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Found 232 with Last Name = 'ellsworth' and Initial = 'kp'
TargetCoagulation factor IX(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50125977(CHEMBL3627897)
Affinity DataKi:  9.10nMAssay Description:Inhibition of human factor 9a using CH3SO2-DCHG-Gly-Arg-AFC.AcOH as substrate preinubated for 30 mins followed by substrate addition measured after 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor IX(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50151405(CHEMBL3775211 | US10189819, Example 79)
Affinity DataKi:  11nMAssay Description:Inhibition of human factor 9a using CH3SO2-DCHG-Gly-Arg-AFC.AcOH as substrate preinubated for 30 mins followed by substrate addition measured after 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50125977(CHEMBL3627897)
Affinity DataKi:  2.80E+3nMAssay Description:Inhibition of human factor 10a using n-Acetyl-KPR-AFC as substrate preinubated for 30 mins followed by substrate addition measured after 1 hr by fluo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMalonyl-CoA decarboxylase, mitochondrial(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328246(3-(4-carbamoyl-1-(5-(1,1,1,3,3,3-hexafluoro-2-hydr...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of human MCDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMalonyl-CoA decarboxylase, mitochondrial(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328247(4-(3-carboxyphenyl)-1-(5-(1,1,1,3,3,3-hexafluoro-2...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of human MCDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMalonyl-CoA decarboxylase, mitochondrial(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328235(3-(1-(5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of human MCDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMalonyl-CoA decarboxylase, mitochondrial(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328248(1-(5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of human MCDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50135558(4-{3-Fluoro-2-[(4-nitro-pyridine-2-carbonyl)-amino...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against HLGP(human liver glycogen phosphorylase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50135554(4-{3-[(4-Nitro-pyridine-2-carbonyl)-amino]-naphtha...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against HLGP(human liver glycogen phosphorylase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMalonyl-CoA decarboxylase, mitochondrial(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328241(1-(5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human MCDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMalonyl-CoA decarboxylase, mitochondrial(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328222(3-(4-(5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of human MCDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMalonyl-CoA decarboxylase, mitochondrial(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328244(4-(4-fluorophenyl)-1-(5-(1,1,1,3,3,3-hexafluoro-2-...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of human MCDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMalonyl-CoA decarboxylase, mitochondrial(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328226(2-(2-(4-(3-(1H-tetrazol-5-yl)phenyl)piperazin-1-yl...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of human MCDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMalonyl-CoA decarboxylase, mitochondrial(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328245(1,1,1,3,3,3-hexafluoro-2-(2-(4-(2-fluorophenyl)-4-...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of human MCDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMalonyl-CoA decarboxylase, mitochondrial(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328234(2-(1-(5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of human MCDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMalonyl-CoA decarboxylase, mitochondrial(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328237(3-(1-(5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of human MCDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor IX(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50151406(CHEMBL3774670)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of human factor 9a using CH3SO2-DCHG-Gly-Arg-AFC.AcOH as substrate preinubated for 30 mins followed by substrate addition measured after 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50135565(4-{3-[(4-Methoxy-pyridine-2-carbonyl)-amino]-napht...)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity against HLGP(human liver glycogen phosphorylase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50135553(4-{3-[(4-Chloro-pyridine-2-carbonyl)-amino]-naphth...)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity against HLGP(human liver glycogen phosphorylase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50133440(1-(4-Chloro-benzyl)-4-(2-chloro-phenyl)-6-methyl-1...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibitory activity against human liver glycogen phosphorylase a (HLGPa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMalonyl-CoA decarboxylase, mitochondrial(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328225(3-(4-(5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of human MCDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMalonyl-CoA decarboxylase, mitochondrial(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328227(3-(4-(5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of human MCDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMalonyl-CoA decarboxylase, mitochondrial(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328221(2-(2-(4-(4-aminophenyl)piperazin-1-yl)thiazol-5-yl...)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of human MCDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50135562(4-{2-[(4-Nitro-pyridine-2-carbonyl)-amino]-phenoxy...)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity against HLGP(human liver glycogen phosphorylase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, muscle form(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50135554(4-{3-[(4-Nitro-pyridine-2-carbonyl)-amino]-naphtha...)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity against HMGP(human muscle glycogen phosphorylase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMalonyl-CoA decarboxylase, mitochondrial(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328238(3-(1-(5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-...)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of human MCDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMalonyl-CoA decarboxylase, mitochondrial(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328220(2-(2-(4-(3-aminophenyl)piperazin-1-yl)thiazol-5-yl...)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of human MCDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMalonyl-CoA decarboxylase, mitochondrial(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328249(1-(5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)...)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of human MCDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50133438(4-(2-Chloro-phenyl)-1-(3,4-dimethoxy-benzyl)-6-met...)
