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Found 392 with Last Name = 'bargiotti' and Initial = 'a'
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
Istituto Di Ricerche Chimiche E Biochimiche G. Ronzoni

Curated by ChEMBL
LigandPNGBDBM50308730(4-((2S,5S,11S,14R)-14-benzyl-11-(carboxymethyl)-5-...)
Affinity DataIC50:  0.170nMAssay Description:Displacement of [125I]echistatin from integrin alphaVbeta5 receptor after 3 hrs by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM7167(3-(4-sulfamoylphenyl)-3,4,10,11-tetraazatricyclo[7...)
Affinity DataIC50:  0.300nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
Istituto Di Ricerche Chimiche E Biochimiche G. Ronzoni

Curated by ChEMBL
LigandPNGBDBM50308728(1-(4-((5S,11S,14R)-14-benzyl-11-(carboxymethyl)-5-...)
Affinity DataIC50:  0.350nMAssay Description:Displacement of [125I]echistatin from integrin alphaVbeta5 receptor after 3 hrs by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
Istituto Di Ricerche Chimiche E Biochimiche G. Ronzoni

Curated by ChEMBL
LigandPNGBDBM50308726(2-[(2S,5R,8S,11S)-5-benzyl-11-(3-carbamimidamidopr...)
Affinity DataIC50:  0.370nMAssay Description:Displacement of [125I]echistatin from integrin alphaVbeta5 receptor after 3 hrs by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Istituto Di Ricerche Chimiche E Biochimiche G. Ronzoni

Curated by ChEMBL
LigandPNGBDBM50308726(2-[(2S,5R,8S,11S)-5-benzyl-11-(3-carbamimidamidopr...)
Affinity DataIC50:  0.590nMAssay Description:Displacement of [125I]echistatin from integrin alphaVbeta3 receptor after 3 hrs by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
Istituto Di Ricerche Chimiche E Biochimiche G. Ronzoni

Curated by ChEMBL
LigandPNGBDBM50308727(2-((2S,5R,8S,11S)-5-benzyl-11-(3-guanidinopropyl)-...)
Affinity DataIC50:  0.650nMAssay Description:Displacement of [125I]echistatin from integrin alphaVbeta5 receptor after 3 hrs by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM7177(3-(4-methanesulfonylphenyl)-3,4,10,11-tetraazatric...)
Affinity DataIC50:  1nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM27380((7S)-2-(2-aminopyrimidin-4-yl)-7-(2-fluoroethyl)-1...)
Affinity DataIC50:  2nMAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM7173(3-[4-(butylsulfamoyl)phenyl]-3,4,10,11-tetraazatri...)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM27362(7-(2-fluoroethyl)-2-(pyridin-4-yl)-1H,4H,5H,6H,7H-...)
Affinity DataIC50:  2nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50329419(5-(2-amino-5-bromopyrimidin-4-yl)-2-p-tolyl-1H-pyr...)
Affinity DataIC50:  2nMAssay Description:Inhibition of Cdc7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM27391(5,13,17-triazatetracyclo[8.7.0.0^{2,7}.0^{11,16}]h...)
Affinity DataIC50:  2nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM27371(2-(2-aminopyrimidin-4-yl)-7,7-dimethyl-1H,4H,5H,6H...)
Affinity DataIC50:  2nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM7214(3-(2,2,2-trifluoroethyl)-3,4,10,11-tetraazatricycl...)
Affinity DataIC50:  2nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM7169(3-[4-(methylsulfamoyl)phenyl]-3,4,10,11-tetraazatr...)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM27359(7-ethyl-2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrrolo[3,...)
Affinity DataIC50:  2nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM27370(2-(2-aminopyrimidin-4-yl)-7-(2-fluoroethyl)-1H,4H,...)
Affinity DataIC50:  3nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM27348(6-(2-methylpropyl)-2-(pyridin-4-yl)-1H,4H,5H,6H,7H...)
Affinity DataIC50:  3nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM27363(7,7-dimethyl-2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrro...)
Affinity DataIC50:  3nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM27361(7-cyclobutyl-2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrro...)
Affinity DataIC50:  3nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM27413(2-(2-aminopyrimidin-4-yl)-1-(2-fluoroethyl)-1H,4H,...)
Affinity DataIC50:  3nMAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Istituto Di Ricerche Chimiche E Biochimiche G. Ronzoni

Curated by ChEMBL
LigandPNGBDBM50308727(2-((2S,5R,8S,11S)-5-benzyl-11-(3-guanidinopropyl)-...)
Affinity DataIC50:  3.80nMAssay Description:Displacement of [125I]echistatin from integrin alphaVbeta3 receptor after 3 hrs by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM27412(2-(2-aminopyrimidin-4-yl)-1-(cyclopropylmethyl)-1H...)
Affinity DataIC50:  4nMAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM27390(2-(2-amino-5-bromopyrimidin-4-yl)-1H,4H,5H,6H,7H-p...)
Affinity DataIC50:  4nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM27377(2-(2-aminopyrimidin-4-yl)-7-(2-hydroxyethyl)-1H,4H...)
Affinity DataIC50:  4nMAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM27368(2-(2-aminopyrimidin-4-yl)-7-(propan-2-yl)-1H,4H,5H...)
Affinity DataIC50:  4nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50279340((Z)-2-[(Furan-2-ylmethyl)-amino]-5-[1-(1H-pyrrolo[...)
Affinity DataIC50:  4nMAssay Description:Inhibition of Cdc7 (unknown origin)-mediated phosphorylation of Mcm2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM7166(3-(4-sulfamoylphenyl)-3,4,10,11-tetraazatricyclo[7...)
Affinity DataIC50:  4nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Istituto Di Ricerche Chimiche E Biochimiche G. Ronzoni

