Found 208 with Last Name = 'am ende' and Initial = 'cw' TargetEnoyl-[acyl-carrier-protein] reductase [NADH](Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Stony Brook University
Curated by ChEMBL
Stony Brook University
Curated by ChEMBL
Affinity DataKi: 1nMAssay Description:Inhibition of Mycobacterium tuberculosis H37RV InhAMore data for this Ligand-Target Pair
TargetEnoyl-[acyl-carrier-protein] reductase [NADH](Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Stony Brook University
Curated by ChEMBL
Stony Brook University
Curated by ChEMBL
Affinity DataKi: 1nMAssay Description:Inhibition of Mycobacterium tuberculosis H37RV InhAMore data for this Ligand-Target Pair
TargetEnoyl-[acyl-carrier-protein] reductase [NADH](Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Stony Brook University
Curated by ChEMBL
Stony Brook University
Curated by ChEMBL
Affinity DataKi: 200nMAssay Description:Inhibition of Mycobacterium tuberculosis H37RV InhAMore data for this Ligand-Target Pair
3D Structure (crystal)
Affinity DataIC50: 0.160nMAssay Description:Inhibition of human recombinant FAAH using arachidonoyl-AMC as substrate preincubated for 30 mins followed by substrate addition measured after 60 mi...More data for this Ligand-Target Pair
Affinity DataIC50: 0.180nMAssay Description:Inhibition of human recombinant MAGL using 7-HCA as substrate preincubated for 30 mins followed by substrate addition measured after 60 mins by fluor...More data for this Ligand-Target Pair
Affinity DataIC50: 0.180nMAssay Description:Inhibition of human recombinant MAGL using 7-HCA as substrate preincubated for 30 mins followed by substrate addition measured after 60 mins by fluor...More data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human recombinant MAGL using 7-HCA as substrate preincubated for 30 mins followed by substrate addition measured after 60 mins by fluor...More data for this Ligand-Target Pair
Affinity DataIC50: 0.380nMAssay Description:Inhibition of human recombinant MAGL using 7-HCA as substrate preincubated for 30 mins followed by substrate addition measured after 60 mins by fluor...More data for this Ligand-Target Pair
Affinity DataIC50: 0.410nMAssay Description:Inhibition of human recombinant MAGL using 7-HCA as substrate preincubated for 30 mins followed by substrate addition measured after 60 mins by fluor...More data for this Ligand-Target Pair
Affinity DataIC50: 0.490nMAssay Description:Inhibition of human recombinant FAAH using arachidonoyl-AMC as substrate preincubated for 30 mins followed by substrate addition measured after 60 mi...More data for this Ligand-Target Pair
Affinity DataIC50: 0.560nMAssay Description:Inhibition of gamma-secretase (unknown origin) using Notch1 substrate assessed as Notch1-NICD productionMore data for this Ligand-Target Pair
Affinity DataIC50: 0.670nMAssay Description:Inhibition of human recombinant FAAH using arachidonoyl-AMC as substrate preincubated for 30 mins followed by substrate addition measured after 60 mi...More data for this Ligand-Target Pair
Affinity DataIC50: 0.700nMAssay Description:Inhibition of gamma-secretase (unknown origin) using APP substrate assessed as amyloid-beta40 productionMore data for this Ligand-Target Pair
Affinity DataIC50: 0.740nMAssay Description:Inhibition of human recombinant MAGL using 7-HCA as substrate preincubated for 30 mins followed by substrate addition measured after 60 mins by fluor...More data for this Ligand-Target Pair
Affinity DataIC50: 0.910nMAssay Description:Inhibition of gamma-secretase (unknown origin) using APP substrate assessed as amyloid-beta40 productionMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of gamma-secretase (unknown origin) using Notch1 substrate assessed as Notch1-NICD productionMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human recombinant FAAH using arachidonoyl-AMC as substrate preincubated for 30 mins followed by substrate addition measured after 60 mi...More data for this Ligand-Target Pair
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human recombinant MAGL using 7-HCA as substrate preincubated for 30 mins followed by substrate addition measured after 60 mins by fluor...More data for this Ligand-Target Pair
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human recombinant MAGL using 7-HCA as substrate preincubated for 30 mins followed by substrate addition measured after 60 mins by fluor...More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant MAGL using 7-HCA as substrate preincubated for 30 mins followed by substrate addition measured after 60 mins by fluor...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of MAGL in human brain vascular pericytes after 1 hr by TAMRA azide-based In-gel fluorescence methodMore data for this Ligand-Target Pair
Affinity DataIC50: 3.20nMAssay Description:Inhibition of human recombinant MAGL using 7-HCA as substrate preincubated for 30 mins followed by substrate addition measured after 60 mins by fluor...More data for this Ligand-Target Pair
Affinity DataIC50: 3.34nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein
Abeta(1-42) was determined using human WT-APP overexpressing CHO cells.
