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Found 191 with Last Name = 'allgeier' and Initial = 'h'
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50198702((E)-3-((6-methylpyridin-2-yl)ethynyl)cyclohex-2-en...)
Affinity DataKi:  1.70nMAssay Description:Displacement of [3H]ABP688 from human mGluR5 receptor expressed in L (tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50198702((E)-3-((6-methylpyridin-2-yl)ethynyl)cyclohex-2-en...)
Affinity DataKi:  1.80nMAssay Description:Displacement of [3H]ABP688 from mGluR5 in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50198702((E)-3-((6-methylpyridin-2-yl)ethynyl)cyclohex-2-en...)
Affinity DataKi:  3.5nMAssay Description:Displacement of [3H]M-MPEP from human mGluR5 receptor expressed in L (tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50123005(2-(3-Methoxy-phenylethynyl)-6-methyl-pyridine | 2-...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]ABP688 from human mGluR5 receptor expressed in L (tk-) cellsMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50123005(2-(3-Methoxy-phenylethynyl)-6-methyl-pyridine | 2-...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]ABP688 from mGluR5 in rat brain membraneMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50084137(2-Methyl-6-(phenylethynyl)pyridine | 2-Methyl-6-ph...)
Affinity DataKi:  19nMAssay Description:Displacement of [3H]ABP688 from mGluR5 in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50084137(2-Methyl-6-(phenylethynyl)pyridine | 2-Methyl-6-ph...)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]ABP688 from human mGluR5 receptor expressed in L (tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50094186((-)1aS,7aS -2-Hydroxyimino-1a,2-dihydro-1H-7-oxa-c...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]ABP688 from mGluR5 in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50094186((-)1aS,7aS -2-Hydroxyimino-1a,2-dihydro-1H-7-oxa-c...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]ABP688 from human mGluR5 receptor expressed in L (tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
Ingenium Pharmaceuticals

US Patent
LigandPNGBDBM120943(US8716296, 89)
Affinity DataIC50:  0.00500nMpH: 7.5Assay Description:All kinase assays were performed in 96-well FlashPlates from Perkin Elmer/NEN (Boston, Mass., USA) in a 50 μl reaction volume. The reaction mixt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
Ingenium Pharmaceuticals

US Patent
LigandPNGBDBM120941(US8716296, 82)
Affinity DataIC50:  0.0150nMpH: 7.5Assay Description:All kinase assays were performed in 96-well FlashPlates from Perkin Elmer/NEN (Boston, Mass., USA) in a 50 μl reaction volume. The reaction mixt...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
Ingenium Pharmaceuticals

US Patent
LigandPNGBDBM120934(US8716296, 2)
Affinity DataIC50:  0.0180nMpH: 7.5Assay Description:All kinase assays were performed in 96-well FlashPlates from Perkin Elmer/NEN (Boston, Mass., USA) in a 50 μl reaction volume. The reaction mixt...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
Ingenium Pharmaceuticals

US Patent
LigandPNGBDBM120936(US8716296, 5 | US8716296, 6)
Affinity DataIC50:  0.0190nMpH: 7.5Assay Description:All kinase assays were performed in 96-well FlashPlates from Perkin Elmer/NEN (Boston, Mass., USA) in a 50 μl reaction volume. The reaction mixt...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
Ingenium Pharmaceuticals

US Patent
LigandPNGBDBM120942(US8716296, 83)
Affinity DataIC50:  0.0290nMpH: 7.5Assay Description:All kinase assays were performed in 96-well FlashPlates from Perkin Elmer/NEN (Boston, Mass., USA) in a 50 μl reaction volume. The reaction mixt...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
Ingenium Pharmaceuticals

US Patent
LigandPNGBDBM120935(US8716296, 3)
Affinity DataIC50:  0.0390nMpH: 7.5Assay Description:All kinase assays were performed in 96-well FlashPlates from Perkin Elmer/NEN (Boston, Mass., USA) in a 50 μl reaction volume. The reaction mixt...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
Ingenium Pharmaceuticals

US Patent
LigandPNGBDBM120939(US8716296, 52)
Affinity DataIC50:  0.116nMpH: 7.5Assay Description:All kinase assays were performed in 96-well FlashPlates from Perkin Elmer/NEN (Boston, Mass., USA) in a 50 μl reaction volume. The reaction mixt...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
Ingenium Pharmaceuticals