Curated by ChEMBL
LigandPNGBDBM50308728(1-(4-((5S,11S,14R)-14-benzyl-11-(carboxymethyl)-5-...)
Affinity DataIC50:  4nMAssay Description:Displacement of [125I]echistatin from integrin alphaVbeta3 receptor after 3 hrs by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM27372(2-(2-aminopyrimidin-4-yl)-7,7-diethyl-1H,4H,5H,6H,...)
Affinity DataIC50:  5nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM7195(3-(4-cyanophenyl)-3,4,10,11-tetraazatricyclo[7.3.0...)
Affinity DataIC50:  5nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM27406(2-(2-aminopyrimidin-4-yl)-1-(2,2,2-trifluoroethyl)...)
Affinity DataIC50:  5nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM27369(2-(2-aminopyrimidin-4-yl)-7-cyclobutyl-1H,4H,5H,6H...)
Affinity DataIC50:  5nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM27379((7R)-2-(2-aminopyrimidin-4-yl)-7-(2-fluoroethyl)-1...)
Affinity DataIC50:  5nMAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM27367(2-(2-aminopyrimidin-4-yl)-7-ethyl-1H,4H,5H,6H,7H-p...)
Affinity DataIC50:  5nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50329420(5-(2-amino-5-chloropyrimidin-4-yl)-2-p-tolyl-1H-py...)
Affinity DataIC50:  5nMAssay Description:Inhibition of Cdc7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM27347(6-cyclopropyl-2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrr...)
Affinity DataIC50:  5nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
Istituto Di Ricerche Chimiche E Biochimiche G. Ronzoni

Curated by ChEMBL
LigandPNGBDBM50308729(4-(4-((2S,5S,11S,14R)-14-benzyl-11-(carboxymethyl)...)
Affinity DataIC50:  5.10nMAssay Description:Displacement of [125I]echistatin from integrin alphaVbeta5 receptor after 3 hrs by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM27366(2-(2-aminopyrimidin-4-yl)-7-methyl-1H,4H,5H,6H,7H-...)
Affinity DataIC50:  6nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM27346(6-(propan-2-yl)-2-(pyridin-4-yl)-1H,4H,5H,6H,7H-py...)
Affinity DataIC50:  6nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Istituto Di Ricerche Chimiche E Biochimiche G. Ronzoni

Curated by ChEMBL
LigandPNGBDBM50308722(2-[(2S,5R,8S,11S)-5-benzyl-11-(3-carbamimidamidopr...)
Affinity DataIC50:  6nMAssay Description:Displacement of [125I]echistatin from integrin alphaVbeta3 receptor after 3 hrs by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM27364(7,7-diethyl-2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrrol...)
Affinity DataIC50:  6nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
Istituto Di Ricerche Chimiche E Biochimiche G. Ronzoni

Curated by ChEMBL
LigandPNGBDBM50308724(2-[(2S,5R,8S,11S)-5-benzyl-11-(3-carbamimidamidopr...)
Affinity DataIC50:  6.5nMAssay Description:Displacement of [125I]echistatin from integrin alphaVbeta5 receptor after 3 hrs by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM27375(2-(2-aminopyrimidin-4-yl)-7-[2-(benzyloxy)ethyl]-1...)
Affinity DataIC50:  7nMAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM27421(2-[2-(phenylamino)pyrimidin-4-yl]-1H,4H,5H,6H,7H-p...)
Affinity DataIC50:  7nMAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM27351(2-(2-aminopyrimidin-4-yl)-1H,4H,5H,6H,7H-pyrrolo[3...)
Affinity DataIC50:  7nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM27351(2-(2-aminopyrimidin-4-yl)-1H,4H,5H,6H,7H-pyrrolo[3...)
Affinity DataIC50:  7nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Istituto Di Ricerche Chimiche E Biochimiche G. Ronzoni

Curated by ChEMBL
LigandPNGBDBM50308725(2-[(2S,5R,8S,11S)-5-benzyl-11-(3-carbamimidamidopr...)
Affinity DataIC50:  7.30nMAssay Description:Displacement of [125I]echistatin from integrin alphaVbeta3 receptor after 3 hrs by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM7206(3-(pyridin-2-yl)-3,4,10,11-tetraazatricyclo[7.3.0....)
Affinity DataIC50:  8nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM7187(3-(4-chlorophenyl)-3,4,10,11-tetraazatricyclo[7.3....)
Affinity DataIC50:  8nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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