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Found 1767 with Last Name = 'burke' and Initial = 'tr'
TargetGlutamate receptor ionotropic, NMDA 2C(Rattus norvegicus (Rat))
National Institute Of Diabetes, Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM83449(1-(1-phenylcyclohexyl)piperidine;hydrochloride | M...)
Affinity DataKi:  91nMAssay Description:Binding affinity to sigma site of Phencyclidine receptor by displacement of [3H]-(+)-SKF- 10,047More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50071330(CHEMBL2369450 | c(S-CH2-Ac-Asp-Ala-Asp-Glu-FOMT-Le...)
Affinity DataKi:  170nMAssay Description:Compound was evaluated for the binding affinity against protein-tyrosine phosphatase 1B (PTP1B)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50103243(4-{2-[2-(2-Acetylamino-3-carboxy-propionylamino)-p...)
Affinity DataKi:  200nMAssay Description:Inhibitory activity against human Protein-tyrosinephosphatase 1B (PTP1B)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2C(Rattus norvegicus (Rat))
National Institute Of Diabetes, Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM83449(1-(1-phenylcyclohexyl)piperidine;hydrochloride | M...)
Affinity DataKi:  530nMAssay Description:Binding affinity to sigma site of Phencyclidine receptor by displacement of [3H]-(+)-SKF- 10,047More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2C(Rattus norvegicus (Rat))
National Institute Of Diabetes, Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50405724(CHEMBL1169565)
Affinity DataKi:  630nMAssay Description:Binding affinity of compound against Phencyclidine receptor by displacement of [3H]TCPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2C(Rattus norvegicus (Rat))
National Institute Of Diabetes, Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50405723(CHEMBL1169564)
Affinity DataKi:  680nMAssay Description:Binding affinity of compound against Phencyclidine receptor by displacement of [3H]TCPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2C(Rattus norvegicus (Rat))
National Institute Of Diabetes, Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50405723(CHEMBL1169564)
Affinity DataKi:  2.60E+3nMAssay Description:Binding affinity to sigma site of Phencyclidine receptor by displacement of [3H]-(+)-SKF- 10,047More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor susceptibility gene 101 protein(Homo sapiens (Human))
Nci-Frederick

Curated by ChEMBL
LigandPNGBDBM50362892(CHEMBL1946564)
Affinity DataKi:  2.60E+3nMAssay Description:Displacement of FITC-conjugated (S)-4-((S)-1-acetylpyrrolidine-2-carboxamido)-5-((2S,4R)-2-((2S,3R)-1-((S)-1-((S)-2-((S)-2-((S)-1-((S)-1-amino-4-carb...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor susceptibility gene 101 protein(Homo sapiens (Human))
Nci-Frederick

Curated by ChEMBL
LigandPNGBDBM50362891(CHEMBL1946260)
Affinity DataKi:  2.70E+3nMAssay Description:Displacement of FITC-conjugated (S)-4-((S)-1-acetylpyrrolidine-2-carboxamido)-5-((2S,4R)-2-((2S,3R)-1-((S)-1-((S)-2-((S)-2-((S)-1-((S)-1-amino-4-carb...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2C(Rattus norvegicus (Rat))
National Institute Of Diabetes, Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50405724(CHEMBL1169565)
Affinity DataKi:  3.20E+3nMAssay Description:Binding affinity to sigma site of Phencyclidine receptor by displacement of [3H]-(+)-SKF- 10,047More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50103235(5-[2-(2-{2-[2-(2-Acetylamino-3-carboxy-propionylam...)
Affinity DataKi:  3.60E+3nMAssay Description:Inhibitory activity against human Protein-tyrosinephosphatase 1B (PTP1B)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor susceptibility gene 101 protein(Homo sapiens (Human))
Nci-Frederick

Curated by ChEMBL
LigandPNGBDBM50362890(CHEMBL1946259)
Affinity DataKi:  5.40E+3nMAssay Description:Displacement of FITC-conjugated (S)-4-((S)-1-acetylpyrrolidine-2-carboxamido)-5-((2S,4R)-2-((2S,3R)-1-((S)-1-((S)-2-((S)-2-((S)-1-((S)-1-amino-4-carb...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor susceptibility gene 101 protein(Homo sapiens (Human))
Nci-Frederick

