Affinity DataKi: 0.0300nM ΔG°: -55.8kJ/moleT: 2°CAssay Description:For the membrane binding, NIH-3T3 cells were grown to 70% confluence in 15-cm2 dishes and transfected with 10 ug of receptor plasmid DNA using Polyfe...More data for this Ligand-Target Pair
Affinity DataKi: 0.0460nM ΔG°: -54.8kJ/moleT: 2°CAssay Description:For the membrane binding, NIH-3T3 cells were grown to 70% confluence in 15-cm2 dishes and transfected with 10 ug of receptor plasmid DNA using Polyfe...More data for this Ligand-Target Pair
Affinity DataKi: 0.0830nM ΔG°: -53.5kJ/moleT: 2°CAssay Description:For the membrane binding, NIH-3T3 cells were grown to 70% confluence in 15-cm2 dishes and transfected with 10 ug of receptor plasmid DNA using Polyfe...More data for this Ligand-Target Pair
Affinity DataKi: 0.440nM ΔG°: -49.6kJ/moleT: 2°CAssay Description:For the membrane binding, NIH-3T3 cells were grown to 70% confluence in 15-cm2 dishes and transfected with 10 ug of receptor plasmid DNA using Polyfe...More data for this Ligand-Target Pair
Affinity DataKi: 0.5nM ΔG°: -49.3kJ/moleT: 2°CAssay Description:For the membrane binding, NIH-3T3 cells were grown to 70% confluence in 15-cm2 dishes and transfected with 10 ug of receptor plasmid DNA using Polyfe...More data for this Ligand-Target Pair
Affinity DataKi: 0.550nM ΔG°: -49.1kJ/moleT: 2°CAssay Description:For the membrane binding, NIH-3T3 cells were grown to 70% confluence in 15-cm2 dishes and transfected with 10 ug of receptor plasmid DNA using Polyfe...More data for this Ligand-Target Pair
Affinity DataKi: 1.30nM ΔG°: -47.1kJ/moleT: 2°CAssay Description:For the membrane binding, NIH-3T3 cells were grown to 70% confluence in 15-cm2 dishes and transfected with 10 ug of receptor plasmid DNA using Polyfe...More data for this Ligand-Target Pair
Affinity DataKi: 1.30nM ΔG°: -47.1kJ/moleT: 2°CAssay Description:For the membrane binding, NIH-3T3 cells were grown to 70% confluence in 15-cm2 dishes and transfected with 10 ug of receptor plasmid DNA using Polyfe...More data for this Ligand-Target Pair
Affinity DataKi: 1.60nM ΔG°: -46.7kJ/moleT: 2°CAssay Description:For the membrane binding, NIH-3T3 cells were grown to 70% confluence in 15-cm2 dishes and transfected with 10 ug of receptor plasmid DNA using Polyfe...More data for this Ligand-Target Pair
Affinity DataKi: 3.80nM ΔG°: -44.7kJ/moleT: 2°CAssay Description:For the membrane binding, NIH-3T3 cells were grown to 70% confluence in 15-cm2 dishes and transfected with 10 ug of receptor plasmid DNA using Polyfe...More data for this Ligand-Target Pair
Affinity DataKi: 20nMAssay Description:Compound was evaluated for its binding against 5-hydroxytryptamine 2A receptorMore data for this Ligand-Target Pair
Affinity DataKi: 2.10E+4nMAssay Description:Inhibition of soybean glutamine synthetase by transferase assayMore data for this Ligand-Target Pair
Affinity DataKi: 4.00E+4nMAssay Description:Inhibition of Salmonella typhimurium glutamine synthetase by transferase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0690nMAssay Description:R-SAT assays were performed as described previously (Weiner et al., 2001), with the following modifications. In brief, NIH-3T3 cells were grown to 80...More data for this Ligand-Target Pair
Affinity DataIC50: 0.316nMAssay Description:Compound was evaluated for its inverse agonist activity against 5-hydroxytryptamine 2A receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:R-SAT assays were performed as described previously (Weiner et al., 2001), with the following modifications. In brief, NIH-3T3 cells were grown to 80...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Leo Pharma
Curated by ChEMBL
Leo Pharma
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant PDE4D after 1 hr by SPA in presence of radioactively labeled cAMPMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:R-SAT assays were performed as described previously (Weiner et al., 2001), with the following modifications. In brief, NIH-3T3 cells were grown to 80...More data for this Ligand-Target Pair
Affinity DataIC50: 1.90nMAssay Description:R-SAT assays were performed as described previously (Weiner et al., 2001), with the following modifications. In brief, NIH-3T3 cells were grown to 80...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Leo Pharma
Curated by ChEMBL
Leo Pharma
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant PDE4D after 1 hr by SPA in presence of radioactively labeled cAMPMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:R-SAT assays were performed as described previously (Weiner et al., 2001), with the following modifications. In brief, NIH-3T3 cells were grown to 80...More data for this Ligand-Target Pair
Affinity DataIC50: 4.5nMAssay Description:R-SAT assays were performed as described previously (Weiner et al., 2001), with the following modifications. In brief, NIH-3T3 cells were grown to 80...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Leo Pharma
