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Found 95 with Last Name = 'andersen' and Initial = 'rj'
TargetPancreatic alpha-amylase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM163646(Montbretin A (MbA))
Affinity DataKi:  8.10nM ΔG°:  -47.0kJ/moleT: 2°CAssay Description:Inhibitor concentrations varied from 0.25 to 5 times the Ki value in 50 mM sodium phosphate, 100 mM sodium chloride buffer, pH 7.0, at 30 °C. 2-Chlor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPancreatic alpha-amylase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM163647(MbA-G (1))
Affinity DataKi:  9.10nM ΔG°:  -46.7kJ/moleT: 2°CAssay Description:Inhibitor concentrations varied from 0.25 to 5 times the Ki value in 50 mM sodium phosphate, 100 mM sodium chloride buffer, pH 7.0, at 30 °C. 2-Chlor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
University Of British Columbia

Curated by ChEMBL
LigandPNGBDBM50201794(CHEMBL3897445)
Affinity DataKi:  11nMAssay Description:Competitive inhibition of human recombinant cathepsin K using Z-FR-MCA fluorogenic substrate by Handerson plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPancreatic alpha-amylase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM163648(MbA-R (2))
Affinity DataKi:  21.3nM ΔG°:  -44.5kJ/moleT: 2°CAssay Description:Inhibitor concentrations varied from 0.25 to 5 times the Ki value in 50 mM sodium phosphate, 100 mM sodium chloride buffer, pH 7.0, at 30 °C. 2-Chlor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
University Of British Columbia

Curated by ChEMBL
LigandPNGBDBM50213272(CHEBI:6426 | Leupeptin)
Affinity DataKi:  24nMAssay Description:Competitive inhibition of recombinant human cathepsin K expressed in Pichia pastoris using Z-FR-MCA as substrate by Dixon plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
University Of British Columbia

Curated by ChEMBL
LigandPNGBDBM50201793(CHEMBL3899320)
Affinity DataKi:  41nMAssay Description:Competitive inhibition of human recombinant cathepsin K using Z-FR-MCA fluorogenic substrate by Handerson plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM21975((4S)-16'-(2-aminoethyl)-9'-hydroxy-1,3,6',6'-tetra...)
Affinity DataKi:  41nM ΔG°:  -43.9kJ/molepH: 6.5 T: 2°CAssay Description:The ability of the compounds prepared in this study to inhibit purified recombinant human IDO was evaluated with a steady state spectrophotometric as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM50324701(CHEMBL1221472 | Exiguamine A)
Affinity DataKi:  41nMAssay Description:Inhibition of human recombinant indoleamine-2,3-dioxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPancreatic alpha-amylase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM163649(MbA-RX (3))
Affinity DataKi:  42.4nM ΔG°:  -42.8kJ/moleT: 2°CAssay Description:Inhibitor concentrations varied from 0.25 to 5 times the Ki value in 50 mM sodium phosphate, 100 mM sodium chloride buffer, pH 7.0, at 30 °C. 2-Chlor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPancreatic alpha-amylase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM163650(MbA-GR (4))
Affinity DataKi:  79.3nM ΔG°:  -41.2kJ/moleT: 2°CAssay Description:Inhibitor concentrations varied from 0.25 to 5 times the Ki value in 50 mM sodium phosphate, 100 mM sodium chloride buffer, pH 7.0, at 30 °C. 2-Chlor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM50324700(CHEMBL1221412 | Exiguamine B)
Affinity DataKi:  80nMAssay Description:Inhibition of human recombinant indoleamine-2,3-dioxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM50324699(CHEMBL1221473 | Seco-exiguamine)
Affinity DataKi:  80nMAssay Description:Inhibition of human recombinant indoleamine-2,3-dioxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPancreatic alpha-amylase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM163651(MbA-GRX (5) | mini-MbA)
Affinity DataKi:  93.3nM ΔG°:  -40.8kJ/moleT: 2°CAssay Description:Inhibitor concentrations varied from 0.25 to 5 times the Ki value in 50 mM sodium phosphate, 100 mM sodium chloride buffer, pH 7.0, at 30 °C. 2-Chlor...More data for this Ligand-Target Pair
TargetCathepsin K(Homo sapiens (Human))
University Of British Columbia

