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Found 593 with Last Name = 'fitzek' and Initial = 'm'
LigandPNGBDBM50070262(CHEMBL3408270 | US9718800, 9.02b)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of PI3Kbeta in PTEN-null human MDA-MB-468 cells assessed as inhibition of Akt phosphorylation after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM7657(4-[(4-{imidazo[1,2-a]pyridin-3-yl}pyrimidin-2-yl)a...)
Affinity DataIC50:  1nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
LigandPNGBDBM50070324(CHEMBL3408252)
Affinity DataIC50:  1nMAssay Description:Inhibition of PI3Kbeta in PTEN-null human MDA-MB-468 cells assessed as inhibition of Akt phosphorylation after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50239117(CHEMBL4060768)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of PI3Kbeta in PTEN-deficient human MDA-MB-468 cells assessed as decrease in AKT phosphorylation at Ser473 measured after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50239123(CHEMBL4078233)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of PI3Kbeta in PTEN-deficient human MDA-MB-468 cells assessed as decrease in AKT phosphorylation at Ser473 measured after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50239122(CHEMBL4094771)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of PI3Kbeta in PTEN-deficient human MDA-MB-468 cells assessed as decrease in AKT phosphorylation at Ser473 measured after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50239120(CHEMBL4101005)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of PI3Kbeta in PTEN-deficient human MDA-MB-468 cells assessed as decrease in AKT phosphorylation at Ser473 measured after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50500920(CHEMBL3798914)
Affinity DataIC50:  2nMAssay Description:Inhibition of PI3Kbeta in PTEN deficient human MDA-MB-468 cells assessed as inhibition of AKT phosphorylation at Ser-473 residue after 2 hrs by plate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM119283(US8673906, 4.02 | US9718800, 4.02)
Affinity DataIC50:  2nMAssay Description:Inhibition of PI3Kbeta in PTEN-null human MDA-MB-468 cells assessed as inhibition of Akt phosphorylation after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50239126(CHEMBL4067312)
Affinity DataIC50:  2nMAssay Description:Inhibition of PI3Kbeta in PTEN-deficient human MDA-MB-468 cells assessed as decrease in AKT phosphorylation at Ser473 measured after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50500917(CHEMBL3797698)
Affinity DataIC50:  2nMAssay Description:Inhibition of PI3Kbeta in PTEN deficient human MDA-MB-468 cells assessed as inhibition of AKT phosphorylation at Ser-473 residue after 2 hrs by plate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50048722(CHEMBL3319646)
Affinity DataIC50:  2nMAssay Description:Inhibition of PI3Kbeta in human MAD-MB-468 cells assessed as inhibition of Ser473 Akt phosphorylation by cellular potency assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50070327(CHEMBL3408262)
Affinity DataIC50:  2nMAssay Description:Inhibition of PI3Kbeta in PTEN-null human MDA-MB-468 cells assessed as inhibition of Akt phosphorylation after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50239121(CHEMBL4082650)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of PI3Kbeta in PTEN-deficient human MDA-MB-468 cells assessed as decrease in AKT phosphorylation at Ser473 measured after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50239118(CHEMBL4090811)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of PI3Kbeta in PTEN-deficient human MDA-MB-468 cells assessed as decrease in AKT phosphorylation at Ser473 measured after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50500918(CHEMBL3799511)
Affinity DataIC50:  3nMAssay Description:Inhibition of PI3Kbeta in PTEN deficient human MDA-MB-468 cells assessed as inhibition of AKT phosphorylation at Ser-473 residue after 2 hrs by plate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50500922(CHEMBL3797812)
Affinity DataIC50:  3nMAssay Description:Inhibition of PI3Kbeta in PTEN deficient human MDA-MB-468 cells assessed as inhibition of AKT phosphorylation at Ser-473 residue after 2 hrs by plate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50349773(CHEMBL1809194)
Affinity DataIC50:  3nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50239125(CHEMBL4083021)
Affinity DataIC50:  3nMAssay Description:Inhibition of PI3Kbeta in PTEN-deficient human MDA-MB-468 cells assessed as decrease in AKT phosphorylation at Ser473 measured after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50048713(CHEMBL3319490)
Affinity DataIC50:  3nMAssay Description:Inhibition of PI3Kbeta in human MAD-MB-468 cells assessed as inhibition of Ser473 Akt phosphorylation by cellular potency assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50070210(CHEMBL3408267)
Affinity DataIC50:  3nMAssay Description:Inhibition of PI3Kbeta in PTEN-null human MDA-MB-468 cells assessed as inhibition of Akt phosphorylation after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50070322(CHEMBL3408248 | US9718800, 3.06b)
Affinity DataIC50:  3nMAssay Description:Inhibition of PI3Kbeta in PTEN-null human MDA-MB-468 cells assessed as inhibition of Akt phosphorylation after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50239127(CHEMBL4086125)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of PI3Kbeta in PTEN-deficient human MDA-MB-468 cells assessed as decrease in AKT phosphorylation at Ser473 measured after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50239124(CHEMBL4102511)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of PI3Kbeta in PTEN-deficient human MDA-MB-468 cells assessed as decrease in AKT phosphorylation at Ser473 measured after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50070327(CHEMBL3408262)