US Patent
LigandPNGBDBM120936(US8716296, 5 | US8716296, 6)
Affinity DataIC50:  0.173nMpH: 7.5Assay Description:All kinase assays were performed in 96-well FlashPlates from Perkin Elmer/NEN (Boston, Mass., USA) in a 50 μl reaction volume. The reaction mixt...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutamate receptor ionotropic, NMDA 1/2A(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50451503(CHEMBL12513)
Affinity DataIC50:  0.200nMAssay Description:Inhibitory activity against Xenopus laevis oocyte expressing 1A/2B heteromeric human NMDA (hNMDA) receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50451505(CHEMBL274422)
Affinity DataIC50:  0.700nMAssay Description:Inhibitory activity against Xenopus laevis oocyte expressing 1A/2B heteromeric human NMDA (hNMDA) receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
Ingenium Pharmaceuticals

US Patent
LigandPNGBDBM120940(US8716296, 53)
Affinity DataIC50:  1.08nMpH: 7.5Assay Description:All kinase assays were performed in 96-well FlashPlates from Perkin Elmer/NEN (Boston, Mass., USA) in a 50 μl reaction volume. The reaction mixt...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutamate receptor ionotropic, NMDA 1/2A(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50451505(CHEMBL274422)
Affinity DataIC50:  1.10nMAssay Description:Inhibitory activity against Xenopus laevis oocyte expressing 1A/2B heteromeric human NMDA (hNMDA) receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
Ingenium Pharmaceuticals

US Patent
LigandPNGBDBM120938(US8716296, 51)
Affinity DataIC50:  1.25nMpH: 7.5Assay Description:All kinase assays were performed in 96-well FlashPlates from Perkin Elmer/NEN (Boston, Mass., USA) in a 50 μl reaction volume. The reaction mixt...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50451503(CHEMBL12513)
Affinity DataIC50:  1.80nMAssay Description:Inhibitory activity against Xenopus laevis oocyte expressing 1A/2A heteromeric human NMDA (hNMDA) receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50198702((E)-3-((6-methylpyridin-2-yl)ethynyl)cyclohex-2-en...)
Affinity DataIC50:  2.30nMAssay Description:Activity at human recombinant mGluR5 expressed in L(tk-) cells assessed as inhibition of glutamate-induced calcium releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50198702((E)-3-((6-methylpyridin-2-yl)ethynyl)cyclohex-2-en...)
Affinity DataIC50:  2.40nMAssay Description:Activity at human recombinant mGluR5 expressed in L(tk-) cells assessed as inhibition of quisqualate-induced phosphoinositol accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50451498(CHEMBL536107)
Affinity DataIC50:  4.20nMAssay Description:Inhibitory activity against Xenopus laevis oocyte expressing 1A/2B heteromeric human NMDA (hNMDA) receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50198702((E)-3-((6-methylpyridin-2-yl)ethynyl)cyclohex-2-en...)
Affinity DataIC50:  7nMAssay Description:Displacement of [3H]M-MPEP from human mGluR5 receptor expressed in L (tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50069471(CHEMBL357190 | N-(7-Bromo-2,3-dioxo-1,2,3,4-tetrah...)
Affinity DataIC50:  7nMAssay Description:In vitro binding assay for the displacement of [3H]MDL-105519 from the glycine-site of NMDA receptorsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
Ingenium Pharmaceuticals