Curated by ChEMBL
LigandPNGBDBM50201793(CHEMBL3899320)
Affinity DataKi:  105nMAssay Description:Competitive inhibition of human recombinant cathepsin K using Z-FR-MCA fluorogenic substrate by Dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
University Of British Columbia

Curated by ChEMBL
LigandPNGBDBM50201793(CHEMBL3899320)
Affinity DataKi:  105nMAssay Description:Competitive inhibition of human recombinant cathepsin K using Z-FR-MCA fluorogenic substrate by Dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM50241709(CHEMBL465020 | annulin B)
Affinity DataKi:  120nMAssay Description:Inhibition of human indoleamine 2,3-dioxygenase expressed in Escherichia coli by spectrophotometric activity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM50241707(CHEMBL518688 | annulin C | methyl 7-ethyl-8-hydrox...)
Affinity DataKi:  140nMAssay Description:Inhibition of human indoleamine 2,3-dioxygenase expressed in Escherichia coli by spectrophotometric activity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
University Of British Columbia

Curated by ChEMBL
LigandPNGBDBM50201795(CHEMBL3972383)
Affinity DataKi:  163nMAssay Description:Competitive inhibition of human recombinant cathepsin K using Z-FR-MCA fluorogenic substrate by Dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM21979(4,7-dihydro-1H-indole-4,7-dione | Indolequinone, 1...)
Affinity DataKi:  190nM ΔG°:  -39.9kJ/molepH: 6.5 T: 2°CAssay Description:The ability of the compounds prepared in this study to inhibit purified recombinant human IDO was evaluated with a steady state spectrophotometric as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM21982(3-(2-aminoethyl)-5-(3-methyl-2,5-dioxo-1-propylimi...)
Affinity DataKi:  200nM ΔG°:  -39.8kJ/molepH: 6.5 T: 2°CAssay Description:The ability of the compounds prepared in this study to inhibit purified recombinant human IDO was evaluated with a steady state spectrophotometric as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM21981(Tryptamine quinone, 21 | methyl 4-[3-(2-{[(benzylo...)
Affinity DataKi:  260nM ΔG°:  -39.1kJ/molepH: 6.5 T: 2°CAssay Description:The ability of the compounds prepared in this study to inhibit purified recombinant human IDO was evaluated with a steady state spectrophotometric as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM21984(Tryptamine quinone, 25 | methyl 4-{4,7-dioxo-3-[2-...)
Affinity DataKi:  260nM ΔG°:  -39.1kJ/molepH: 6.5 T: 2°CAssay Description:The ability of the compounds prepared in this study to inhibit purified recombinant human IDO was evaluated with a steady state spectrophotometric as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
University Of British Columbia

