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Found 363 with Last Name = 'alves' and Initial = 'm'
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Federal University Of Alfenas

Curated by ChEMBL
LigandPNGBDBM50590554(CHEMBL5183556)
Affinity DataKi:  1.95E+3nMAssay Description:Inhibition of Electrophorus electricus AchE assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Federal University Of Alfenas

Curated by ChEMBL
LigandPNGBDBM50590549(CHEMBL5175519)
Affinity DataKi:  3.56E+3nMAssay Description:Inhibition of Electrophorus electricus AchE assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Federal University Of Alfenas

Curated by ChEMBL
LigandPNGBDBM50590558(CHEMBL5204385)
Affinity DataKi:  3.81E+3nMAssay Description:Inhibition of Electrophorus electricus AchE assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Universidade Federal De Pernambuco

Curated by ChEMBL
LigandPNGBDBM50320887(3-(2-Chloro-6-fluoro-benzyl)-5-(2,4-dichlorobenzyl...)
Affinity DataKi:  4.00E+3nMAssay Description:Displacement of [3H]rosiglitazone from human PPARgamma ligand binding domain expressed in Escherichia coli BL21 after 12 hrs by liquid scintillation ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Federal University Of Alfenas

Curated by ChEMBL
LigandPNGBDBM50590552(CHEMBL5170874)
Affinity DataKi:  6.24E+3nMAssay Description:Inhibition of Electrophorus electricus AchE assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Universidade Federal De Pernambuco

Curated by ChEMBL
LigandPNGBDBM50320886(3-(2-Bromo-benzyl)-5-(4-methanesulfonyl-benzyliden...)
Affinity DataKi:  7.30E+3nMAssay Description:Displacement of [3H]rosiglitazone from human PPARgamma ligand binding domain expressed in Escherichia coli BL21 after 12 hrs by liquid scintillation ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Universidade Federal De Pernambuco

Curated by ChEMBL
LigandPNGBDBM50320884(3-(3-Chloro-benzyl)-5-(4-methanesulfonyl-benzylide...)
Affinity DataKi:  4.30E+4nMAssay Description:Displacement of [3H]rosiglitazone from human PPARgamma ligand binding domain expressed in Escherichia coli BL21 after 12 hrs by liquid scintillation ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Universidade Federal De Pernambuco

Curated by ChEMBL
LigandPNGBDBM50320885(5-Bipheny-4-ylmethylene-3-(3-chloro-benzyl)-thiazo...)
Affinity DataKi:  4.36E+4nMAssay Description:Displacement of [3H]rosiglitazone from human PPARgamma ligand binding domain expressed in Escherichia coli BL21 after 12 hrs by liquid scintillation ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM10246((4S)-4-{[(1S)-1-{[(2S)-1-carboxy-3-oxopropan-2-yl]...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of human recombinant caspase 3 assessed as fluorescent 7-amido-4-methylcoumarin releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPapain(Carica papaya)
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50157741(CHEMBL374508 | E-64 | E64)
Affinity DataIC50:  2nMAssay Description:Inhibition of papaya papain using Z-Leu-Leu-Arg-AMC as substrate after 30 mins by spectrofluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Rattus norvegicus)
Universidade Federal Do Piau£

Curated by ChEMBL
LigandPNGBDBM21642((2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolid...)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of Wistar rat plasma angiotensin 1-converting enzyme using H-hippuryl-His-Leu-OH as substrate after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPapain(Carica papaya)
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50157741(CHEMBL374508 | E-64 | E64)
Affinity DataIC50:  7nMAssay Description:Inhibition of papaya papain using Z-Leu-Leu-Arg-AMC as substrate after 30 mins by fluorescence microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Universidade De Lisboa

Curated by ChEMBL
LigandPNGBDBM50084637(2,2-Dimethyl-propionic acid 4-[2-(carboxymethyl-ca...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human neutrophil elastase using MeO-Suc-Ala-Ala-Pro-Val-AMC as substrate incubated for 30 mins prior to substrate addition measured for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Federal University Of Alfenas

