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Found 1054 with Last Name = 'andrews' and Initial = 'md'
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50161646((1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-ben...)
Affinity DataKi:  15nMAssay Description:Displacement of [125I]DOI from human recombinant 5HT2C receptor expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50342539(2-(3-chlorobenzyl)-6,7,8,9-tetrahydro-5H-pyrimido[...)
Affinity DataKi:  84nMAssay Description:Displacement of [3H]meselurgine from human 5HT2C receptor expressed in Swiss mouse 3T3 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50301772((R)-6-(2-methylpiperazin-1-yl)-2-(2-(2-(trifluorom...)
Affinity DataKi:  89nMAssay Description:Displacement of [3H]meselurgine from human recombinant 5HT2C receptor expressed in Swiss mouse 3T3 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50342538(2-benzyl-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azep...)
Affinity DataKi:  160nMAssay Description:Displacement of [3H]meselurgine from human 5HT2C receptor expressed in Swiss mouse 3T3 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50161646((1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-ben...)
Affinity DataKi:  167nMAssay Description:Displacement of [3H]meselurgine from human 5HT2C receptor expressed in Swiss mouse 3T3 cells by scintillation proximity assayMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50342547(2-(3-methylbenzyl)-6,7,8,9-tetrahydro-5H-pyrimido[...)
Affinity DataKi:  244nMAssay Description:Displacement of [3H]meselurgine from human 5HT2C receptor expressed in Swiss mouse 3T3 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50342548(2-(2-methylbenzyl)-6,7,8,9-tetrahydro-5H-pyrimido[...)
Affinity DataKi:  305nMAssay Description:Displacement of [3H]meselurgine from human 5HT2C receptor expressed in Swiss mouse 3T3 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50342544(2-(3-(trifluoromethyl)benzyl)-6,7,8,9-tetrahydro-5...)
Affinity DataKi:  308nMAssay Description:Displacement of [3H]meselurgine from human 5HT2C receptor expressed in Swiss mouse 3T3 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50302145((R)-2-(2-(2-chlorophenoxy)ethyl)-6-(2-methylpipera...)
Affinity DataKi:  325nMAssay Description:Displacement of [3H]meselurgine from human recombinant 5HT2C receptor expressed in Swiss mouse 3T3 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50302160(6-(piperazin-1-yl)-2-(2-(2-(trifluoromethyl)phenox...)
Affinity DataKi:  424nMAssay Description:Displacement of [3H]meselurgine from human recombinant 5HT2C receptor expressed in Swiss mouse 3T3 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50342549(2-(4-fluorobenzyl)-6,7,8,9-tetrahydro-5H-pyrimido[...)
Affinity DataKi:  470nMAssay Description:Displacement of [3H]meselurgine from human 5HT2C receptor expressed in Swiss mouse 3T3 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50302151((S)-2-(1-(2-chlorophenoxy)propan-2-yl)-6-(piperazi...)
Affinity DataKi:  728nMAssay Description:Displacement of [3H]meselurgine from human recombinant 5HT2C receptor expressed in Swiss mouse 3T3 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50302141(2-(2-(2-chlorophenoxy)ethyl)-6-(piperazin-1-yl)pyr...)
Affinity DataKi:  1.60E+3nMAssay Description:Displacement of [3H]meselurgine from human recombinant 5HT2C receptor expressed in Swiss mouse 3T3 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50342545(2-(2-chlorobenzyl)-6,7,8,9-tetrahydro-5H-pyrimido[...)
Affinity DataKi:  1.85E+3nMAssay Description:Displacement of [3H]meselurgine from human 5HT2C receptor expressed in Swiss mouse 3T3 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50089252(CHEMBL3577889)
Affinity DataKi: >9.18E+3nMAssay Description:Inhibition of dofetilide binding to human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50089251(CHEMBL3576881)
Affinity DataKi: >9.18E+3nMAssay Description:Inhibition of dofetilide binding to human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50089248(CHEMBL3577881)
Affinity DataKi: >9.18E+3nMAssay Description:Inhibition of dofetilide binding to human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50301770((R)-3-methyl-6-(2-methylpiperazin-1-yl)-2-((2-(tri...)
