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Found 549 with Last Name = 'hwang' and Initial = 'sy'
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50080882(Benzamidrazone analogue | CHEMBL312244)
Affinity DataKi:  0.0600nMAssay Description:Inhibitory constant of the compound against human thrombin was determined in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50080879(Benzamidrazone analogue | CHEMBL82057)
Affinity DataKi:  0.100nMAssay Description:Inhibitory constant of the compound against human thrombin was determined in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50080885(Benzamidrazone analogue | CHEMBL79304)
Affinity DataKi:  0.200nMAssay Description:Inhibitory constant of the compound against human thrombin was determined in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50080883(Benzamidrazone analogue | CHEMBL310664)
Affinity DataKi:  0.200nMAssay Description:Inhibitory constant of the compound against human thrombin was determined in vitroMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50069294((S)-3-[4-(carbohydrazonamidol)-phenyl]-N-cyclopent...)
Affinity DataKi:  0.380nMAssay Description:Compound was evaluated for its inhibitory activity against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50069294((S)-3-[4-(carbohydrazonamidol)-phenyl]-N-cyclopent...)
Affinity DataKi:  0.380nMAssay Description:Compound was tested for inhibitory activity against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50069294((S)-3-[4-(carbohydrazonamidol)-phenyl]-N-cyclopent...)
Affinity DataKi:  0.400nMAssay Description:Inhibitory constant of the compound against human thrombin was determined in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50085048((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(methyl-pyri...)
Affinity DataKi:  0.430nMAssay Description:Binding affinity to PPARgamma (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50070780((S)-3-(5-Carbamimidoyl-thiophen-2-yl)-N-cyclopenty...)
Affinity DataKi:  0.490nMAssay Description:Compound was evaluated for its inhibitory activity against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50080888(Benzamidrazone analogue | CHEMBL84454)
Affinity DataKi:  0.5nMAssay Description:Inhibitory constant of the compound against human thrombin was determined in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50070785((S)-3-(5-Carbamimidoyl-thiophen-2-yl)-N-cyclopenty...)
Affinity DataKi:  0.600nMAssay Description:Compound was evaluated for its inhibitory activity against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50080886(Benzamidrazone analogue | CHEMBL313296)
Affinity DataKi:  0.700nMAssay Description:Inhibitory constant of the compound against human thrombin was determined in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM28661(2-{2-methyl-4-[({4-methyl-2-[4-(trifluoromethyl)ph...)
Affinity DataKi:  0.820nMAssay Description:Binding affinity to PPARdelta (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50070782((S)-3-(4-Carbamimidoyl-phenyl)-N-cyclopentyl-N-met...)
Affinity DataKi:  0.840nMAssay Description:Compound was evaluated for its inhibitory activity against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50080884(Benzamidrazone analogue | CHEMBL314189)
Affinity DataKi:  0.900nMAssay Description:Inhibitory constant of the compound against human thrombin was determined in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50085048((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(methyl-pyri...)
Affinity DataKi:  1nMAssay Description:Binding affinity to PPARgamma (unknown origin) assessed as inhibition constant by Lanthascreen TR-FRET assay relative to controlMore data for this Ligand-Target Pair
TargetProthrombin(Bos taurus (Bovine))
TBA

Curated by ChEMBL
LigandPNGBDBM50291355(1-[3-[4-amino(amineimino)methylphenyl]-2-(2-anthry...)
Affinity DataKi:  1nMAssay Description:Inhibitory effect against bovine thrombinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Bos taurus (Bovine))
TBA

Curated by ChEMBL
LigandPNGBDBM50069294((S)-3-[4-(carbohydrazonamidol)-phenyl]-N-cyclopent...)
Affinity DataKi:  1.10nMAssay Description:Compound was tested for inhibitory activity against bovine thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50099491(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity to PPARalpha (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
TargetProthrombin(Bos taurus (Bovine))
TBA