Curated by ChEMBL
LigandPNGBDBM50201792(CHEMBL3942776)
Affinity DataKi:  393nMAssay Description:Competitive inhibition of human recombinant cathepsin K using Z-FR-MCA fluorogenic substrate by Dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM21980(Indolequinone, 20 | methyl 4-(4,7-dioxo-4,7-dihydr...)
Affinity DataKi:  420nM ΔG°:  -37.9kJ/molepH: 6.5 T: 2°CAssay Description:The ability of the compounds prepared in this study to inhibit purified recombinant human IDO was evaluated with a steady state spectrophotometric as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM50241708(CHEMBL465019 | annulin A)
Affinity DataKi:  690nMAssay Description:Inhibition of human indoleamine 2,3-dioxygenase expressed in Escherichia coli by spectrophotometric activity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPancreatic alpha-amylase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM163652(MbA-C (6))
Affinity DataKi:  730nM ΔG°:  -35.6kJ/moleT: 2°CAssay Description:Inhibitor concentrations varied from 0.25 to 5 times the Ki value in 50 mM sodium phosphate, 100 mM sodium chloride buffer, pH 7.0, at 30 °C. 2-Chlor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM50241725(CHEMBL505049 | garveatin C)
Affinity DataKi:  1.20E+3nMAssay Description:Inhibition of human indoleamine 2,3-dioxygenase expressed in Escherichia coli by spectrophotometric activity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM50241710(2-hydroxygarveatin E | CHEMBL465021)
Affinity DataKi:  1.40E+3nMAssay Description:Inhibition of human indoleamine 2,3-dioxygenase expressed in Escherichia coli by spectrophotometric activity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM21976(Tryptamine quinone, 9 | benzyl N-[2-(4,7-dioxo-4,7...)
Affinity DataKi:  1.49E+3nM ΔG°:  -34.6kJ/molepH: 6.5 T: 2°CAssay Description:The ability of the compounds prepared in this study to inhibit purified recombinant human IDO was evaluated with a steady state spectrophotometric as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPancreatic alpha-amylase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM163653(MbA-CG (7))
Affinity DataKi:  2.24E+3nM ΔG°:  -32.8kJ/moleT: 2°CAssay Description:Inhibitor concentrations varied from 0.25 to 5 times the Ki value in 50 mM sodium phosphate, 100 mM sodium chloride buffer, pH 7.0, at 30 °C. 2-Chlor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM50241726(2-hydroxygarvin A | CHEMBL465623)
Affinity DataKi:  2.30E+3nMAssay Description:Inhibition of human indoleamine 2,3-dioxygenase expressed in Escherichia coli by spectrophotometric activity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM50241723(CHEMBL513118 | garveatin E)
Affinity DataKi:  3.10E+3nMAssay Description:Inhibition of human indoleamine 2,3-dioxygenase expressed in Escherichia coli by spectrophotometric activity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM50241724(CHEMBL505821 | garveatin A)
Affinity DataKi:  3.20E+3nMAssay Description:Inhibition of human indoleamine 2,3-dioxygenase expressed in Escherichia coli by spectrophotometric activity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM50241727((S)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic ac...)
Affinity DataKi:  6.60E+3nMAssay Description:Inhibition of human indoleamine 2,3-dioxygenase expressed in Escherichia coli by spectrophotometric activity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM21977(Tryptamine quinone, 13 | benzyl N-{2-[5-(1,3-dioxo...)
Affinity DataKi:  1.09E+4nM ΔG°:  -29.5kJ/molepH: 6.5 T: 2°CAssay Description:The ability of the compounds prepared in this study to inhibit purified recombinant human IDO was evaluated with a steady state spectrophotometric as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPancreatic alpha-amylase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM163656(3-O-(6-(4-(Caffeamidomethyl)-triazolyl)hexyl)querc...)
Affinity DataKi:  1.39E+4nM ΔG°:  -28.2kJ/moleT: 2°CAssay Description:Inhibitor concentrations varied from 0.25 to 5 times the Ki value in 50 mM sodium phosphate, 100 mM sodium chloride buffer, pH 7.0, at 30 °C. 2-Chlor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
University Of British Columbia