US Patent
LigandPNGBDBM120933(US8716296, 1)
Affinity DataIC50:  10nMpH: 7.5Assay Description:All kinase assays were performed in 96-well FlashPlates from Perkin Elmer/NEN (Boston, Mass., USA) in a 50 μl reaction volume. The reaction mixt...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50069483(CHEMBL356281 | N-(7-Bromo-2,3-dioxo-1,2,3,4-tetrah...)
Affinity DataIC50:  10nMAssay Description:In vitro binding assay for the displacement of [3H]MDL-105519 from the glycine-site of NMDA receptorsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50069482(CHEMBL357916 | N-(7-Bromo-2,3-dioxo-1,2,3,4-tetrah...)
Affinity DataIC50:  10nMAssay Description:In vitro binding assay for the displacement of [3H]MDL-105519 from the glycine-site of NMDA receptorsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50069465(CHEMBL343863 | Thiophene-2-carboxylic acid (7-brom...)
Affinity DataIC50:  10nMAssay Description:In vitro binding assay for the displacement of [3H]MDL-105519 from the glycine-site of NMDA receptorsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50069459(CHEMBL413125 | Thiophene-3-carboxylic acid (7-brom...)
Affinity DataIC50:  10nMAssay Description:In vitro binding assay for the displacement of [3H]MDL-105519 from the glycine-site of NMDA receptorsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50069458(CHEMBL147895 | N-(7-Bromo-2,3-dioxo-1,2,3,4-tetrah...)
Affinity DataIC50:  10nMAssay Description:In vitro binding assay for the displacement of [3H]MDL-105519 from the glycine-site of NMDA receptorsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50069495(CHEMBL147894 | N-(7-Chloro-2,3-dioxo-1,2,3,4-tetra...)
Affinity DataIC50:  10nMAssay Description:In vitro binding assay for the displacement of [3H]MDL-105519 from the glycine-site of NMDA receptorsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50451509(CHEMBL268920)
Affinity DataIC50:  18nMAssay Description:Inhibitory activity against Xenopus laevis oocyte expressing 1A/2B heteromeric human NMDA (hNMDA) receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50069478(3-Methyl-thiophene-2-carboxylic acid (7-bromo-2,3-...)
Affinity DataIC50:  20nMAssay Description:In vitro binding assay for the displacement of [3H]MDL-105519 from the glycine-site of NMDA receptorsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50069456(1-Methyl-1H-pyrrole-2-carboxylic acid (7-bromo-2,3...)
Affinity DataIC50:  20nMAssay Description:In vitro binding assay for the displacement of [3H]MDL-105519 from the glycine-site of NMDA receptorsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50069461(CHEMBL357447 | N-(7-Bromo-2,3-dioxo-1,2,3,4-tetrah...)
Affinity DataIC50:  20nMAssay Description:In vitro binding assay for the displacement of [3H]MDL-105519 from the glycine-site of NMDA receptorsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50069470(CHEMBL145606 | N-(7-Bromo-2,3-dioxo-1,2,3,4-tetrah...)
Affinity DataIC50:  30nMAssay Description:In vitro binding assay for the displacement of [3H]MDL-105519 from the glycine-site of NMDA receptorsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50069491(1-(2-Methoxy-phenyl)-3-(7-nitro-2,3-dioxo-1,2,3,4-...)
Affinity DataIC50:  30nMAssay Description:In vitro binding assay for the displacement of [3H]MDL-105519 from the glycine-site of NMDA receptorsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50069479(5-Methyl-thiophene-2-carboxylic acid (7-bromo-2,3-...)
Affinity DataIC50:  30nMAssay Description:In vitro binding assay for the displacement of [3H]MDL-105519 from the glycine-site of NMDA receptorsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50069488(1-(4-Methoxy-phenyl)-3-(7-nitro-2,3-dioxo-1,2,3,4-...)
Affinity DataIC50:  30nMAssay Description:In vitro binding assay for the displacement of [3H]MDL-105519 from the glycine-site of NMDA receptorsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50451498(CHEMBL536107)
Affinity DataIC50:  34nMAssay Description:Inhibitory activity against Xenopus laevis oocyte expressing 1A/2B heteromeric human NMDA (hNMDA) receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50069464(CHEMBL144064 | Furan-2-carboxylic acid (7-bromo-2,...)
Affinity DataIC50:  40nMAssay Description:In vitro binding assay for the displacement of [3H]MDL-105519 from the glycine-site of NMDA receptorsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50069460(CHEMBL144365 | N-(7-Nitro-2,3-dioxo-1,2,3,4-tetrah...)
Affinity DataIC50:  40nMAssay Description:In vitro binding assay for the displacement of [3H]MDL-105519 from the glycine-site of NMDA receptorsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50451518(CHEMBL12256)
Affinity DataIC50:  40nMAssay Description:Inhibitory activity against Xenopus laevis oocyte expressing 1A/2B heteromeric human NMDA (hNMDA) receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50069467(Acetic acid [(7-bromo-2,3-dioxo-1,2,3,4-tetrahydro...)
Affinity DataIC50:  40nMAssay Description:In vitro binding assay for the displacement of [3H]MDL-105519 from the glycine-site of NMDA receptorsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50069497(CHEMBL146827 | N-(7-Bromo-2,3-dioxo-1,2,3,4-tetrah...)
Affinity DataIC50:  40nMAssay Description:In vitro binding assay for the displacement of [3H]MDL-105519 from the glycine-site of NMDA receptorsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50069490(CHEMBL147855 | N-(7-Bromo-2,3-dioxo-1,2,3,4-tetrah...)
Affinity DataIC50:  40nMAssay Description:In vitro binding assay for the displacement of [3H]MDL-105519 from the glycine-site of NMDA receptorsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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