay measures the ligand-mediated luminescense resulting from FXR-induced transcription of a luciferase reporter. FXR and the lucifer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Gsk

LigandPNGBDBM21724(3-[(E)-2-(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-(1...)
Affinity DataEC50:  59nMAssay Description:Induction of SRC1 coactivator peptide binding to ligand binding domain of human FXR by FRET assayMore data for this Ligand-Target Pair
TargetBile acid receptor(Homo sapiens (Human))
Gsk

LigandPNGBDBM21724(3-[(E)-2-(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-(1...)
Affinity DataEC50:  65nMAssay Description:Increase in human FXR-mediated transient transcription of luciferase reporter gene transfected in african green monkey CV1 cellsMore data for this Ligand-Target Pair
TargetBile acid receptor(Homo sapiens (Human))
Gsk

LigandPNGBDBM50297939(3-[5-({[3-(2,6-Dichlorophenyl)-5-(1-methylethyl)-4...)
Affinity DataEC50:  55nMAssay Description:Induction of SRC1 coactivator peptide binding to ligand binding domain of human FXR by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Gsk

LigandPNGBDBM50297939(3-[5-({[3-(2,6-Dichlorophenyl)-5-(1-methylethyl)-4...)
Affinity DataEC50:  32nMAssay Description:Increase in human FXR-mediated transient transcription of luciferase reporter gene transfected in african green monkey CV1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Gsk

LigandPNGBDBM50297940(4-[5-({[3-(2,6-Dichlorophenyl)-5-(1-methylethyl)-4...)
Affinity DataEC50:  280nMAssay Description:Induction of SRC1 coactivator peptide binding to ligand binding domain of human FXR by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Gsk

LigandPNGBDBM50297940(4-[5-({[3-(2,6-Dichlorophenyl)-5-(1-methylethyl)-4...)
Affinity DataEC50:  160nMAssay Description:Increase in human FXR-mediated transient transcription of luciferase reporter gene transfected in african green monkey CV1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Gsk

LigandPNGBDBM50297941(3-(6-{[3-(2,6-dichlorophenyl)-5-(1-methylethyl)iso...)
Affinity DataEC50:  140nMAssay Description:Induction of SRC1 coactivator peptide binding to ligand binding domain of human FXR by FRET assayMore data for this Ligand-Target Pair
TargetBile acid receptor(Homo sapiens (Human))
Gsk

LigandPNGBDBM50297941(3-(6-{[3-(2,6-dichlorophenyl)-5-(1-methylethyl)iso...)
Affinity DataEC50:  63nMAssay Description:Increase in human FXR-mediated transient transcription of luciferase reporter gene transfected in african green monkey CV1 cellsMore data for this Ligand-Target Pair
TargetBile acid receptor(Homo sapiens (Human))
Gsk

LigandPNGBDBM50297942(4-[6-({[3-(2,6-Dichlorophenyl)-5-(1-methylethyl)-4...)
Affinity DataEC50:  200nMAssay Description:Induction of SRC1 coactivator peptide binding to ligand binding domain of human FXR by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Gsk

LigandPNGBDBM50297942(4-[6-({[3-(2,6-Dichlorophenyl)-5-(1-methylethyl)-4...)
Affinity DataEC50:  220nMAssay Description:Increase in human FXR-mediated transient transcription of luciferase reporter gene transfected in african green monkey CV1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Gsk

LigandPNGBDBM50297943(3-[6-({[3-(2,6-Dichlorophenyl)-5-(1-methylethyl)-4...)
Affinity DataEC50:  410nMAssay Description:Induction of SRC1 coactivator peptide binding to ligand binding domain of human FXR by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Gsk

LigandPNGBDBM50297943(3-[6-({[3-(2,6-Dichlorophenyl)-5-(1-methylethyl)-4...)
Affinity DataEC50:  410nMAssay Description:Increase in human FXR-mediated transient transcription of luciferase reporter gene transfected in african green monkey CV1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Gsk

LigandPNGBDBM50297944(3-[5-({[3-(2,6-Dichlorophenyl)-5-(1-methylethyl)-4...)
Affinity DataEC50:  480nMAssay Description:Induction of SRC1 coactivator peptide binding to ligand binding domain of human FXR by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Gsk

LigandPNGBDBM50297944(3-[5-({[3-(2,6-Dichlorophenyl)-5-(1-methylethyl)-4...)
Affinity DataEC50:  630nMAssay Description:Increase in human FXR-mediated transient transcription of luciferase reporter gene transfected in african green monkey CV1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Gsk

LigandPNGBDBM50297945(3-(6-((3-(2,6-dichlorophenyl)-5-isopropylisoxazol-...)
Affinity DataEC50:  110nMAssay Description:Induction of SRC1 coactivator peptide binding to ligand binding domain of human FXR by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Gsk

LigandPNGBDBM50297945(3-(6-((3-(2,6-dichlorophenyl)-5-isopropylisoxazol-...)
Affinity DataEC50:  130nMAssay Description:Increase in human FXR-mediated transient transcription of luciferase reporter gene transfected in african green monkey CV1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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