Curated by ChEMBL
LigandPNGBDBM50069297(1-[3-[4-amino(amineimino)methylphenyl]-2-(2-naphth...)
Affinity DataKi:  1.5nMAssay Description:Inhibitory effect against bovine thrombinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50080880(Benzamidrazone analogue | CHEMBL312011)
Affinity DataKi:  1.80nMAssay Description:Inhibitory constant of the compound against human thrombin was determined in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50080881(Benzamidrazone analogue | CHEMBL82072)
Affinity DataKi:  2nMAssay Description:Inhibitory constant of the compound against human thrombin was determined in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50070784((S)-3-(5-Carbamimidoyl-thiophen-2-yl)-N-cyclopenty...)
Affinity DataKi:  3nMAssay Description:Compound was evaluated for its inhibitory activity against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
TBA

Curated by ChEMBL
LigandPNGBDBM50069292(CHEMBL156082 | N-ethyl-N-cyclopentyl-3-(4-hydrazon...)
Affinity DataKi:  4nMAssay Description:Compound was tested for inhibitory activity against bovine thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50076722((S)-5-(4-Methylamino-phenyl)-2-(5,6,7,8-tetrahydro...)
Affinity DataKi:  5nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50080887(Benzamidrazone analogue | CHEMBL83205)
Affinity DataKi:  5.5nMAssay Description:Inhibitory constant of the compound against human thrombin was determined in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
TBA

Curated by ChEMBL
LigandPNGBDBM50037996(1-[N-(naphthalen-2-ylsulfonyl)glycyl-4-carbamimido...)
Affinity DataKi:  6.5nMAssay Description:Inhibitory effect against bovine thrombinMore data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50070783((S)-3-(4-Carbamimidoyl-phenyl)-N-cyclopentyl-N-met...)
Affinity DataKi:  6.80nMAssay Description:Compound was evaluated for its inhibitory activity against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50076730((S)-5-(4-Methylamino-phenyl)-2-(4-propyl-benzenesu...)
Affinity DataKi:  8nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50076724((S)-5-(4-Methylamino-phenyl)-2-(naphthalene-2-sulf...)
Affinity DataKi:  19nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
TBA

Curated by ChEMBL
LigandPNGBDBM50291363(CHEMBL354307 | N-[(R)-2-Azepan-1-yl-1-(4-carbamimi...)
Affinity DataKi:  20nMAssay Description:Inhibitory effect against bovine thrombinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50076725((S)-2-(6-Methoxy-naphthalene-2-sulfonylamino)-5-(4...)
Affinity DataKi:  27nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50076723((S)-5-(3-Amino-4-methylamino-phenyl)-2-(naphthalen...)
Affinity DataKi:  40nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
TBA

Curated by ChEMBL
LigandPNGBDBM50069293(CHEMBL440188 | N-methyl-N-n-butyl-3-(4-hydrazonofo...)
Affinity DataKi:  41nMAssay Description:Compound was tested for inhibitory activity against bovine thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
TBA

Curated by ChEMBL
LigandPNGBDBM50291361(4-[(S)-3-Azepan-1-yl-2-(naphthalene-2-sulfonylamin...)
Affinity DataKi:  46nMAssay Description:Inhibitory effect against bovine thrombinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Bos taurus (Bovine))
TBA

Curated by ChEMBL
LigandPNGBDBM50291357(4-[(S)-2-(Anthracene-2-sulfonylamino)-3-azepan-1-y...)
Affinity DataKi:  50nMAssay Description:Inhibitory effect against bovine thrombinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Bos taurus (Bovine))
TBA

Curated by ChEMBL
LigandPNGBDBM50291358(4-[(S)-3-Azepan-1-yl-2-(naphthalene-2-sulfonylamin...)
Affinity DataKi:  52nMAssay Description:Inhibitory effect against bovine thrombinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50070781(1N-cyclopentyl-1N-methyl-3-[5-amino(aminoimino)met...)
Affinity DataKi:  91nMAssay Description:Compound was evaluated for its inhibitory activity against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
TBA