Affinity DataIC50:  4nMAssay Description:In vitro inhibitory activity against human liver glycogen phosphorylase a (HLGPa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50135557(4-{3-[(4-Ethyl-pyridine-2-carbonyl)-amino]-naphtha...)
Affinity DataIC50:  4nMAssay Description:Inhibitory activity against HLGP(human liver glycogen phosphorylase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMalonyl-CoA decarboxylase, mitochondrial(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328236(4-(1-(5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human MCDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMalonyl-CoA decarboxylase, mitochondrial(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328239(1-(5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)...)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of human MCDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMalonyl-CoA decarboxylase, mitochondrial(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328243(1-(5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)...)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of human MCDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMalonyl-CoA decarboxylase, mitochondrial(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328242(1-(5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)...)
Affinity DataIC50:  4.90nMAssay Description:Inhibition of human MCDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50133442(4-(2-Chloro-phenyl)-6-methyl-1-(3-nitro-benzyl)-1,...)
Affinity DataIC50:  5nMAssay Description:In vitro inhibitory activity against human liver glycogen phosphorylase a (HLGPa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMalonyl-CoA decarboxylase, mitochondrial(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328223(2-(4-(5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-...)
Affinity DataIC50:  5.10nMAssay Description:Inhibition of human MCDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMalonyl-CoA decarboxylase, mitochondrial(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328254(1,1,1,3,3,3-hexafluoro-2-(2-(4-(trifluoromethyl)ph...)
Affinity DataIC50:  5.70nMAssay Description:Inhibition of human MCDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, muscle form(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50133440(1-(4-Chloro-benzyl)-4-(2-chloro-phenyl)-6-methyl-1...)
Affinity DataIC50:  6nMAssay Description:In vitro inhibitory activity against human muscle glycogen phosphorylase a (HMGPa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMalonyl-CoA decarboxylase, mitochondrial(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328250(4-(2-aminothiazol-4-yl)-7-(5-(1,1,1,3,3,3-hexafluo...)
Affinity DataIC50:  6.70nMAssay Description:Inhibition of human MCDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50133443(4-(2-Chloro-phenyl)-1-ethyl-5-isobutylcarbamoyl-6-...)
Affinity DataIC50:  7.88nMAssay Description:In vitro inhibitory activity against human liver glycogen phosphorylase a (HLGPa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50133431(1-(3-Chloro-benzyl)-4-(2-chloro-phenyl)-6-methyl-1...)
Affinity DataIC50:  8nMAssay Description:In vitro inhibitory activity against human liver glycogen phosphorylase a (HLGPa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMalonyl-CoA decarboxylase, mitochondrial(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328212(1,1,1,3,3,3-hexafluoro-2-(2-(4-(4-fluorophenyl)pip...)
Affinity DataIC50:  8.10nMAssay Description:Inhibition of human MCDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, muscle form(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50133443(4-(2-Chloro-phenyl)-1-ethyl-5-isobutylcarbamoyl-6-...)
Affinity DataIC50:  8.28nMAssay Description:In vitro inhibitory activity against human muscle glycogen phosphorylase a (HMGPa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMalonyl-CoA decarboxylase, mitochondrial(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328211(1,1,1,3,3,3-hexafluoro-2-(2-(4-(3-fluorophenyl)pip...)
Affinity DataIC50:  8.70nMAssay Description:Inhibition of human MCDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMalonyl-CoA decarboxylase, mitochondrial(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328217(1,1,1,3,3,3-hexafluoro-2-(2-(4-(4-nitrophenyl)pipe...)
Affinity DataIC50:  8.90nMAssay Description:Inhibition of human MCDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, muscle form(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50135558(4-{3-Fluoro-2-[(4-nitro-pyridine-2-carbonyl)-amino...)
Affinity DataIC50:  9nMAssay Description:Inhibitory activity against HMGP(human muscle glycogen phosphorylase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Mus musculus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50135550(4-{2-[(4-Chloro-pyridine-2-carbonyl)-amino]-3-fluo...)
Affinity DataIC50: <9nMAssay Description:Inhibitory activity against mouse liver glycogen phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50135550(4-{2-[(4-Chloro-pyridine-2-carbonyl)-amino]-3-fluo...)
Affinity DataIC50: <9nMAssay Description:Inhibitory activity against rat liver glycogen phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50133444(4-(2-Chloro-phenyl)-1-ethyl-5-isopropylcarbamoyl-6...)
Affinity DataIC50:  9.10nMAssay Description:In vitro inhibitory activity against human liver glycogen phosphorylase a (HLGPa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor IX(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50125977(CHEMBL3627897)
Affinity DataIC50:  10nMAssay Description:Inhibition of human factor 9a using CH3SO2-DCHG-Gly-Arg-AFC.AcOH as substrate preinubated for 30 mins followed by substrate addition measured after 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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