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Found 425 with Last Name = 'kafarski' and Initial = 'p'
TargetCytosol aminopeptidase(Homo sapiens (Human))
Wroclaw University Of Technology

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataKi:  0.600nMAssay Description:Binding affinity for cytosolic leucine aminopeptidase (LAP) from porcine kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Wroclaw University Of Technology

Curated by ChEMBL
LigandPNGBDBM50303320((S)-2-[(R)-3-[((R)-1-Benzyloxycarbonylamino-2-phen...)
Affinity DataKi:  0.650nMAssay Description:Inhibition of human ACE C-terminal domain expressed in CHO cells after 90 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Wroclaw University Of Technology

Curated by ChEMBL
LigandPNGBDBM50018849(4-Cyclohexyl-1-{2-[hydroxy-(4-phenyl-butyl)-phosph...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of ACEMore data for this Ligand-Target Pair
TargetAminopeptidase N(Homo sapiens (Human))
Wroclaw University Of Technology

Curated by ChEMBL
LigandPNGBDBM50393210(CHEMBL1235787)
Affinity DataKi:  2.20nMAssay Description:Inhibition of APNMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Wroclaw University Of Technology

Curated by ChEMBL
LigandPNGBDBM50393211(CHEMBL2153737)
Affinity DataKi:  2.5nMAssay Description:Inhibition of MMP-8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Wroclaw University Of Technology

Curated by ChEMBL
LigandPNGBDBM50303327((2S)-2-((1S,2S)-2-(((R)-1-(benzyloxycarbonylamino)...)
Affinity DataKi:  3nMAssay Description:Inhibition of human ACE C-terminal domain expressed in CHO cells after 90 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetStromelysin-3(Homo sapiens (Human))
Wroclaw University Of Technology

Curated by ChEMBL
LigandPNGBDBM50393211(CHEMBL2153737)
Affinity DataKi:  5nMAssay Description:Inhibition of MMP-11More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Wroclaw University Of Technology

Curated by ChEMBL
LigandPNGBDBM50393213(CHEMBL1235767)
Affinity DataKi:  7nMAssay Description:Inhibition of human ACE N-terminal domain expressed in CHO cells after 90 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Wroclaw University Of Technology

Curated by ChEMBL
LigandPNGBDBM50393211(CHEMBL2153737)
Affinity DataKi:  10nMAssay Description:Inhibition of MMP-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50135836(1-(2-Hydroxy-2,2-bis-phosphono-ethyl)-3H-imidazol-...)
Affinity DataKi:  10nMAssay Description:Binding affinity towards farnesyl Pyrophosphate Synthase using [14C]- isopentenyl pyrophosphate as radioligandMore data for this Ligand-Target Pair
TargetFarnesyl pyrophosphate synthase(Leishmania major)
Wroclaw University Of Technology

Curated by ChEMBL
LigandPNGBDBM50098390((3-methylpyridin-2-ylamino)methylenediphosphonic a...)
Affinity DataKi:  11nMAssay Description:Inhibition of Leishmania major FPPSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50098390((3-methylpyridin-2-ylamino)methylenediphosphonic a...)
Affinity DataKi:  11nMAssay Description:Binding affinity towards farnesyl Pyrophosphate Synthase using [14C]- isopentenyl pyrophosphate as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50098378((1-Hydroxy-1-phosphono-2-pyridin-2-yl-ethyl)-phosp...)
Affinity DataKi:  14nMAssay Description:Binding affinity towards farnesyl Pyrophosphate Synthase using [14C]- isopentenyl pyrophosphate as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50135818((pyridin-3-ylamino)methylenediphosphonic acid | 3-...)
Affinity DataKi:  15nMAssay Description:Binding affinity towards farnesyl Pyrophosphate Synthase using [14C]- isopentenyl pyrophosphate as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50115115((Cyclohexylamino-phosphono-methyl)-phosphonic acid...)
Affinity DataKi:  16nMAssay Description:Binding affinity towards farnesyl Pyrophosphate Synthase using [14C]- isopentenyl pyrophosphate as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50115106(2-(pyridin-2-ylamino)ethane-1,1-diyldiphosphonic a...)
Affinity DataKi:  16nMAssay Description:Binding affinity towards farnesyl Pyrophosphate Synthase using [14C]- isopentenyl pyrophosphate as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM12576(Bisphosphonate 1 | CHEMBL923 | JMC515594 Compound ...)
Affinity DataKi:  16nMAssay Description:Binding affinity towards farnesyl Pyrophosphate Synthase using [14C]- isopentenyl pyrophosphate as radioligandMore data for this Ligand-Target Pair
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50113291((4-methylpyridin-2-ylamino)methylenediphosphonic a...)
Affinity DataKi:  17nMAssay Description:Binding affinity towards farnesyl Pyrophosphate Synthase using [14C]- isopentenyl pyrophosphate as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50115104((pyridin-2-ylamino)methylenediphosphonic acid | 2-...)
Affinity DataKi:  20nMAssay Description:Binding affinity towards farnesyl Pyrophosphate Synthase using [14C]- isopentenyl pyrophosphate as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Wroclaw University Of Technology

