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Found 214 with Last Name = 'ala' and Initial = 'pj'
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM13465((2S)-N-[(1S)-1-carbamoyl-2-{4-[(5S)-1,1,3-trioxo-1...)
Affinity DataKi:  180nMAssay Description:Inhibition constant against protein-tyrosine phosphatase 1B by PNPP enzyme assayMore data for this Ligand-Target Pair
LigandPNGBDBM13467((2R)-2-{[(1S)-1-carbamoyl-2-{4-[difluoro(phosphono...)
Affinity DataIC50:  0.400nMpH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM13469(({4-[(2S)-2-carbamoyl-2-[(2S)-2-(1-{4-[difluoro(ph...)
Affinity DataIC50:  1.70nMpH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50189670(5-{4-[(2S)-2-(5-chloro-1H-benzimidazol-2-yl)-2-({[...)
Affinity DataIC50:  10nMAssay Description:Inhibition of PTP1B by pNPP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50189686(CHEMBL381584 | N-(1S)-1-(1H-benzimidazol-2-yl)-2-{...)
Affinity DataIC50:  15nMAssay Description:Inhibition of PTP1B by pNPP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50189659(CHEMBL378614 | N-((1S)-1-(1H-benzimidazol-2-yl)-2-...)
Affinity DataIC50:  16nMAssay Description:Inhibition of PTP1B by pNPP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50189656(CHEMBL208114 | N-{(1S)-1-(1H-benzimidazol-2-yl)-2-...)
Affinity DataIC50:  18nMAssay Description:Inhibition of PTP1B by pNPP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50189687(CHEMBL211352 | N-((1S)-1-(1H-benzimidazol-2-yl)-2-...)
Affinity DataIC50:  18nMAssay Description:Inhibition of PTP1B by pNPP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50228014(2-[4-((R)-2-{1-(3-fluoro-benzenesulfonylamino)-2-[...)
Affinity DataIC50:  22nMAssay Description:Inhibition of PTP1B by pNPP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50228013(3-fluoro-N-{1-{(R)-5-[2-(3-methanesulfonyl-phenoxy...)
Affinity DataIC50:  23nMAssay Description:Inhibition of PTP1B by pNPP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50228024(3-fluoro-N-{1-[5-(3-phenyl-propyl)-1H-imidazol-2-y...)
Affinity DataIC50:  24nMAssay Description:Inhibition of TCPTP by pNPP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50228013(3-fluoro-N-{1-{(R)-5-[2-(3-methanesulfonyl-phenoxy...)
Affinity DataIC50:  25nMAssay Description:Inhibition of TCPTP by pNPP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM13507(Isothiazolidinone (IZD) deriv. 43 | N-[(1S)-1-(1H-...)
Affinity DataIC50:  31nMAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50228008(2-[4-(2-{1-(3-fluoro-benzenesulfonylamino)-2-[3-me...)
Affinity DataIC50:  32nMAssay Description:Inhibition of PTP1B by pNPP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50189642(CHEMBL210836 | N-(1S)-1-(1H-benzimidazol-2yl)-2-4-...)
Affinity DataIC50:  32nMAssay Description:Inhibition of PTP1B by pNPP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM13508(Isothiazolidinone (IZD) deriv. 44 | N-[(1S)-1-(1H-...)
Affinity DataIC50:  34nMAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14269((S)-isothiazolidinone | IZD deriv. 2 | N-[(1S)-1-(...)
Affinity DataIC50:  35nMpH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50189640(CHEMBL377989 | N-((1S)-1-(1H-benzimidazol-2-yl)-2-...)
Affinity DataIC50:  35nMAssay Description:Inhibition of PTP1B by pNPP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14268((2S)-N-[(1S)-1-(1H-1,3-benzodiazol-2-yl)-2-{4-[(5S...)
Affinity DataIC50:  35nMpH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM14268((2S)-N-[(1S)-1-(1H-1,3-benzodiazol-2-yl)-2-{4-[(5S...)
Affinity DataIC50:  35nMAssay Description:Inhibition of PTP1B by pNPP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50228038(3-fluoro-N-{1-[(R)-5-(2-fluoro-benzyl)-4,5-dihydro...)
Affinity DataIC50:  38nMAssay Description:Inhibition of TCPTP by pNPP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM13493(Isothiazolidinone (IZD) deriv. 29 | N-[(1S)-1-(1H-...)
Affinity DataIC50:  40nMAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM13471(({4-[(2S)-2-carbamoyl-2-[2-(1-{4-[difluoro(phospho...)
Affinity DataIC50:  42nMpH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50228024(3-fluoro-N-{1-[5-(3-phenyl-propyl)-1H-imidazol-2-y...)
Affinity DataIC50:  43nMAssay Description:Inhibition of PTP1B by pNPP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50189635(CHEMBL424880 | N-((1S)-1-(1H-benzimidazol-2yl)-2-4...)