Curated by ChEMBL
LigandPNGBDBM50069296(CHEMBL347371 | N-(n-propyl)-N-cyclopentyl-3-(4-hyd...)
Affinity DataKi:  93nMAssay Description:Compound was tested for inhibitory activity against bovine thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-protein thioesterase 2(Homo sapiens (Human))
University Of Michigan

LigandPNGBDBM207992(ML349)
Affinity DataKi:  120nMpH: 6.5Assay Description:Enzymes were diluted to 10 nM in PBS pH 6.5 (adjusted with sodium acetate) supplemented with 0.1 g/L pluronic F127 (Sigma). Varying concentrations of...More data for this Ligand-Target Pair
TargetAcyl-protein thioesterase 2(Homo sapiens (Human))
University Of Michigan

LigandPNGBDBM207992(ML349)
Affinity DataKi:  120nMAssay Description:Competitive inhibition of HEK293T cells-derived His-tagged APT2 expressed in Escherichia coli BL21(DE3) preincubated for 30 mins followed by substrat...More data for this Ligand-Target Pair
TargetAcyl-protein thioesterase 2 [P86Q](Homo sapiens (Human))
University Of Michigan

LigandPNGBDBM207992(ML349)
Affinity DataKi:  130nMpH: 6.5Assay Description:Enzymes were diluted to 10 nM in PBS pH 6.5 (adjusted with sodium acetate) supplemented with 0.1 g/L pluronic F127 (Sigma). Varying concentrations of...More data for this Ligand-Target Pair
TargetSerine protease 1(Bos taurus (bovine))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50070780((S)-3-(5-Carbamimidoyl-thiophen-2-yl)-N-cyclopenty...)
Affinity DataKi:  134nMAssay Description:Compound was evaluated for its inhibitory activity against bovine trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50070785((S)-3-(5-Carbamimidoyl-thiophen-2-yl)-N-cyclopenty...)
Affinity DataKi:  150nMAssay Description:Compound was evaluated for its inhibitory activity against bovine trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
TBA

Curated by ChEMBL
LigandPNGBDBM50069298(CHEMBL434678 | N-methyl-N-cyclohexyl-3-(4-hydrazon...)
Affinity DataKi:  152nMAssay Description:Compound was tested for inhibitory activity against bovine thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50070784((S)-3-(5-Carbamimidoyl-thiophen-2-yl)-N-cyclopenty...)
Affinity DataKi:  153nMAssay Description:Compound was evaluated for its inhibitory activity against bovine trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-protein thioesterase 1 [I75L,S82A,Q83P,R149H,A150R,S151A](Homo sapiens (Human))
University Of Michigan

LigandPNGBDBM207992(ML349)
Affinity DataKi:  180nMpH: 6.5Assay Description:Enzymes were diluted to 10 nM in PBS pH 6.5 (adjusted with sodium acetate) supplemented with 0.1 g/L pluronic F127 (Sigma). Varying concentrations of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-protein thioesterase 2 [M178L](Homo sapiens (Human))
University Of Michigan

LigandPNGBDBM207992(ML349)
Affinity DataKi:  200nMpH: 6.5Assay Description:Enzymes were diluted to 10 nM in PBS pH 6.5 (adjusted with sodium acetate) supplemented with 0.1 g/L pluronic F127 (Sigma). Varying concentrations of...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50085045(5-((4-((6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-...)
Affinity DataKi:  200nMAssay Description:Binding affinity to PPARgamma (unknown origin) assessed as inhibition constant by Lanthascreen TR-FRET assay relative to controlMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProthrombin(Homo sapiens (Human))
Biotech Research Institute

Curated by ChEMBL
LigandPNGBDBM50076728((S)-5-(3,4-Diamino-phenyl)-2-(naphthalene-2-sulfon...)
Affinity DataKi:  220nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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