Curated by ChEMBL
LigandPNGBDBM50393211(CHEMBL2153737)
Affinity DataKi:  20nMAssay Description:Inhibition of MMP-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50135817((Bis-phosphono-methyl)-butyl-ammonium | (Butylamin...)
Affinity DataKi:  20nMAssay Description:Binding affinity towards farnesyl Pyrophosphate Synthase using [14C]- isopentenyl pyrophosphate as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50135821((Bis-phosphono-methyl)-cycloheptyl-ammonium | (Cyc...)
Affinity DataKi:  22nMAssay Description:Binding affinity towards farnesyl Pyrophosphate Synthase using [14C]- isopentenyl pyrophosphate as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50115109((5-chloropyridin-2-ylamino)methylenediphosphonic a...)
Affinity DataKi:  23nMAssay Description:Binding affinity towards farnesyl Pyrophosphate Synthase using [14C]- isopentenyl pyrophosphate as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50135839(CHEMBL55464 | [1-Hydroxy-3-(4-phenyl-butylamino)-1...)
Affinity DataKi:  24nMAssay Description:Binding affinity towards farnesyl Pyrophosphate Synthase using [14C]- isopentenyl pyrophosphate as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Wroclaw University Of Technology

Curated by ChEMBL
LigandPNGBDBM50393212(CHEMBL2153739)
Affinity DataKi:  28nMAssay Description:Inhibition of MMP-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50117260(1-hydroxy-3-(methyl(phenethyl)amino)propane-1,1-di...)
Affinity DataKi:  30nMAssay Description:Binding affinity towards farnesyl Pyrophosphate Synthase using [14C]- isopentenyl pyrophosphate as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50098389(1-hydroxy-2-(1H-imidazol-5-yl)ethane-1,1-diyldipho...)
Affinity DataKi:  30nMAssay Description:Binding affinity towards farnesyl Pyrophosphate Synthase using [14C]- isopentenyl pyrophosphate as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytosol aminopeptidase(Homo sapiens (Human))
Wroclaw University Of Technology

Curated by ChEMBL
LigandPNGBDBM50017478(Amastatin | CHEMBL28650 | Leu[1psi,CHOHCONH]ValVal...)
Affinity DataKi:  30nMAssay Description:Binding affinity for cytosolic leucine aminopeptidase (LAP) from porcine kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50115110((Pentylamino-phosphono-methyl)-phosphonic acid | (...)
Affinity DataKi:  33nMAssay Description:Binding affinity towards farnesyl Pyrophosphate Synthase using [14C]- isopentenyl pyrophosphate as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50135833((2-methylbutyl)aminomethylene-1,1-bisphosphonate |...)
Affinity DataKi:  34nMAssay Description:Binding affinity towards farnesyl Pyrophosphate Synthase using [14C]- isopentenyl pyrophosphate as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase N(Sus scrofa (Pig))
Wroclaw University Of Technology

Curated by ChEMBL
LigandPNGBDBM50129681(3-[(1-Amino-3-phenyl-propyl)-hydroxy-phosphinoyl]-...)
Affinity DataKi:  36nMAssay Description:Binding affinity towards aminopeptidase N (APN) from pig kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50135820(2-(pyridin-4-ylamino)ethane-1,1-diyldiphosphonic a...)
Affinity DataKi:  40nMAssay Description:Binding affinity towards farnesyl Pyrophosphate Synthase using [14C]- isopentenyl pyrophosphate as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50135835((isoquinolin-1-ylamino)methylenediphosphonic acid ...)
Affinity DataKi:  41nMAssay Description:Binding affinity towards farnesyl Pyrophosphate Synthase using [14C]- isopentenyl pyrophosphate as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50135831(CHEMBL316844 | [1-Hydroxy-3-(3-phenoxy-propylamino...)
Affinity DataKi:  43nMAssay Description:Binding affinity towards farnesyl Pyrophosphate Synthase using [14C]- isopentenyl pyrophosphate as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytosol aminopeptidase(Homo sapiens (Human))
Wroclaw University Of Technology

