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Found 167 with Last Name = 'gutierrez' and Initial = 'ja'
Target5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase(Escherichia coli (strain K12))
Albert Einstein College Of Medicine

LigandPNGBDBM36435((3R,4S)-1-[(9-Deaza-adenin-9-yl)methyl]-4-ethylthi...)
Affinity DataKi:  0.0700nM ΔG°:  -58.0kJ/molepH: 7.5 T: 2°CAssay Description:Purified MTAN activity in MTAN enzyme inhibition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase(Escherichia coli (strain K12))
Albert Einstein College Of Medicine

LigandPNGBDBM22113((3R,4S)-1-({4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-y...)
Affinity DataKi:  0.0730nM ΔG°:  -57.9kJ/molepH: 7.5 T: 2°CAssay Description:Purified MTAN activity in MTAN enzyme inhibition assayMore data for this Ligand-Target Pair
TargetS-methyl-5'-thioadenosine phosphorylase(Homo sapiens (Human))
Industrial Research

Curated by ChEMBL
LigandPNGBDBM22113((3R,4S)-1-({4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-y...)
Affinity DataKi:  0.0900nMAssay Description:Inhibition of human MTAP assessed as reduction in methylthioadenosine phosphorolysis/hydrolysisMore data for this Ligand-Target Pair
Target5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase(Escherichia coli (strain K12))
Albert Einstein College Of Medicine

LigandPNGBDBM36436((3R,4S)-1-[(9-Deaza-adenin-9-yl)methyl]-4-ethylthi...)
Affinity DataKi:  0.208nM ΔG°:  -55.3kJ/molepH: 7.5 T: 2°CAssay Description:Purified MTAN activity in MTAN enzyme inhibition assayMore data for this Ligand-Target Pair
TargetS-methyl-5'-thioadenosine phosphorylase(Homo sapiens (Human))
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50326399((+/-)-trans-4-Butyl-1-[(9-deazaadenin-9-yl)methyl]...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of His-tagged human MTAPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Homo sapiens (Human))
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50326399((+/-)-trans-4-Butyl-1-[(9-deazaadenin-9-yl)methyl]...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of His-tagged human MTAPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Homo sapiens (Human))
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50390240(CHEMBL1195586)
Affinity DataKi:  1nMAssay Description:Inhibition of human MTAP assessed as reduction in methylthioadenosine phosphorolysis/hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Homo sapiens (Human))
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50326400((+/-)-trans-1-[(9-Deazaadenin-9-yl)methyl]-3-hydro...)
Affinity DataKi:  1.70nMAssay Description:Inhibition of His-tagged human MTAPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Homo sapiens (Human))
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50326402((+/-)-trans-4-Cyclopropyl-1-[(9-deazaadenin-9-yl)m...)
Affinity DataKi:  2.10nMAssay Description:Inhibition of His-tagged human MTAPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Homo sapiens (Human))
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50326403((+/-)-trans-4-Cyclopentyl-1-[(9-deazaadenin-9-yl)m...)
Affinity DataKi:  2.60nMAssay Description:Inhibition of His-tagged human MTAPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Homo sapiens (Human))
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50326407((+/-)-trans-4-Allyl-1-[(9-deazaadenin-9-yl)methyl]...)
Affinity DataKi:  3nMAssay Description:Inhibition of His-tagged human MTAPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Homo sapiens (Human))
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50326406((+/-)-trans-1-[(9-Deazaadenin-9-yl)methyl]-3-hydro...)
Affinity DataKi:  3.20nMAssay Description:Inhibition of His-tagged human MTAPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Homo sapiens (Human))
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50326398((+/-)-trans-1-[(9-Deazaadenin-9-yl)methyl]-4-ethyl...)
Affinity DataKi:  3.20nMAssay Description:Inhibition of His-tagged human MTAPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Homo sapiens (Human))
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50326398((+/-)-trans-1-[(9-Deazaadenin-9-yl)methyl]-4-ethyl...)
Affinity DataKi:  3.20nMAssay Description:Inhibition of His-tagged human MTAPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Homo sapiens (Human))
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50390242(CHEMBL2070308)
Affinity DataKi:  4.40nMAssay Description:Inhibition of human MTAP assessed as reduction in methylthioadenosine phosphorolysis/hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKetohexokinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM319585(US10174007, Example 4 | US10787438, Example 4 | US...)