Curated by ChEMBL
LigandPNGBDBM50233350(CHEMBL4096643)
Affinity DataKi:  4.40E+4nMAssay Description:Competitive inhibition of recombinant human cathepsin K expressed in Pichia pastoris using Z-FR-MCA as substrate by Dixon plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPancreatic alpha-amylase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM163654(MbA-CR (8))
Affinity DataKi:  4.68E+4nM ΔG°:  -25.1kJ/moleT: 2°CAssay Description:Inhibitor concentrations varied from 0.25 to 5 times the Ki value in 50 mM sodium phosphate, 100 mM sodium chloride buffer, pH 7.0, at 30 °C. 2-Chlor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM21973(1-Methyltryptophan, 1 | 2-amino-3-(1-methyl-1H-ind...)
Affinity DataKi:  6.20E+4nM ΔG°:  -25.0kJ/molepH: 6.5 T: 2°CAssay Description:The ability of the compounds prepared in this study to inhibit purified recombinant human IDO was evaluated with a steady state spectrophotometric as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPancreatic alpha-amylase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM163655(MbA-CGR (9))
Affinity DataKi:  1.28E+5nM ΔG°:  -22.6kJ/moleT: 2°CAssay Description:Inhibitor concentrations varied from 0.25 to 5 times the Ki value in 50 mM sodium phosphate, 100 mM sodium chloride buffer, pH 7.0, at 30 °C. 2-Chlor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
University Of British Columbia

Curated by ChEMBL
LigandPNGBDBM15234((1R,3R,5S,9R,18S)-18-(methoxymethyl)-1,5-dimethyl-...)
Affinity DataIC50:  12nMAssay Description:Inhibition of human PI3Kalpha expressed in Sf9 cells by fluorescent polarization assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
University Of British Columbia

Curated by ChEMBL
LigandPNGBDBM50332741((4aS,11cS)-9,10-Dihydroxy-4,4,11c-trimethyl-1,2,3,...)
Affinity DataIC50:  66nMAssay Description:Inhibition of human PI3Kalpha expressed in Sf9 cells by fluorescent polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
University Of British Columbia

Curated by ChEMBL
LigandPNGBDBM50332731((4aS,7R,12cS)-10,11-Dihydroxy-4,4,7,12c-tetramethy...)
Affinity DataIC50:  100nMAssay Description:Inhibition of human PI3Kalpha expressed in Sf9 cells by fluorescent polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
University Of British Columbia

Curated by ChEMBL
LigandPNGBDBM12915(2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one |...)
Affinity DataIC50:  550nMAssay Description:Inhibition of human PI3Kalpha expressed in Sf9 cells by fluorescent polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
University Of British Columbia

Curated by ChEMBL
LigandPNGBDBM50332733((4'S,6R)-6'-bromo-2,2,4',6-tetramethyl-3',4'-dihyd...)
Affinity DataIC50:  700nMAssay Description:Inhibition of human PI3Kalpha expressed in Sf9 cells by fluorescent polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
University Of British Columbia

Curated by ChEMBL
LigandPNGBDBM50332743((4aS,11cS)-9,10-Dihydroxy-4,4,11c-trimethyl-1,2,3,...)
Affinity DataIC50:  700nMAssay Description:Inhibition of human PI3Kalpha expressed in Sf9 cells by fluorescent polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
University Of British Columbia

Curated by ChEMBL
LigandPNGBDBM50332742((4aS,11cS)-9-Hydroxy-10-methoxy-4,4,11c-trimethyl-...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of human PI3Kalpha expressed in Sf9 cells by fluorescent polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
University Of British Columbia

Curated by ChEMBL
LigandPNGBDBM50332731((4aS,7R,12cS)-10,11-Dihydroxy-4,4,7,12c-tetramethy...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of human PI3Kgamma expressed in Sf9 cells by fluorescent polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
University Of British Columbia

Curated by ChEMBL
LigandPNGBDBM50332743((4aS,11cS)-9,10-Dihydroxy-4,4,11c-trimethyl-1,2,3,...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of human PI3Kgamma expressed in Sf9 cells by fluorescent polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
University Of British Columbia

Curated by ChEMBL
LigandPNGBDBM50332739((4aS,11cS)-6a,10-Dihydroxy-4,4,11c-trimethyl-1,3,4...)
Affinity DataIC50:  1.65E+3nMAssay Description:Inhibition of human PI3Kalpha expressed in Sf9 cells by fluorescent polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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