Curated by ChEMBL
LigandPNGBDBM8960((+/-)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimet...)
Affinity DataIC50:  30nMAssay Description:Inhibition of Electrophorus electricus AchE using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition by sp...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCaspase-7(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM10246((4S)-4-{[(1S)-1-{[(2S)-1-carboxy-3-oxopropan-2-yl]...)
Affinity DataIC50:  59.1nMAssay Description:Inhibition of human recombinant caspase 7 assessed as fluorescent 7-amido-4-methylcoumarin releaseMore data for this Ligand-Target Pair
TargetNeutrophil elastase(Homo sapiens (Human))
Universidade De Lisboa

Curated by ChEMBL
LigandPNGBDBM50444295(CHEMBL3093806)
Affinity DataIC50:  80nMAssay Description:Inhibition of human neutrophil elastase using MeO-Suc-Ala-Ala-Pro-Val-AMC as substrate incubated for 30 mins prior to substrate addition measured for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Universidade De Lisboa

Curated by ChEMBL
LigandPNGBDBM50444297(CHEMBL3093815)
Affinity DataIC50:  110nMAssay Description:Inhibition of human neutrophil elastase using MeO-Suc-Ala-Ala-Pro-Val-AMC as substrate incubated for 30 mins prior to substrate addition measured for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Universidade De Lisboa

Curated by ChEMBL
LigandPNGBDBM50444296(CHEMBL3093814)
Affinity DataIC50:  180nMAssay Description:Inhibition of human neutrophil elastase using MeO-Suc-Ala-Ala-Pro-Val-AMC as substrate incubated for 30 mins prior to substrate addition measured for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Universidade De Lisboa

Curated by ChEMBL
LigandPNGBDBM50444300(CHEMBL3093808)
Affinity DataIC50:  280nMAssay Description:Inhibition of human neutrophil elastase using MeO-Suc-Ala-Ala-Pro-Val-AMC as substrate incubated for 30 mins prior to substrate addition measured for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Universidade De Lisboa

Curated by ChEMBL
LigandPNGBDBM50444301(CHEMBL3093809)
Affinity DataIC50:  300nMAssay Description:Inhibition of human neutrophil elastase using MeO-Suc-Ala-Ala-Pro-Val-AMC as substrate incubated for 30 mins prior to substrate addition measured for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Universidade De Lisboa

Curated by ChEMBL
LigandPNGBDBM50444312(CHEMBL3093821)
Affinity DataIC50:  450nMAssay Description:Inhibition of human neutrophil elastase using MeO-Suc-Ala-Ala-Pro-Val-AMC as substrate incubated for 30 mins prior to substrate addition measured for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Universidade De Lisboa

Curated by ChEMBL
LigandPNGBDBM50444307(CHEMBL3093816)
Affinity DataIC50:  670nMAssay Description:Inhibition of human neutrophil elastase using MeO-Suc-Ala-Ala-Pro-Val-AMC as substrate incubated for 30 mins prior to substrate addition measured for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Universidade De Lisboa

Curated by ChEMBL
LigandPNGBDBM50444302(CHEMBL3093810)
Affinity DataIC50:  960nMAssay Description:Inhibition of human neutrophil elastase using MeO-Suc-Ala-Ala-Pro-Val-AMC as substrate incubated for 30 mins prior to substrate addition measured for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Universidade De Lisboa

Curated by ChEMBL
LigandPNGBDBM50444306(CHEMBL3091487)
Affinity DataIC50:  1.19E+3nMAssay Description:Inhibition of human neutrophil elastase using MeO-Suc-Ala-Ala-Pro-Val-AMC as substrate incubated for 30 mins prior to substrate addition measured for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Universidade De Lisboa