Curated by ChEMBL
LigandPNGBDBM50362889(CHEMBL1946129)
Affinity DataKi:  8.70E+3nMAssay Description:Displacement of FITC-conjugated (S)-4-((S)-1-acetylpyrrolidine-2-carboxamido)-5-((2S,4R)-2-((2S,3R)-1-((S)-1-((S)-2-((S)-2-((S)-1-((S)-1-amino-4-carb...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50103240(4-Carbamoyl-4-{[6-(difluoro-phosphono-methyl)-naph...)
Affinity DataKi:  1.20E+4nMAssay Description:Inhibitory activity against human Protein-tyrosinephosphatase 1B (PTP1B)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50050961(2-{4-[(S)-2-((S)-2-{(S)-2-[(S)-2-((S)-2-Acetylamin...)
Affinity DataKi:  1.30E+4nMAssay Description:Compound was evaluated for the binding affinity against protein-tyrosine phosphatase 1B (PTP1B)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50132237(CHEMBL320852 | [Difluoro-(6-methanesulfonylaminoca...)
Affinity DataKi:  1.70E+4nMAssay Description:Binding affinity of the compound towards recombinant human Protein-tyrosine phosphatase 1B was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50103227(6-(Difluoro-phosphono-methyl)-naphthalene-2-carbox...)
Affinity DataKi:  2.20E+4nMAssay Description:Inhibitory activity against human Protein-tyrosinephosphatase 1B (PTP1B)More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50103227(6-(Difluoro-phosphono-methyl)-naphthalene-2-carbox...)
Affinity DataKi:  2.20E+4nMAssay Description:Binding affinity of the compound towards recombinant human Protein-tyrosine phosphatase 1B was determinedMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50131098(2-(4-{2-((S)-1-(S)-Carbamoyl-3-methyl-butylcarbamo...)
Affinity DataKi:  2.90E+4nMAssay Description:Inhibitory potency against human Protein-tyrosine phosphatase 1B expressed in E. coli BL21 (DE3) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50075312((Difluoro-naphthalen-2-yl-methyl)-phosphonic acid ...)
Affinity DataKi:  1.79E+5nMAssay Description:Binding affinity of the compound towards recombinant human Protein-tyrosine phosphatase 1B was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50103238(3-Carboxymethoxy-naphthalene-2,7-dicarboxylic acid...)
Affinity DataKi:  2.50E+5nMAssay Description:Inhibitory activity against human Protein-tyrosinephosphatase 1B (PTP1B)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50103234(2-Carboxymethoxy-naphthalene-1,6-dicarboxylic acid...)
Affinity DataKi:  9.00E+5nMAssay Description:Inhibitory activity against human Protein-tyrosinephosphatase 1B (PTP1B)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50103231(CHEMBL98615 | Naphthalene-2,7-dicarboxylic acid)
Affinity DataKi: >3.20E+6nMAssay Description:Inhibitory activity against human Protein-tyrosinephosphatase 1B (PTP1B)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50103242(CHEMBL316894 | Naphthalene trisulfonate (NTS) | na...)
Affinity DataKi: >4.00E+6nMAssay Description:Inhibitory activity against human Protein-tyrosinephosphatase 1B (PTP1B)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50021347(CHEMBL12391 | N-(3-Methyl-1-phenethyl-piperidin-4-...)
Affinity DataIC50:  1.30nMAssay Description:In vivo binding affinity to opioid receptor preparations from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50021347(CHEMBL12391 | N-(3-Methyl-1-phenethyl-piperidin-4-...)
Affinity DataIC50:  1.30nMAssay Description:In vivo binding affinity to opioid receptor preparations from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth factor receptor-bound protein 2(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50139763(CHEMBL306657 | [(E)-(9S,10S,14S,18S)-18-Carbamoylm...)
Affinity DataIC50:  1.40nMAssay Description:In vitro Growth factor receptor bound protein 2-binding affinity of the compound was determined in in surface plasmon resonance (SPR) methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth factor receptor-bound protein 2(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50139763(CHEMBL306657 | [(E)-(9S,10S,14S,18S)-18-Carbamoylm...)
Affinity DataIC50:  1.40nMAssay Description:In vitro Growth factor receptor bound protein 2-binding affinity of the compound was determined in in surface plasmon resonance (SPR) methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth factor receptor-bound protein 2(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50085869(CHEMBL367037 | N-[1-(1-{2-Carbamoyl-1-[3-(5-methyl...)
Affinity DataIC50:  2nMAssay Description:Inhibition of Growth factor receptor bound protein 2 binding by ELISA assay methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth factor receptor-bound protein 2(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50139763(CHEMBL306657 | [(E)-(9S,10S,14S,18S)-18-Carbamoylm...)
Affinity DataIC50:  2nMAssay Description:In vitro binding affinity in extracellular ELISA-based assay for Grb2 SH2 domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth factor receptor-bound protein 2(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50122796(CHEMBL84798 | [18-Carbamoylmethyl-14-(2,3-dihydro-...)
Affinity DataIC50:  2nMAssay Description:Inhibition against Growth factor receptor bound protein 2 binding using ELISA techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth factor receptor-bound protein 2(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50168312(2-{4-[(16R,20S)-18-((S)-Carbamoylmethyl)-9-carboxy...)
Affinity DataIC50:  3.30nMAssay Description:Inhibitory concentration against growth factor receptor bound protein 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth factor receptor-bound protein 2(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50073909(CHEMBL72036 | {4-[(S)-2-Acetylamino-2-(1-{(S)-2-ca...)
Affinity DataIC50:  4nMAssay Description:Inhibition of Growth factor receptor bound protein 2 binding by ELISA assay methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50403016(CHEMBL2207845)
Affinity DataIC50:  4nMAssay Description:Inhibition of 5CF-GPMQSpTPLNG-NH2 binding to Plk1 C-terminal polo-box domain (unknown origin) preincubated for 30 mins followed by probe addition mea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth factor receptor-bound protein 2(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50143944(2-[4-((E)-(9S,10S,14S,18S)-18-Carbamoylmethyl-9-ca...)
Affinity DataIC50:  4.30nMAssay Description:In vitro Growth factor receptor bound protein 2-binding affinity of the compound was determined in ELISA methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD(P)H dehydrogenase [quinone] 1(Homo sapiens (Human))
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50055714(3-(4,7-dihydroxy-2-oxo-2H-3-chromenylmethyl)-4,7-d...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant NQO1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50467110(CHEMBL4278200)
Affinity DataIC50:  5nMAssay Description:Inhibition of 5CF-GPMQSpTPLNG-NH2 binding to Plk1 C-terminal polo-box domain (unknown origin) preincubated for 30 mins followed by probe addition mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50403016(CHEMBL2207845)
Affinity DataIC50:  5nMAssay Description:Inhibition of 5CF-GPMQSpTPLNG-NH2 binding to myc-tagged human Plk1 PBD expressed in HEK-293T cells incubated for 1 hr by fluorescence polarization as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD(P)H dehydrogenase [quinone] 1(Homo sapiens (Human))
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM35525(3,3''''-methylenebis(4-hydroxy-coumarin | 3,3''''-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant NQO1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
MMDB

TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50260122(CHEMBL4092848)
Affinity DataIC50:  5.5nMAssay Description:Inhibition of 5CF-GPMQSpTPLNG-NH2 binding to myc-tagged human Plk1 PBD expressed in HEK-293T cells incubated for 1 hr by fluorescence polarization as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50260121(CHEMBL4068949)
Affinity DataIC50:  5.5nMAssay Description:Inhibition of Biotin-Ahx-PMQS(pT)PLN-NH2 binding to myc-tagged full-length human Plk1 expressed in HEK-293T cells incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50403016(CHEMBL2207845)
Affinity DataIC50:  5.60nMAssay Description:Competitive binding affinity to GFP-HA-fused PLK1 polo box domain expressed in HEK293A cells using biotinylated p-T38 peptide as substrate after 1 hr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50467111(CHEMBL4281659)
Affinity DataIC50:  6nMAssay Description:Inhibition of 5CF-GPMQSpTPLNG-NH2 binding to Plk1 C-terminal polo-box domain (unknown origin) preincubated for 30 mins followed by probe addition mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGrowth factor receptor-bound protein 2(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50168318(CHEMBL424823 | [(15R,20S)-18-Carbamoylmethyl-10-[4...)
Affinity DataIC50:  6.30nMAssay Description:Inhibitory concentration against growth factor receptor bound protein 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50194933(CHEMBL3956625)
Affinity DataIC50:  6.60nMAssay Description:Inhibition of 5CF-GPMQSpTPLNG-NH2 binding to myc-tagged human Plk1 PBD expressed in HEK-293T cells incubated for 1 hr by fluorescence polarization as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth factor receptor-bound protein 2(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50075017(CHEMBL332862 | Phosphoric acid mono-[4-((R)-2-acet...)
Affinity DataIC50:  7nMAssay Description:Inhibitory concentration of the compound against Growth factor receptor bound protein 2 in MDA-MB-453 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50467112(CHEMBL4287557)
Affinity DataIC50:  8nMAssay Description:Inhibition of 5CF-GPMQSpTPLNG-NH2 binding to Plk1 C-terminal polo-box domain (unknown origin) preincubated for 30 mins followed by probe addition mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
TBA

Curated by ChEMBL
LigandPNGBDBM50027791(6,11-Dimethyl-3-phenethyl-1,2,3,4,5,6-hexahydro-2,...)
Affinity DataIC50:  8nMAssay Description:Ability to induce 50% of maximal effect in mouse vas deferens expressing Opioid receptor delta 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth factor receptor-bound protein 2(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50122792(CHEMBL312875 | [3-Carbamoylmethyl-14-(2,3-dihydro-...)
Affinity DataIC50:  8nMAssay Description:Inhibition against Growth factor receptor bound protein 2 binding using ELISA techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth factor receptor-bound protein 2(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50085874(2-{4-[(S)-2-(1-{(S)-2-Carbamoyl-1-[3-(5-methyl-ind...)
Affinity DataIC50:  8nMAssay Description:Inhibition of Growth factor receptor bound protein 2 binding by ELISA assay methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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