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Found 98 with Last Name = 'kelley' and Initial = 'jl'
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50042365(CHEMBL117417 | [3-(2-Amino-6-oxo-1,6-dihydro-purin...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of purine nucleoside phosphorylase of human erythrocytes in xanthine oxidase-coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50033660(CHEMBL269745 | {[5-(2-Amino-6-oxo-1,6-dihydro-puri...)
Affinity DataKi:  3.10nMAssay Description:Inhibition of human erythrocyte purine nucleoside phosphorylase (PNPase) in the presence of zinc chlorideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50033663(CHEMBL7319 | {[6-(2-Amino-6-oxo-1,6-dihydro-purin-...)
Affinity DataKi:  3.70nMAssay Description:Inhibition of human erythrocyte purine nucleoside phosphorylase (PNPase) in the presence of zinc chlorideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50033666(2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methox...)
Affinity DataKi:  4.20nMAssay Description:Inhibition of human erythrocyte purine nucleoside phosphorylase (PNPase) in the presence of zinc chlorideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50033666(2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methox...)
Affinity DataKi:  5.20nMAssay Description:Inhibition of purine nucleoside phosphorylase of human erythrocytes in xanthine oxidase-coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50042370(CHEMBL326595 | [3-(2-Amino-6-oxo-1,6-dihydro-purin...)
Affinity DataKi:  5.80nMAssay Description:Inhibition of purine nucleoside phosphorylase of human erythrocytes in xanthine oxidase-coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50042364(CHEMBL327010 | [2-(2-Amino-6-oxo-1,6-dihydro-purin...)
Affinity DataKi:  8.30nMAssay Description:Inhibition of purine nucleoside phosphorylase of human erythrocytes in xanthine oxidase-coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50033661(CHEMBL7247 | {[7-(2-Amino-6-oxo-1,6-dihydro-purin-...)
Affinity DataKi:  10nMAssay Description:Inhibition of human erythrocyte purine nucleoside phosphorylase (PNPase) in the presence of zinc chlorideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50033666(2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methox...)
Affinity DataKi:  11nMAssay Description:Inhibition of human erythrocyte purine nucleoside phosphorylase (PNPase) in the presence of ethylenediaminetetraacetic acid (Na2 EDTA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50042372(CHEMBL117127 | {3-[3-(2-Amino-6-oxo-1,6-dihydro-pu...)
Affinity DataKi:  13nMAssay Description:Inhibition of purine nucleoside phosphorylase of human erythrocytes in xanthine oxidase-coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50042363(CHEMBL333946 | {2-[2-(2-Amino-6-oxo-1,6-dihydro-pu...)
Affinity DataKi:  35nMAssay Description:Inhibition of purine nucleoside phosphorylase of human erythrocytes in xanthine oxidase-coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50042367(CHEMBL325716 | {3-[3-(2-Amino-6-oxo-1,6-dihydro-pu...)
Affinity DataKi:  60nMAssay Description:Inhibition of purine nucleoside phosphorylase of human erythrocytes in xanthine oxidase-coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50042369(CHEMBL119243 | {2-[3-(2-Amino-6-oxo-1,6-dihydro-pu...)
Affinity DataKi:  69nMAssay Description:Inhibition of purine nucleoside phosphorylase of human erythrocytes in xanthine oxidase-coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50033664(CHEMBL7068 | {[4-(2-Amino-6-oxo-1,6-dihydro-purin-...)
Affinity DataKi:  100nMAssay Description:Inhibition of human erythrocyte purine nucleoside phosphorylase (PNPase) in the presence of zinc chlorideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50042362(CHEMBL331133 | [2-(2-Amino-6-oxo-1,6-dihydro-purin...)
Affinity DataKi:  150nMAssay Description:Inhibition of purine nucleoside phosphorylase of human erythrocytes in xanthine oxidase-coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50033663(CHEMBL7319 | {[6-(2-Amino-6-oxo-1,6-dihydro-purin-...)