Affinity DataKi: >1.30E+4nMAssay Description:Binding affinity to human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50089253(CHEMBL3577900)
Affinity DataKi: >1.52E+4nMAssay Description:Inhibition of dofetilide binding to human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50089245(CHEMBL3577885)
Affinity DataKi: >1.59E+4nMAssay Description:Inhibition of dofetilide binding to human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM30547(US8846698, 583)
Affinity DataIC50:  0.681nMAssay Description:Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM30449(US8846698, 580)
Affinity DataIC50:  0.825nMAssay Description:Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM134792(US8846698, 256)
Affinity DataIC50:  1.09nMAssay Description:Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM135100(US8846698, 526)
Affinity DataIC50:  1.51nMAssay Description:Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM135053(US8846698, 538)
Affinity DataIC50:  1.51nMAssay Description:Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM135077(US8846698, 564)
Affinity DataIC50:  1.57nMAssay Description:Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM135051(US8846698, 536)
Affinity DataIC50:  1.57nMAssay Description:Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM135089(US8846698, 577)
Affinity DataIC50:  1.90nMAssay Description:Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50294264(CHEMBL562244 | rac-3-((biphenyl-2-yloxy)(piperidin...)
Affinity DataIC50:  2nMAssay Description:Inhibition of [3H]NA uptake at human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM135043(US8846698, 528)
Affinity DataIC50:  2.25nMAssay Description:Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM135064(US8846698, 551)
Affinity DataIC50:  2.78nMAssay Description:Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM186567(US9163021, 235)
Affinity DataIC50:  2.87nMAssay Description:Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM186437(US9163021, 95)
Affinity DataIC50:  2.92nMAssay Description:Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM135083(US8846698, 571)
Affinity DataIC50:  2.92nMAssay Description:Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM135058(US8846698, 545)
Affinity DataIC50:  2.95nMAssay Description:Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50294273(CHEMBL562854 | rac-3-((2,3-dimethylphenoxy)(piperi...)
Affinity DataIC50:  3nMAssay Description:Inhibition of [3H]5-HT uptake at human 5HTT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50294287(3-((2,3-dichlorophenoxy)((S)-piperidin-3-yl)methyl...)
Affinity DataIC50:  3nMAssay Description:Inhibition of [3H]NA uptake at human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50294266(CHEMBL550696 | rac-3-((3-chlorophenoxy)(piperidin-...)
Affinity DataIC50:  3nMAssay Description:Inhibition of [3H]5-HT uptake at human 5HTT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50294272(CHEMBL563987 | rac-3-((2,3-difluorophenoxy)(piperi...)
Affinity DataIC50:  3nMAssay Description:Inhibition of [3H]5-HT uptake at human 5HTT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50294287(3-((2,3-dichlorophenoxy)((S)-piperidin-3-yl)methyl...)
Affinity DataIC50:  3nMAssay Description:Inhibition of [3H]NA uptake at human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM134750(US8846698, 213 | US8846698, 215)
Affinity DataIC50:  3.03nMAssay Description:Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM135087(US8846698, 575)
Affinity DataIC50:  3.09nMAssay Description:Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM186376(US9163021, 33)
Affinity DataIC50:  3.11nMAssay Description:Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM135076(US8846698, 563)
Affinity DataIC50:  3.11nMAssay Description:Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM135069(US8846698, 556)
Affinity DataIC50:  3.16nMAssay Description:Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM30532(US8846698, 581)
Affinity DataIC50:  3.21nMAssay Description:Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM135062(US8846698, 549)
Affinity DataIC50:  3.22nMAssay Description:Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM134787(US8846698, 250)
Affinity DataIC50:  3.48nMAssay Description:Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM134603(US8846698, 66)
Affinity DataIC50:  3.55nMAssay Description:Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM134763(US8846698, 226)
Affinity DataIC50:  3.61nMAssay Description:Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...More data for this Ligand-Target Pair
In DepthDetails US Patent
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