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Found 278 with Last Name = 'auerbach' and Initial = 'b'
TargetNPC1-like intracellular cholesterol transporter 1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50240720((2S,3S,4S,5R,6S)-6-(4-((2S,3R)-1-(4-fluorophenyl)-...)
Affinity DataKi:  180nMAssay Description:Displacement of [3H]ezetimibe-glucuronide from NPC1L1 in Sprague-Dawley rat brush border membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNPC1-like intracellular cholesterol transporter 1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50371521(EZETIMIBE)
Affinity DataKi:  200nMAssay Description:Displacement of [3H]ezetimibe-glucuronide from NPC1L1 in Sprague-Dawley rat brush border membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNPC1-like intracellular cholesterol transporter 1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50371519(CHEMBL271655)
Affinity DataKi:  1.40E+3nMAssay Description:Displacement of [3H]ezetimibe-glucuronide from NPC1L1 in Sprague-Dawley rat brush border membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNPC1-like intracellular cholesterol transporter 1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50371538(CHEMBL271634)
Affinity DataKi:  2.30E+3nMAssay Description:Displacement of [3H]ezetimibe-glucuronide from NPC1L1 in Sprague-Dawley rat brush border membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNPC1-like intracellular cholesterol transporter 1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50371523(CHEMBL258358)
Affinity DataKi:  3.60E+3nMAssay Description:Displacement of [3H]ezetimibe-glucuronide from NPC1L1 in Sprague-Dawley rat brush border membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNPC1-like intracellular cholesterol transporter 1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50371520(CHEMBL257848)
Affinity DataKi:  4.80E+3nMAssay Description:Displacement of [3H]ezetimibe-glucuronide from NPC1L1 in Sprague-Dawley rat brush border membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNPC1-like intracellular cholesterol transporter 1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50371537(CHEMBL402421)
Affinity DataKi:  5.70E+3nMAssay Description:Displacement of [3H]ezetimibe-glucuronide from NPC1L1 in Sprague-Dawley rat brush border membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNPC1-like intracellular cholesterol transporter 1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50371542(CHEMBL439420)
Affinity DataKi:  8.70E+3nMAssay Description:Displacement of [3H]ezetimibe-glucuronide from NPC1L1 in Sprague-Dawley rat brush border membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNPC1-like intracellular cholesterol transporter 1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50371528(CHEMBL257850)
Affinity DataKi:  9.20E+3nMAssay Description:Displacement of [3H]ezetimibe-glucuronide from NPC1L1 in Sprague-Dawley rat brush border membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNPC1-like intracellular cholesterol transporter 1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50371533(CHEMBL258061)
Affinity DataKi:  9.90E+3nMAssay Description:Displacement of [3H]ezetimibe-glucuronide from NPC1L1 in Sprague-Dawley rat brush border membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNPC1-like intracellular cholesterol transporter 1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50371517(CHEMBL256248)
Affinity DataKi:  1.10E+4nMAssay Description:Displacement of [3H]ezetimibe-glucuronide from NPC1L1 in Sprague-Dawley rat brush border membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNPC1-like intracellular cholesterol transporter 1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50371524(CHEMBL271635)
Affinity DataKi:  1.10E+4nMAssay Description:Displacement of [3H]ezetimibe-glucuronide from NPC1L1 in Sprague-Dawley rat brush border membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNPC1-like intracellular cholesterol transporter 1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50371530(CHEMBL258143)
Affinity DataKi:  1.20E+4nMAssay Description:Displacement of [3H]ezetimibe-glucuronide from NPC1L1 in Sprague-Dawley rat brush border membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNPC1-like intracellular cholesterol transporter 1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50371527(CHEMBL271865)
Affinity DataKi:  1.40E+4nMAssay Description:Displacement of [3H]ezetimibe-glucuronide from NPC1L1 in Sprague-Dawley rat brush border membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNPC1-like intracellular cholesterol transporter 1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50371543(CHEMBL272091)
Affinity DataKi:  1.50E+4nMAssay Description:Displacement of [3H]ezetimibe-glucuronide from NPC1L1 in Sprague-Dawley rat brush border membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNPC1-like intracellular cholesterol transporter 1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50371534(CHEMBL257474)
Affinity DataKi:  1.60E+4nMAssay Description:Displacement of [3H]ezetimibe-glucuronide from NPC1L1 in Sprague-Dawley rat brush border membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNPC1-like intracellular cholesterol transporter 1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50371535(CHEMBL257095)
Affinity DataKi:  1.80E+4nMAssay Description:Displacement of [3H]ezetimibe-glucuronide from NPC1L1 in Sprague-Dawley rat brush border membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNPC1-like intracellular cholesterol transporter 1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50371541(CHEMBL404200)
Affinity DataKi:  1.90E+4nMAssay Description:Displacement of [3H]ezetimibe-glucuronide from NPC1L1 in Sprague-Dawley rat brush border membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNPC1-like intracellular cholesterol transporter 1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50371536(CHEMBL430216)
Affinity DataKi:  1.90E+4nMAssay Description:Displacement of [3H]ezetimibe-glucuronide from NPC1L1 in Sprague-Dawley rat brush border membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNPC1-like intracellular cholesterol transporter 1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50371529(CHEMBL271856)
Affinity DataKi:  2.80E+4nMAssay Description:Displacement of [3H]ezetimibe-glucuronide from NPC1L1 in Sprague-Dawley rat brush border membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNPC1-like intracellular cholesterol transporter 1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50371546(CHEMBL429751)
Affinity DataKi:  2.80E+4nMAssay Description:Displacement of [3H]ezetimibe-glucuronide from NPC1L1 in Sprague-Dawley rat brush border membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNPC1-like intracellular cholesterol transporter 1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50371526(CHEMBL270155)
Affinity DataKi:  3.00E+4nMAssay Description:Displacement of [3H]ezetimibe-glucuronide from NPC1L1 in Sprague-Dawley rat brush border membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNPC1-like intracellular cholesterol transporter 1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50371516(CHEMBL442973)
Affinity DataKi:  3.30E+4nMAssay Description:Displacement of [3H]ezetimibe-glucuronide from NPC1L1 in Sprague-Dawley rat brush border membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNPC1-like intracellular cholesterol transporter 1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50371545(CHEMBL403245)
Affinity DataKi:  4.90E+4nMAssay Description:Displacement of [3H]ezetimibe-glucuronide from NPC1L1 in Sprague-Dawley rat brush border membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNPC1-like intracellular cholesterol transporter 1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50371547(CHEMBL436647)
Affinity DataKi: >5.00E+4nMAssay Description:Displacement of [3H]ezetimibe-glucuronide from NPC1L1 in Sprague-Dawley rat brush border membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNPC1-like intracellular cholesterol transporter 1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50371544(CHEMBL272303)
Affinity DataKi: >5.00E+4nMAssay Description:Displacement of [3H]ezetimibe-glucuronide from NPC1L1 in Sprague-Dawley rat brush border membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNPC1-like intracellular cholesterol transporter 1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50371540(CHEMBL255524)
Affinity DataKi: >5.00E+4nMAssay Description:Displacement of [3H]ezetimibe-glucuronide from NPC1L1 in Sprague-Dawley rat brush border membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNPC1-like intracellular cholesterol transporter 1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50371539(CHEMBL256849)
Affinity DataKi: >5.00E+4nMAssay Description:Displacement of [3H]ezetimibe-glucuronide from NPC1L1 in Sprague-Dawley rat brush border membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNPC1-like intracellular cholesterol transporter 1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50371531(CHEMBL255984)
Affinity DataKi: >5.00E+4nMAssay Description:Displacement of [3H]ezetimibe-glucuronide from NPC1L1 in Sprague-Dawley rat brush border membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNPC1-like intracellular cholesterol transporter 1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50371525(CHEMBL257076)
Affinity DataKi: >5.00E+4nMAssay Description:Displacement of [3H]ezetimibe-glucuronide from NPC1L1 in Sprague-Dawley rat brush border membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNPC1-like intracellular cholesterol transporter 1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50371522(CHEMBL257849)
Affinity DataKi: >5.00E+4nMAssay Description:Displacement of [3H]ezetimibe-glucuronide from NPC1L1 in Sprague-Dawley rat brush border membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNPC1-like intracellular cholesterol transporter 1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50371518(CHEMBL402308)
Affinity DataKi: >5.00E+4nMAssay Description:Displacement of [3H]ezetimibe-glucuronide from NPC1L1 in Sprague-Dawley rat brush border membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNPC1-like intracellular cholesterol transporter 1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50371532(CHEMBL445414)
Affinity DataKi: >5.00E+4nMAssay Description:Displacement of [3H]ezetimibe-glucuronide from NPC1L1 in Sprague-Dawley rat brush border membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50215692(CHEMBL400874 | sodium (3R,5R)-7-(5-((4-cyanobenzyl...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50215676(CHEMBL228955 | sodium (3R,5R)-7-(3-(4-fluorophenyl...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of HMGCoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50215693(CHEMBL437774 | sodium (3R,5R)-7-(5-((4-carboxyphen...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50215689(CHEMBL250317 | sodium (3R,5R)-7-(5-((4-carbamoylph...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50215688(CHEMBL399773 | sodium (3R,5R)-7-(5-((3-(dimethylca...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50215700(CHEMBL400973 | sodium (3R,5R)-7-(3-(4-fluorophenyl...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50215704(CHEMBL398551 | sodium (3R,5R)-7-(5-(((1,5-dimethyl...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50215707(CHEMBL250749 | sodium (3R,5R)-7-(5-((4-(methoxymet...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50215699(CHEMBL400747 | sodium (3R,5R)-7-(3,4-bis(4-fluorop...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50215690(CHEMBL399313 | sodium (3R,5R)-7-(5-(benzylcarbamoy...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50215708(CHEMBL249724 | sodium (3R,5R)-7-(5-((4-methoxybenz...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50215684(CHEMBL398240 | sodium (3R,5R)-7-(3-(4-fluorophenyl...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Pfizer