Curated by ChEMBL
Leo Pharma
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant PDE4D after 1 hr by SPA in presence of radioactively labeled cAMPMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Leo Pharma
Curated by ChEMBL
Leo Pharma
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant PDE4D after 1 hr by SPA in presence of radioactively labeled cAMPMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Leo Pharma
Curated by ChEMBL
Leo Pharma
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of human recombinant PDE4D after 1 hr by SPA in presence of radioactively labeled cAMPMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Leo Pharma
Curated by ChEMBL
Leo Pharma
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of human recombinant PDE4D after 1 hr by SPA in presence of radioactively labeled cAMPMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Leo Pharma
Curated by ChEMBL
Leo Pharma
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of human recombinant PDE4D after 1 hr by SPA in presence of radioactively labeled cAMPMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Leo Pharma
Curated by ChEMBL
Leo Pharma
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of human recombinant PDE4D after 1 hr by SPA in presence of radioactively labeled cAMPMore data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:R-SAT assays were performed as described previously (Weiner et al., 2001), with the following modifications. In brief, NIH-3T3 cells were grown to 80...More data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Compound was evaluated for its inverse agonist activity against 5-hydroxytryptamine 2A receptorMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Leo Pharma
Curated by ChEMBL
Leo Pharma
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of human recombinant PDE4D after 1 hr by SPA in presence of radioactively labeled cAMPMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Leo Pharma
Curated by ChEMBL
Leo Pharma
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Inhibition of human recombinant PDE4D after 1 hr by SPA in presence of radioactively labeled cAMPMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Leo Pharma
Curated by ChEMBL
Leo Pharma
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Inhibition of human recombinant PDE4D after 1 hr by SPA in presence of radioactively labeled cAMPMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Leo Pharma
Curated by ChEMBL
Leo Pharma
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Inhibition of human recombinant PDE4D after 1 hr by SPA in presence of radioactively labeled cAMPMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Leo Pharma
Curated by ChEMBL
Leo Pharma
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of human recombinant PDE4D after 1 hr by SPA in presence of radioactively labeled cAMPMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Leo Pharma
Curated by ChEMBL
Leo Pharma
Curated by ChEMBL
Affinity DataIC50: 45nMAssay Description:Inhibition of human recombinant PDE4D after 1 hr by SPA in presence of radioactively labeled cAMPMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Leo Pharma
Curated by ChEMBL
Leo Pharma
Curated by ChEMBL
Affinity DataIC50: 61nMAssay Description:Inhibition of human recombinant PDE4D after 1 hr by SPA in presence of radioactively labeled cAMPMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Leo Pharma
Curated by ChEMBL
Leo Pharma
Curated by ChEMBL
Affinity DataIC50: 63nMAssay Description:In vitro inhibition of KDRMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Leo Pharma
Curated by ChEMBL
Leo Pharma
Curated by ChEMBL
Affinity DataIC50: 63nMAssay Description:Inhibition of human recombinant PDE4D after 1 hr by SPA in presence of radioactively labeled cAMPMore data for this Ligand-Target Pair
Affinity DataIC50: 79nMAssay Description:Compound was evaluated for its inverse agonist activity against 5-hydroxytryptamine 2A receptorMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Leo Pharma
Curated by ChEMBL
Leo Pharma
Curated by ChEMBL
Affinity DataIC50: 81nMAssay Description:Inhibition of human recombinant PDE4D after 1 hr by SPA in presence of radioactively labeled cAMPMore data for this Ligand-Target Pair
Affinity DataIC50: 82nMAssay Description:Inhibition of mouse AChEMore data for this Ligand-Target Pair
Affinity DataIC50: 91nMAssay Description:R-SAT assays were performed as described previously (Weiner et al., 2001), with the following modifications. In brief, NIH-3T3 cells were grown to 80...More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:R-SAT assays were performed as described previously (Weiner et al., 2001), with the following modifications. In brief, NIH-3T3 cells were grown to 80...More data for this Ligand-Target Pair