Curated by ChEMBL
LigandPNGBDBM50444305(CHEMBL3093812)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of human neutrophil elastase using MeO-Suc-Ala-Ala-Pro-Val-AMC as substrate incubated for 30 mins prior to substrate addition measured for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyeloblastin(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50384111(CHEMBL2029556)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of proteinase 3 using N-MeOSuc-Ala-Ala-Pro-Val-p-nitroanilide as substrate after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target1-alkyl-2-acetylglycerophosphocholine esterase(Sus scrofa)
Univ. De Valencia

Curated by ChEMBL
LigandPNGBDBM50085497(2-(ethylamino)hexadecan-1-ol | 2-Ethylamino-hexade...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of secretory PLA2 activity in porcine pancreas using [3H]-oleate labelled membranes at a concentration of 10 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKallikrein-1(Homo sapiens (Human))
Universidade De Lisboa

Curated by ChEMBL
LigandPNGBDBM50084637(2,2-Dimethyl-propionic acid 4-[2-(carboxymethyl-ca...)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of human kallikrein using H-Pro-Phe-Arg-AMC acetate salt as substrate measured for 30 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin G(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50384108(CHEMBL2029554)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of cathepsin G using Suc-Ala-Ala-Pro-Phe-p-nitroanilide as substrate after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Universidade De Lisboa

Curated by ChEMBL
LigandPNGBDBM50444299(CHEMBL3093807)
Affinity DataIC50:  2.46E+3nMAssay Description:Inhibition of human neutrophil elastase using MeO-Suc-Ala-Ala-Pro-Val-AMC as substrate incubated for 30 mins prior to substrate addition measured for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Universidade De Lisboa

Curated by ChEMBL
LigandPNGBDBM50384112(CHEMBL2029557)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of human neutrophil elastase using chromogenic substrate (N-MeOSuc-Ala-Ala-Pro-Val-p-nitroanilide after 120 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Federal University Of Alfenas

Curated by ChEMBL
LigandPNGBDBM50590554(CHEMBL5183556)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibition of Electrophorus electricus AchE using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition by sp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target1-alkyl-2-acetylglycerophosphocholine esterase(Sus scrofa)
Univ. De Valencia

Curated by ChEMBL
LigandPNGBDBM50085496(CHEMBL89162 | N*1*,N*1*-Diethyl-hexadecane-1,2-dia...)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibition of secretory PLA2 activity in porcine pancreas using [3H]-oleate labelled membranes at a concentration of 10 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Univ. De Valencia

Curated by ChEMBL
LigandPNGBDBM50085497(2-(ethylamino)hexadecan-1-ol | 2-Ethylamino-hexade...)
Affinity DataIC50:  3.70E+3nMAssay Description:Inhibition of secretory PLA2 activity in human recombinant synovial enzyme using [3H]-oleate labelled membranes at a concentration of 10 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Universidade De Lisboa

Curated by ChEMBL
LigandPNGBDBM50444311(CHEMBL3093820)
Affinity DataIC50:  4.10E+3nMAssay Description:Inhibition of human neutrophil elastase using MeO-Suc-Ala-Ala-Pro-Val-AMC as substrate incubated for 30 mins prior to substrate addition measured for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Universidade De Lisboa

Curated by ChEMBL
LigandPNGBDBM50444304(CHEMBL3093813)
Affinity DataIC50:  4.60E+3nMAssay Description:Inhibition of human neutrophil elastase using MeO-Suc-Ala-Ala-Pro-Val-AMC as substrate incubated for 30 mins prior to substrate addition measured for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Equus caballus (Horse))
Federal University Of Alfenas

Curated by ChEMBL
LigandPNGBDBM8960((+/-)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimet...)
Affinity DataIC50:  4.70E+3nMAssay Description:Inhibition of equine serum BuChE using butyrylthiocholine as substrate preincubated for 10 mins followed by substrate addition by spectrophotometric ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMyeloblastin(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50384104(CHEMBL2029559)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of proteinase 3 using N-MeOSuc-Ala-Ala-Pro-Val-p-nitroanilide as substrate after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Universidade De Lisboa