Affinity DataKi:  4.5nMAssay Description:Mixed noncompetitive inhibition of recombinant human N-terminal His-tagged KHKC expressed in Escherichia coli BL21 (DE3) using fructose as substrate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Homo sapiens (Human))
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50390245(CHEMBL2070311)
Affinity DataKi:  5.20nMAssay Description:Inhibition of human MTAP assessed as reduction in methylthioadenosine phosphorolysis/hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Homo sapiens (Human))
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50326405((+/-)-trans-1-[(9-Deazaadenin-9-yl)methyl]-3-hydro...)
Affinity DataKi:  8nMAssay Description:Inhibition of His-tagged human MTAPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Homo sapiens (Human))
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50390244(CHEMBL2070310)
Affinity DataKi:  10nMAssay Description:Inhibition of human MTAP assessed as reduction in methylthioadenosine phosphorolysis/hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Homo sapiens (Human))
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50390241(CHEMBL2070307)
Affinity DataKi:  12nMAssay Description:Inhibition of human MTAP assessed as reduction in methylthioadenosine phosphorolysis/hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Homo sapiens (Human))
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50390255(CHEMBL2070405)
Affinity DataKi:  12nMAssay Description:Inhibition of human MTAP assessed as reduction in methylthioadenosine phosphorolysis/hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Homo sapiens (Human))
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50326404((+/-)-trans-4-(Cyclohexylmethyl)-1-[(9-deaza-adeni...)
Affinity DataKi:  14nMAssay Description:Inhibition of His-tagged human MTAPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Homo sapiens (Human))
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50326401((+/-)-trans-1-[(9-Deazaadenin-9-yl)methyl]-3-hydro...)
Affinity DataKi:  18nMAssay Description:Inhibition of His-tagged human MTAPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Homo sapiens (Human))
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50326408((+/-)-trans-1-[(9-Deazaadenin-9-yl)methyl]-4-ethyn...)
Affinity DataKi:  31nMAssay Description:Inhibition of His-tagged human MTAPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Homo sapiens (Human))
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50326411((+/-)-Benzyl cis-3-(Benzoyloxy)-4-ethylpyrrolidine...)
Affinity DataKi:  34nMAssay Description:Inhibition of His-tagged human MTAPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Homo sapiens (Human))
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50390251(CHEMBL2070404)
Affinity DataKi:  34nMAssay Description:Inhibition of human MTAP assessed as reduction in methylthioadenosine phosphorolysis/hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Homo sapiens (Human))
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50390249(CHEMBL2070402)
Affinity DataKi:  34nMAssay Description:Inhibition of human MTAP assessed as reduction in methylthioadenosine phosphorolysis/hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Homo sapiens (Human))
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50390248(CHEMBL2070401)
Affinity DataKi:  34nMAssay Description:Inhibition of human MTAP assessed as reduction in methylthioadenosine phosphorolysis/hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Homo sapiens (Human))
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50390243(CHEMBL2070309)
Affinity DataKi:  34nMAssay Description:Inhibition of human MTAP assessed as reduction in methylthioadenosine phosphorolysis/hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Homo sapiens (Human))
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50326409((+/-)-trans-1-[(9-Deazaadenin-9-yl)methyl]-3-hydro...)
Affinity DataKi:  59nMAssay Description:Inhibition of His-tagged human MTAPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Homo sapiens (Human))
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50326410((+/-)-trans-4-[3-(Benzylthio)propyl]-1-[(9-deazaad...)
Affinity DataKi:  71nMAssay Description:Inhibition of His-tagged human MTAPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Homo sapiens (Human))
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50390247(CHEMBL2070400)
Affinity DataKi:  87nMAssay Description:Inhibition of human MTAP assessed as reduction in methylthioadenosine phosphorolysis/hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Homo sapiens (Human))
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50390246(CHEMBL2070312)
Affinity DataKi:  87nMAssay Description:Inhibition of human MTAP assessed as reduction in methylthioadenosine phosphorolysis/hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Homo sapiens (Human))
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50390252(CHEMBL2070406)
Affinity DataKi:  105nMAssay Description:Inhibition of human MTAP assessed as reduction in methylthioadenosine phosphorolysis/hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Homo sapiens (Human))
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50390254(CHEMBL2070408)
Affinity DataKi:  130nMAssay Description:Inhibition of human MTAP assessed as reduction in methylthioadenosine phosphorolysis/hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Homo sapiens (Human))
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50390253(CHEMBL2070407)
Affinity DataKi:  368nMAssay Description:Inhibition of human MTAP assessed as reduction in methylthioadenosine phosphorolysis/hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Homo sapiens (Human))
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50390250(CHEMBL2070403)
Affinity DataKi:  602nMAssay Description:Inhibition of human MTAP assessed as reduction in methylthioadenosine phosphorolysis/hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKetohexokinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM319582(US10174007, Example 1 | US10787438, Example 1 | US...)
