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Found 360 with Last Name = 'deegan' and Initial = 't'
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50353767(CHEMBL1829430)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50353767(CHEMBL1829430)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50353788(CHEMBL1829433)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50353788(CHEMBL1829433)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50288378(CHEMBL4162065)
Affinity DataIC50: <3nMAssay Description:GRAC: human IMPase 1 inhibitorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50288372(CHEMBL4173429)
Affinity DataIC50: <3nMAssay Description:Inhibition of cytoplasmic recombinant human GST-tagged JAK1 (886 to 1154 residues) expressed in insect cells using FITC-C6-KKHTDDGYMPMSPGVA-NH as sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50353799(CHEMBL1829424)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50353767(CHEMBL1829430)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50353799(CHEMBL1829424)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50288437(CHEMBL4165758)
Affinity DataIC50: <3nMAssay Description:GRAC: human PDE2A selective inhibitorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50288438(CHEMBL4173676)
Affinity DataIC50: <3nMAssay Description:Inhibition of cytoplasmic recombinant human GST-tagged JAK1 (886 to 1154 residues) expressed in insect cells using FITC-C6-KKHTDDGYMPMSPGVA-NH as sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50288511(CHEMBL4171692)
Affinity DataIC50: <3nMAssay Description:Inhibition of cytoplasmic recombinant human GST-tagged JAK1 (886 to 1154 residues) expressed in insect cells using FITC-C6-KKHTDDGYMPMSPGVA-NH as sub...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50288439(CHEMBL4163817)
Affinity DataIC50: <3nMAssay Description:Inhibition of cytoplasmic recombinant human GST-tagged JAK1 (886 to 1154 residues) expressed in insect cells using FITC-C6-KKHTDDGYMPMSPGVA-NH as sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50288443(CHEMBL4166989)
Affinity DataIC50: <3nMAssay Description:Inhibition of cytoplasmic recombinant human GST-tagged JAK1 (886 to 1154 residues) expressed in insect cells using FITC-C6-KKHTDDGYMPMSPGVA-NH as sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50244783(2-chloro-5-[(3,5-dimethylbenzoyl)amino]-N-1,3-thia...)
Affinity DataIC50:  3nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50244781(2-Chloro-N-thiazol-5-yl-5-(3-trifluoromethyl-benzo...)
Affinity DataIC50:  3nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50244726(2-chloro-5-[(3,4-dichlorobenzoyl)amino]-N-pyridin-...)
Affinity DataIC50:  3nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50244725(2-chloro-5-[(3,5-dichlorobenzoyl)amino]-N-pyridin-...)
Affinity DataIC50:  3nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50244843(2-Chloro-5-(3-chloro-benzoylamino)-N-(2-methyl-thi...)
Affinity DataIC50:  4nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50244844(5-[(3,5-dimethylbenzoyl)amino]-2-methyl-N-(2-methy...)
Affinity DataIC50:  4nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50288437(CHEMBL4165758)
Affinity DataIC50:  4nMAssay Description:GRAC: human H3 selective antagonistMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50135125(CHEMBL3747305)
Affinity DataIC50:  4.90nMAssay Description:Inhibition of N-terminal GST-fused human recombinant JAK1 (866 to 1154 residues) expressed in insect cells using FITC-C6-KKHTDDGYMPMSPGVA-NH2 as subs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50353820(CHEMBL1829432)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50288442(CHEMBL4173835)
Affinity DataIC50:  5nMAssay Description:Inhibition of cytoplasmic recombinant human GST-tagged JAK1 (886 to 1154 residues) expressed in insect cells using FITC-C6-KKHTDDGYMPMSPGVA-NH as sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50244782(2-Chloro-5-(3-chloro-benzoylamino)-N-thiazol-5-yl-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50244724(2-chloro-5-[(3,4-dimethylbenzoyl)amino]-N-pyridin-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50256750(CHEMBL475817 | N-(6-amino-5-chloropyridin-3-yl)-2-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of p38alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50256750(CHEMBL475817 | N-(6-amino-5-chloropyridin-3-yl)-2-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50244845(2-chloro-5-[(3,5-dimethylbenzoyl)amino]-N-(2-methy...)
Affinity DataIC50:  6nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50288376(CHEMBL4177188)
Affinity DataIC50:  6nMAssay Description:GRAC: human p38a selective inhibitorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50244846(2-chloro-5-{[3-fluoro-5-(trifluoromethyl)benzoyl]a...)
Affinity DataIC50:  7nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50244842(2-Chloro-N-(2-methyl-thiazol-5-yl)-5-(3-trifluorom...)
Affinity DataIC50:  7nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50244780(5-(3-Chloro-benzoylamino)-2-methyl-N-(2-methyl-thi...)
Affinity DataIC50:  7nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50353799(CHEMBL1829424)
Affinity DataIC50:  8nMAssay Description:Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50244723(2-chloro-5-[(3,5-dimethylbenzoyl)amino]-N-pyridin-...)
Affinity DataIC50:  8nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50135127(CHEMBL3746766)
Affinity DataIC50:  9nMAssay Description:Inhibition of N-terminal GST-fused human recombinant JAK1 (866 to 1154 residues) expressed in insect cells using FITC-C6-KKHTDDGYMPMSPGVA-NH2 as subs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50244674(2-Chloro-5-(3-methoxy-benzoylamino)-N-pyridin-3-yl...)
Affinity DataIC50:  9nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50353821(CHEMBL1829246)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50288512(CHEMBL4163122)
Affinity DataIC50:  10nMAssay Description:Inhibition of cytoplasmic recombinant human GST-tagged JAK1 (886 to 1154 residues) expressed in insect cells using FITC-C6-KKHTDDGYMPMSPGVA-NH as sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50244632(2-Chloro-5-(3-methyl-benzoylamino)-N-pyridin-3-yl-...)
Affinity DataIC50:  10nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50244672(2-Chloro-5-(3-chloro-benzoylamino)-N-pyridin-3-yl-...)
Affinity DataIC50:  10nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50244784(2-Methyl-N-(2-methyl-thiazol-5-yl)-5-(3-trifluorom...)
Affinity DataIC50:  10nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50244895(2-chloro-5-[(3-chloro-5-fluorobenzoyl)amino]-N-(2-...)
Affinity DataIC50:  11nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50244582(CHEMBL507803 | N-(2-methyl-5-(3-(trifluoromethyl)b...)
Affinity DataIC50:  11nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)
Affinity DataIC50:  12nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50288441(CHEMBL4166565)
Affinity DataIC50:  12nMAssay Description:Inhibition of cytoplasmic recombinant human GST-tagged JAK1 (886 to 1154 residues) expressed in insect cells using FITC-C6-KKHTDDGYMPMSPGVA-NH as sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50353823(CHEMBL1829422)
Affinity DataIC50:  13nMAssay Description:Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50244896(2-Chloro-N-(2-isopropyl-thiazol-5-yl)-5-(3-trifluo...)
Affinity DataIC50:  13nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50288374(CHEMBL4169982)
Affinity DataIC50:  13nMAssay Description:Inhibition of cytoplasmic recombinant human GST-tagged JAK1 (886 to 1154 residues) expressed in insect cells using FITC-C6-KKHTDDGYMPMSPGVA-NH as sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50244673(5-(3-Bromo-benzoylamino)-2-chloro-N-pyridin-3-yl-b...)
Affinity DataIC50:  14nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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