Affinity DataIC50:  4nMAssay Description:Inhibition of human recombinant PI3Kbeta using PIP2 by Kinase-Glo Plus assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50500924(CHEMBL3799158)
Affinity DataIC50:  4nMAssay Description:Inhibition of PI3Kbeta in PTEN deficient human MDA-MB-468 cells assessed as inhibition of AKT phosphorylation at Ser-473 residue after 2 hrs by plate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50070262(CHEMBL3408270 | US9718800, 9.02b)
Affinity DataIC50:  4nMAssay Description:Inhibition of human recombinant PI3Kbeta using PIP2 by Kinase-Glo Plus assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50070322(CHEMBL3408248 | US9718800, 3.06b)
Affinity DataIC50:  4nMAssay Description:Inhibition of human recombinant PI3Kbeta using PIP2 by Kinase-Glo Plus assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50048710(CHEMBL3319485)
Affinity DataIC50:  4nMAssay Description:Inhibition of PI3Kbeta in human MAD-MB-468 cells assessed as inhibition of Ser473 Akt phosphorylation by cellular potency assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50239119(CHEMBL4062879)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of PI3Kbeta in PTEN-deficient human MDA-MB-468 cells assessed as decrease in AKT phosphorylation at Ser473 measured after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50500929(CHEMBL3800231)
Affinity DataIC50:  5nMAssay Description:Inhibition of PI3Kbeta in PTEN deficient human MDA-MB-468 cells assessed as inhibition of AKT phosphorylation at Ser-473 residue after 2 hrs by plate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50253249(CHEMBL4093351)
Affinity DataIC50:  5nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50500917(CHEMBL3797698)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant PI3Kalpha using PIP2 as substrate preincubated for 20 mins followed by substrate addition measured after 80 mins by l...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50048713(CHEMBL3319490)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant PI3Kbeta assessed as depletion of ATP substrate by Ultra Glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50070324(CHEMBL3408252)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant PI3Kbeta using PIP2 by Kinase-Glo Plus assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50070323(CHEMBL3408250 | US9718800, 3.04b)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant PI3Kbeta using PIP2 by Kinase-Glo Plus assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50070325(CHEMBL3408256)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant PI3Kbeta using PIP2 by Kinase-Glo Plus assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50239118(CHEMBL4090811)
Affinity DataIC50:  5.10nMAssay Description:Displacement of [3H]baclofen from Gamma-aminobutyric acid type B receptor of rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50500915(CHEMBL3797750)
Affinity DataIC50:  6nMAssay Description:Inhibition of human recombinant PI3Kbeta using PIP2 as substrate preincubated for 20 mins followed by substrate addition measured after 80 mins by lu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50500920(CHEMBL3798914)
Affinity DataIC50:  6nMAssay Description:Inhibition of human recombinant PI3Kalpha using PIP2 as substrate preincubated for 20 mins followed by substrate addition measured after 80 mins by l...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50070326(CHEMBL3408257 | US9718800, 3.13b)
Affinity DataIC50:  6nMAssay Description:Inhibition of PI3Kbeta in PTEN-null human MDA-MB-468 cells assessed as inhibition of Akt phosphorylation after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50253251(CHEMBL4072637)
Affinity DataIC50:  6nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50500922(CHEMBL3797812)
Affinity DataIC50:  6nMAssay Description:Inhibition of human recombinant PI3Kbeta using PIP2 as substrate preincubated for 20 mins followed by substrate addition measured after 80 mins by lu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50070210(CHEMBL3408267)
Affinity DataIC50:  6nMAssay Description:Inhibition of human recombinant PI3Kbeta using PIP2 by Kinase-Glo Plus assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50500925(CHEMBL3799673)
Affinity DataIC50:  6nMAssay Description:Inhibition of PI3Kbeta in PTEN deficient human MDA-MB-468 cells assessed as inhibition of AKT phosphorylation at Ser-473 residue after 2 hrs by plate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50094479(CHEMBL3590225)
Affinity DataIC50:  6nMAssay Description:Inhibition of recombinant human PI3Kalpha using PIP2/ATP as substrate preincubated for 20 mins followed by substrate addition measured after 80 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50070318(CHEMBL3408277 | US9718800, 7.0b)
Affinity DataIC50:  6nMAssay Description:Inhibition of human recombinant PI3Kbeta using PIP2 by Kinase-Glo Plus assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50239118(CHEMBL4090811)
Affinity DataIC50:  6.10nMAssay Description:Inhibition of recombinant human PI3Kbeta using PIP2 as substrate preincubated for 20 mins followed by substrate addition measured after 80 mins in pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50239124(CHEMBL4102511)
Affinity DataIC50:  6.70nMAssay Description:Inhibition of recombinant human PI3Kbeta using PIP2 as substrate preincubated for 20 mins followed by substrate addition measured after 80 mins in pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50500918(CHEMBL3799511)
Affinity DataIC50:  7nMAssay Description:Inhibition of human recombinant PI3Kbeta using PIP2 as substrate preincubated for 20 mins followed by substrate addition measured after 80 mins by lu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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