LigandPNGBDBM18382(Alkyl substituted pyrrole compound, 29f | disodium...)
Affinity DataIC50:  0.850nMpH: 7.2 T: 2°CAssay Description:Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Pfizer

LigandPNGBDBM18425((3R,5R)-7-[1-(4-fluorophenyl)-3-{[(4-methylphenyl)...)
Affinity DataIC50:  1nMAssay Description:Inhibition of HMG-CoA reductase in Sprague-Dawley rat liver microsomes using using [14C]HMG-CoA as substrate preincubated for 0.5 hrs before substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Pfizer

LigandPNGBDBM50231035(CHEMBL401950 | sodium; (3R,5R)-7-[3-(3-carbamoylme...)
Affinity DataIC50:  1nMAssay Description:Inhibition of rat microsomal HMGCoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Pfizer

LigandPNGBDBM50346288(CHEMBL1782560 | sodium(3R,5R)-7-(5-cyclopropyl-4-(...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of HMG-CoA reductase in Sprague-Dawley rat liver microsomes using using [14C]HMG-CoA as substrate preincubated for 0.5 hrs before substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Pfizer

LigandPNGBDBM50346289(CHEMBL1782561 | sodium(3R,5R)-7-(5-cyclopropyl-4-(...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of HMG-CoA reductase in Sprague-Dawley rat liver microsomes using using [14C]HMG-CoA as substrate preincubated for 0.5 hrs before substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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