Affinity DataIC50:  1nMAssay Description:Inhibition of 1 nM recombinant human N-terminal His-tagged KHKC expressed in Escherichia coli BL21 (DE3) using fructose as substrate preincubated for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM195575((R)-(3-(4-(2-morpholinopyrimidin-5-yl)phenyl)-1H-1...)
Affinity DataIC50:  5nMpH: 7.5Assay Description:For determination of IC50 values for CES1 inhibitors, the reactions were carried out in 1.5 mL microcentrifuge tubes in a total reaction volume of 25...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM195574((R)-(2-phenylpiperidin-1-yl)(3-(4-(pyridin-3-yl)ph...)
Affinity DataIC50:  5nMpH: 7.5Assay Description:For determination of IC50 values for CES1 inhibitors, the reactions were carried out in 1.5 mL microcentrifuge tubes in a total reaction volume of 25...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM195572((R)-N,N-dimethyl-4'-(2-(2-phenylpiperidine-1-c...)
Affinity DataIC50: <5nMpH: 7.5Assay Description:For determination of IC50 values for CES1 inhibitors, the reactions were carried out in 1.5 mL microcentrifuge tubes in a total reaction volume of 25...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM195571((R)-4'-(2-(2-phenylpiperidine-1-carbonyl)-2H-1...)
Affinity DataIC50: <5nMpH: 7.5Assay Description:For determination of IC50 values for CES1 inhibitors, the reactions were carried out in 1.5 mL microcentrifuge tubes in a total reaction volume of 25...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM195570((S)-4'-(2-(2-phenylpiperidine-1-carbonyl)-2H-1...)
Affinity DataIC50: <5nMpH: 7.5Assay Description:For determination of IC50 values for CES1 inhibitors, the reactions were carried out in 1.5 mL microcentrifuge tubes in a total reaction volume of 25...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysophospholipase-like protein 1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM195581((2R,3R)-2-(3-ethynylphenyl)-1-(3-(4-(2-morpholinop...)
Affinity DataIC50:  5nMpH: 7.5Assay Description:For determination of IC50 values for LYPLAL1 inhibitors, the reactions were carried out in 1.5 mL microcentrifuge tubes in a total reaction volume of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKetohexokinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM319582(US10174007, Example 1 | US10787438, Example 1 | US...)
Affinity DataIC50:  6nMAssay Description:Inhibition of 10 nM recombinant human N-terminal His-tagged KHKC expressed in Escherichia coli BL21 (DE3) using fructose as substrate preincubated fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysophospholipase-like protein 1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM195580((2R,3R)-1-(3-(4-(2-morpholinopyrimidin-5-yl)phenyl...)
Affinity DataIC50:  6nMpH: 7.5Assay Description:For determination of IC50 values for LYPLAL1 inhibitors, the reactions were carried out in 1.5 mL microcentrifuge tubes in a total reaction volume of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM195573((R)-4'-(1-(2-phenylpiperidine-1-carbonyl)-1H-1...)
Affinity DataIC50:  7nMpH: 7.5Assay Description:For determination of IC50 values for CES1 inhibitors, the reactions were carried out in 1.5 mL microcentrifuge tubes in a total reaction volume of 25...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysophospholipase-like protein 1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM195575((R)-(3-(4-(2-morpholinopyrimidin-5-yl)phenyl)-1H-1...)
Affinity DataIC50:  7nMpH: 7.5Assay Description:For determination of IC50 values for LYPLAL1 inhibitors, the reactions were carried out in 1.5 mL microcentrifuge tubes in a total reaction volume of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKetohexokinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM319585(US10174007, Example 4 | US10787438, Example 4 | US...)
Affinity DataIC50:  10nMAssay Description:Inhibition of 1 nM recombinant human N-terminal His-tagged KHKC expressed in Escherichia coli BL21 (DE3) using fructose as substrate preincubated for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysophospholipase-like protein 1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM195578((2R, 4R)-1-(3-(4-(2-morpholinopyrimidin-5-yl)pheny...)
Affinity DataIC50:  11nMpH: 7.5Assay Description:For determination of IC50 values for LYPLAL1 inhibitors, the reactions were carried out in 1.5 mL microcentrifuge tubes in a total reaction volume of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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