Cel...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of gamma-secretase in cell-free human HeLa membrane assessed as amyloid beta-42 production using APP as substrateMore data for this Ligand-Target Pair
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 4.5nMAssay Description:Inhibition of full length recombinant human PDE1B1 using 3',5'-[3H]cAMP as substrate after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.48nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein
Abeta(1-42) was determined using human WT-APP overexpressing CHO cells.
Cel...More data for this Ligand-Target Pair
Affinity DataIC50: 5.78nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein
Abeta(1-42) was determined using human WT-APP overexpressing CHO cells.
Cel...More data for this Ligand-Target Pair
TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in CHO cells overexpressing human wild type APP assessed as reduction of amyloid beta 42 lev...More data for this Ligand-Target Pair
TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Modulation of human gamma secretase overexpressed in CHO cells co-expressing wild type human APP assessed as inhibition of amyloid beta-42 production...More data for this Ligand-Target Pair
Affinity DataIC50: 7.84nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein
Abeta(1-42) was determined using human WT-APP overexpressing CHO cells.
Cel...More data for this Ligand-Target Pair
TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in CHO cells overexpressing human wild type APP assessed as reduction of amyloid beta 42 lev...More data for this Ligand-Target Pair
Affinity DataIC50: 8.35nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein
Abeta(1-42) was determined using human WT-APP overexpressing CHO cells.
Cel...More data for this Ligand-Target Pair
TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in CHO cells overexpressing human wild type APP assessed as reduction of amyloid beta 42 lev...More data for this Ligand-Target Pair
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 9.10nMAssay Description:Inhibition of full length recombinant human PDE1B1 using 3',5'-[3H]cAMP as substrate after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 9.10nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein
Abeta(1-42) was determined using human WT-APP overexpressing CHO cells.
Cel...More data for this Ligand-Target Pair
Affinity DataIC50: 9.40nMAssay Description:Inhibition of human recombinant FAAH using arachidonoyl-AMC as substrate preincubated for 30 mins followed by substrate addition measured after 60 mi...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein
Abeta(1-42) was determined using human WT-APP overexpressing CHO cells.
Cel...More data for this Ligand-Target Pair
Affinity DataIC50: 11nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein
Abeta(1-42) was determined using human WT-APP overexpressing CHO cells.
Cel...More data for this Ligand-Target Pair
TargetEnoyl-[acyl-carrier-protein] reductase [NADH](Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Stony Brook University
Curated by ChEMBL
Stony Brook University
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of 1 nM Mycobacterium tuberculosis H37RV InhAMore data for this Ligand-Target Pair
Affinity DataIC50: 11.1nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein
Abeta(1-42) was determined using human WT-APP overexpressing CHO cells.
Cel...More data for this Ligand-Target Pair
Affinity DataIC50: 11.4nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein
Abeta(1-42) was determined using human WT-APP overexpressing CHO cells.
Cel...More data for this Ligand-Target Pair
Affinity DataIC50: 13.3nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein
Abeta(1-42) was determined using human WT-APP overexpressing CHO cells.
Cel...More data for this Ligand-Target Pair
Affinity DataIC50: 14.3nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein
Abeta(1-42) was determined using human WT-APP overexpressing CHO cells.
Cel...More data for this Ligand-Target Pair
Affinity DataIC50: 14.5nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein
Abeta(1-42) was determined using human WT-APP overexpressing CHO cells.
Cel...More data for this Ligand-Target Pair
Affinity DataIC50: 15nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein
Abeta(1-42) was determined using human WT-APP overexpressing CHO cells.
Cel...More data for this Ligand-Target Pair
Affinity DataIC50: 15.7nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein
Abeta(1-42) was determined using human WT-APP overexpressing CHO cells.
Cel...More data for this Ligand-Target Pair
Affinity DataIC50: 16nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein
Abeta(1-42) was determined using human WT-APP overexpressing CHO cells.
Cel...More data for this Ligand-Target Pair
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of full length recombinant human PDE8B using 3',5'-[3H]cAMP as substrate after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Modulation of human gamma secretase overexpressed in CHO cells co-expressing wild type human APP assessed as inhibition of amyloid beta-42 production...More data for this Ligand-Target Pair
TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in CHO cells overexpressing human wild type APP assessed as reduction of amyloid beta 42 lev...More data for this Ligand-Target Pair