Curated by ChEMBL
LigandPNGBDBM50225458((2S)-3-[(R)-[(1S)-1-amino-3-phenylpropyl](hydroxy)...)
Affinity DataKi:  45nMAssay Description:Inhibition of pig kidney cytosolic leucine aminopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM25290(CHEMBL56073 | bisphosphonate, 39 | {1-hydroxy-3-[m...)
Affinity DataKi:  46nMAssay Description:Binding affinity towards farnesyl Pyrophosphate Synthase using [14C]- isopentenyl pyrophosphate as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM12577(Bisphosphonate 2 | CHEMBL997 | JMC515594 Compound ...)
Affinity DataKi:  46nMAssay Description:Binding affinity towards farnesyl Pyrophosphate Synthase using [14C]- isopentenyl pyrophosphate as radioligandMore data for this Ligand-Target Pair
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50115112((Bis-phosphono-methyl)-(3-methyl-butyl)-ammonium |...)
Affinity DataKi:  47nMAssay Description:Binding affinity towards farnesyl Pyrophosphate Synthase using [14C]- isopentenyl pyrophosphate as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50117257(1-hydroxy-3-(methyl(3-phenylpropyl)amino)propane-1...)
Affinity DataKi:  47nMAssay Description:Binding affinity towards farnesyl Pyrophosphate Synthase using [14C]- isopentenyl pyrophosphate as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50135838((Azepan-1-yl-phosphono-methyl)-phosphonic acid | 1...)
Affinity DataKi:  49nMAssay Description:Binding affinity towards farnesyl Pyrophosphate Synthase using [14C]- isopentenyl pyrophosphate as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50135824((Bis-phosphono-methyl)-cyclopentyl-ammonium | (Cyc...)
Affinity DataKi:  52nMAssay Description:Binding affinity towards farnesyl Pyrophosphate Synthase using [14C]- isopentenyl pyrophosphate as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytosol aminopeptidase(Homo sapiens (Human))
Wroclaw University Of Technology

Curated by ChEMBL
LigandPNGBDBM50129685(2-Amino-4-methyl-pentanal | CHEMBL88476)
Affinity DataKi:  60nMAssay Description:Binding affinity for cytosolic leucine aminopeptidase (LAP) from porcine kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytosol aminopeptidase(Homo sapiens (Human))
Wroclaw University Of Technology

Curated by ChEMBL
LigandPNGBDBM50129683(2-[(1-Amino-3-methyl-butyl)-hydroxy-phosphinoylmet...)
Affinity DataKi:  65nMAssay Description:Binding affinity for cytosolic leucine aminopeptidase (LAP) from porcine kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytosol aminopeptidase(Homo sapiens (Human))
Wroclaw University Of Technology

Curated by ChEMBL
LigandPNGBDBM50129683(2-[(1-Amino-3-methyl-butyl)-hydroxy-phosphinoylmet...)
Affinity DataKi:  65nMAssay Description:Inhibition of LAPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytosol aminopeptidase(Homo sapiens (Human))
Wroclaw University Of Technology

Curated by ChEMBL
LigandPNGBDBM50129683(2-[(1-Amino-3-methyl-butyl)-hydroxy-phosphinoylmet...)
Affinity DataKi:  65nMAssay Description:Binding affinity for cytosolic leucine aminopeptidase (LAP) from porcine kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytosol aminopeptidase(Homo sapiens (Human))
Wroclaw University Of Technology

Curated by ChEMBL
LigandPNGBDBM50129684(3-[(1-amino-3-phenyl-propyl)-hydroxy-phosphinoyl]-...)
Affinity DataKi:  66nMAssay Description:Binding affinity for cytosolic leucine aminopeptidase (LAP) from porcine kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytosol aminopeptidase(Homo sapiens (Human))
Wroclaw University Of Technology

Curated by ChEMBL
LigandPNGBDBM50129684(3-[(1-amino-3-phenyl-propyl)-hydroxy-phosphinoyl]-...)
Affinity DataKi:  66nMAssay Description:Inhibition of pig kidney cytosolic leucine aminopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytosol aminopeptidase(Homo sapiens (Human))
Wroclaw University Of Technology

Curated by ChEMBL
LigandPNGBDBM50129681(3-[(1-Amino-3-phenyl-propyl)-hydroxy-phosphinoyl]-...)
Affinity DataKi:  67nMAssay Description:Binding affinity for cytosolic leucine aminopeptidase (LAP) from porcine kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytosol aminopeptidase(Homo sapiens (Human))
Wroclaw University Of Technology

Curated by ChEMBL
LigandPNGBDBM50129682(2-[(1-Amino-3-phenyl-propyl)-hydroxy-phosphinoylme...)
Affinity DataKi:  74nMAssay Description:Binding affinity for cytosolic leucine aminopeptidase (LAP) from porcine kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50135823((Isobutylamino-phosphono-methyl)-phosphonic acid |...)
Affinity DataKi:  75nMAssay Description:Binding affinity towards farnesyl Pyrophosphate Synthase using [14C]- isopentenyl pyrophosphate as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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