Affinity DataIC50:  43nMAssay Description:Inhibition of PTP1B by pNPP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50189675(CHEMBL436933 | N-{1-(1H-benzoimidazol-2-yl)-2-[4-(...)
Affinity DataIC50:  43nMAssay Description:Inhibition of TCPTP by pNPP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50189649(CHEMBL212260 | N-{1-(1H-benzoimidazol-2-yl)-2-[4-(...)
Affinity DataIC50:  45nMAssay Description:Inhibition of PTP1B by pNPP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM13470(Difluoromethylphosphonic acid (DFMP) deriv. 9 | [(...)
Affinity DataIC50:  46nMpH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50228014(2-[4-((R)-2-{1-(3-fluoro-benzenesulfonylamino)-2-[...)
Affinity DataIC50:  46nMAssay Description:Inhibition of TCPTP by pNPP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50228008(2-[4-(2-{1-(3-fluoro-benzenesulfonylamino)-2-[3-me...)
Affinity DataIC50:  46nMAssay Description:Inhibition of TCPTP by pNPP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50189658(CHEMBL377735 | N-{1-(1H-benzoimidazol-2-yl)-2-[4-(...)
Affinity DataIC50:  48nMAssay Description:Inhibition of PTP1B by pNPP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50189657(CHEMBL208604 | N-(1S)-1-(1H-benzimidazol-2-yl)-2-{...)
Affinity DataIC50:  50nMAssay Description:Inhibition of PTP1B by pNPP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50228036(CHEMBL253269 | N-{1-[5-(3-phenyl-propyl)-1H-imidaz...)
Affinity DataIC50:  51nMAssay Description:Inhibition of TCPTP by pNPP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50189688(CHEMBL206950 | N-{1-(1H-benzoimidazol-2-yl)-2-[4-(...)
Affinity DataIC50:  51nMAssay Description:Inhibition of PTP1B by pNPP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50189655(CHEMBL207489 | N-{1-(1H-benzoimidazol-2-yl)-2-[4-(...)
Affinity DataIC50:  51nMAssay Description:Inhibition of PTP1B by pNPP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM13494(Isothiazolidinone (IZD) deriv. 30 | N-[(1S)-1-(1H-...)
Affinity DataIC50:  51nMAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50228036(CHEMBL253269 | N-{1-[5-(3-phenyl-propyl)-1H-imidaz...)
Affinity DataIC50:  52nMAssay Description:Inhibition of PTP1B by pNPP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50189647(CHEMBL264833 | biphenyl-4-sulfonic acid {1-(5-cyan...)
Affinity DataIC50:  53nMAssay Description:Inhibition of PTP1B by pNPP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM13475(Isothiazolidinone (IZD) deriv. 4 | N-[(1S)-1-(1H-1...)
Affinity DataIC50:  59nMpH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
LigandPNGBDBM13509(Isothiazolidinone (IZD) deriv. 45 | N-[(1S)-1-(1H-...)
Affinity DataIC50:  59nMAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50189648(CHEMBL212147 | N-{1-(1H-benzoimidazol-2-yl)-2-[4-(...)
Affinity DataIC50:  60nMAssay Description:Inhibition of PTP1B by pNPP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50228032(CHEMBL403908 | N-{1-(5-phenyl-1H-imidazol-2-yl)-2-...)
Affinity DataIC50:  61nMAssay Description:Inhibition of TCPTP by pNPP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50189673(CHEMBL383437 | N-{1-(1H-benzoimidazol-2-yl)-2-[4-(...)
Affinity DataIC50:  63nMAssay Description:Inhibition of PTP1B by pNPP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50228038(3-fluoro-N-{1-[(R)-5-(2-fluoro-benzyl)-4,5-dihydro...)
Affinity DataIC50:  64nMAssay Description:Inhibition of PTP1B by pNPP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50228025(2-[4-((R)-2-{1-(3-fluoro-benzenesulfonylamino)-2-[...)
Affinity DataIC50:  65nMAssay Description:Inhibition of TCPTP by pNPP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM13809((2S)-N-[(1S)-1-carbamoyl-2-[4-(1,1,3-trioxo-2,3-di...)
Affinity DataIC50:  65nMpH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
LigandPNGBDBM13495(Isothiazolidinone (IZD) deriv. 31 | N-[(1S)-1-(1H-...)
Affinity DataIC50:  66nMAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50189675(CHEMBL436933 | N-{1-(1H-benzoimidazol-2-yl)-2-[4-(...)
Affinity DataIC50:  67nMAssay Description:Inhibition of PTP1B by pNPP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50189675(CHEMBL436933 | N-{1-(1H-benzoimidazol-2-yl)-2-[4-(...)
Affinity DataIC50:  67nMAssay Description:Inhibition of PTP1B by pNPP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50228039(3-fluoro-N-{1-((R)-5-phenethyl-4,5-dihydro-1H-imid...)
Affinity DataIC50:  68nMAssay Description:Inhibition of TCPTP by pNPP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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