Curated by ChEMBL
LigandPNGBDBM50444303(CHEMBL3093811)
Affinity DataIC50:  5.19E+3nMAssay Description:Inhibition of human neutrophil elastase using MeO-Suc-Ala-Ala-Pro-Val-AMC as substrate incubated for 30 mins prior to substrate addition measured for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Rattus norvegicus)
Universidade Federal Do Piau£

Curated by ChEMBL
LigandPNGBDBM50277167(CHEMBL4167962)
Affinity DataIC50:  5.51E+3nMAssay Description:Inhibition of Wistar rat plasma angiotensin 1-converting enzyme using H-hippuryl-His-Leu-OH as substrate after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Federal University Of Alfenas

Curated by ChEMBL
LigandPNGBDBM50590549(CHEMBL5175519)
Affinity DataIC50:  5.60E+3nMAssay Description:Inhibition of Electrophorus electricus AchE using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition by sp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Univ. De Valencia

Curated by ChEMBL
LigandPNGBDBM50085496(CHEMBL89162 | N*1*,N*1*-Diethyl-hexadecane-1,2-dia...)
Affinity DataIC50:  5.60E+3nMAssay Description:Inhibition of secretory PLA2 activity in human recombinant synovial enzyme using [3H]-oleate labelled membranes at a concentration of 10 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyeloblastin(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50444297(CHEMBL3093815)
Affinity DataIC50:  5.90E+3nMAssay Description:Inhibition of human proteinase 3 using N-MeOSuc-Ala-Ala-Pro-Val-p-nitroanilide as substrate measured for 30 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Federal University Of Alfenas

Curated by ChEMBL
LigandPNGBDBM50590558(CHEMBL5204385)
Affinity DataIC50:  5.90E+3nMAssay Description:Inhibition of Electrophorus electricus AchE using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition by sp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhospholipase A2(Homo sapiens (Human))
Univ. De Valencia

Curated by ChEMBL
LigandPNGBDBM50085497(2-(ethylamino)hexadecan-1-ol | 2-Ethylamino-hexade...)
Affinity DataIC50:  6.10E+3nMAssay Description:Inhibition of secretory PLA2 activity in Naja naja venom enzyme using [3H]-oleate labelled membranes at a concentration of 10 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2(Homo sapiens (Human))
Univ. De Valencia

Curated by ChEMBL
LigandPNGBDBM50085497(2-(ethylamino)hexadecan-1-ol | 2-Ethylamino-hexade...)
Affinity DataIC50:  6.20E+3nMAssay Description:Inhibition of secretory PLA2 activity in Naja naja venom enzyme using [3H]-oleate labelled membranes at a concentration of 10 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Federal University Of Alfenas

Curated by ChEMBL
LigandPNGBDBM50590553(CHEMBL5194995)
Affinity DataIC50:  8.20E+3nMAssay Description:Inhibition of Electrophorus electricus AchE using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition by sp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Universidade De Lisboa

Curated by ChEMBL
LigandPNGBDBM50444310(CHEMBL3093819)
Affinity DataIC50:  8.90E+3nMAssay Description:Inhibition of human neutrophil elastase using MeO-Suc-Ala-Ala-Pro-Val-AMC as substrate incubated for 30 mins prior to substrate addition measured for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Federal University Of Alfenas

Curated by ChEMBL
LigandPNGBDBM50590557(CHEMBL5185822)
Affinity DataIC50:  9.00E+3nMAssay Description:Inhibition of Electrophorus electricus AchE using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition by sp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhospholipase A2(Homo sapiens (Human))
Univ. De Valencia

Curated by ChEMBL
LigandPNGBDBM50085496(CHEMBL89162 | N*1*,N*1*-Diethyl-hexadecane-1,2-dia...)
Affinity DataIC50:  9.50E+3nMAssay Description:Inhibition of secretory PLA2 activity in bee venom enzyme using [3H]-oleate labelled membranes at a concentration of 10 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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