Affinity DataKi:  390nMAssay Description:Inhibition of human erythrocyte purine nucleoside phosphorylase (PNPase) in the presence of ethylenediaminetetraacetic acid (Na2 EDTA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50042366(CHEMBL116580 | [3-(2-Amino-6-oxo-1,6-dihydro-purin...)
Affinity DataKi:  600nMAssay Description:Inhibition of purine nucleoside phosphorylase of human erythrocytes in xanthine oxidase-coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50033660(CHEMBL269745 | {[5-(2-Amino-6-oxo-1,6-dihydro-puri...)
Affinity DataKi:  900nMAssay Description:Inhibition of human erythrocyte purine nucleoside phosphorylase (PNPase) in the presence of ethylenediaminetetraacetic acid (Na2 EDTA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50042361(CHEMBL324839 | {3-[2-(2-Amino-6-oxo-1,6-dihydro-pu...)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of purine nucleoside phosphorylase of human erythrocytes in xanthine oxidase-coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50033661(CHEMBL7247 | {[7-(2-Amino-6-oxo-1,6-dihydro-purin-...)
Affinity DataKi:  1.10E+3nMAssay Description:Inhibition of human erythrocyte purine nucleoside phosphorylase (PNPase) in the presence of ethylenediaminetetraacetic acid (Na2 EDTA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50033665(CHEMBL268378 | {[5-(2-Amino-6-oxo-1,6-dihydro-puri...)
Affinity DataKi:  1.10E+3nMAssay Description:Inhibition of human erythrocyte purine nucleoside phosphorylase (PNPase) in the presence of zinc chlorideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50033664(CHEMBL7068 | {[4-(2-Amino-6-oxo-1,6-dihydro-purin-...)
Affinity DataKi:  1.40E+3nMAssay Description:Inhibition of human erythrocyte purine nucleoside phosphorylase (PNPase) in the presence of ethylenediaminetetraacetic acid (Na2 EDTA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50033662(CHEMBL7194 | {Hydroxy-[5-(2-hydroxy-6-oxo-1,6-dihy...)
Affinity DataKi:  1.40E+3nMAssay Description:Inhibition of human erythrocyte purine nucleoside phosphorylase (PNPase) in the presence of zinc chlorideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistidine decarboxylase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50010139(CHEMBL54664 | L-Histidine Methyl Ester)
Affinity DataKi:  1.80E+3nMAssay Description:Inhibition of histidine decarboxylase in Sprague-Dawley rat stomach assessed as decrease in 14CO2 production using L-histidine-carboxyl-14C as substr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50042360(CHEMBL117588 | [4-(2-Amino-6-oxo-1,6-dihydro-purin...)
Affinity DataKi:  3.50E+3nMAssay Description:Inhibition of purine nucleoside phosphorylase of human erythrocytes in xanthine oxidase-coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50042368(CHEMBL446671 | [4-(2-Amino-6-oxo-1,6-dihydro-purin...)
Affinity DataKi:  7.00E+3nMAssay Description:Inhibition of purine nucleoside phosphorylase of human erythrocytes in xanthine oxidase-coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50033665(CHEMBL268378 | {[5-(2-Amino-6-oxo-1,6-dihydro-puri...)
Affinity DataKi:  1.40E+4nMAssay Description:Inhibition of human erythrocyte purine nucleoside phosphorylase (PNPase) in the presence of ethylenediaminetetraacetic acid (Na2 EDTA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50033662(CHEMBL7194 | {Hydroxy-[5-(2-hydroxy-6-oxo-1,6-dihy...)
Affinity DataKi:  2.70E+5nMAssay Description:Inhibition of human erythrocyte purine nucleoside phosphorylase (PNPase) in the presence of ethylenediaminetetraacetic acid (Na2 EDTA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50042371(CHEMBL327003 | [4-(2-Amino-6-oxo-1,6-dihydro-purin...)
Affinity DataKi:  2.70E+5nMAssay Description:Inhibition of purine nucleoside phosphorylase of human erythrocytes in xanthine oxidase-coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50007518((S)-3-chloro-5-ethyl-N-((1-ethylpyrrolidin-2-yl)me...)
Affinity DataIC50:  0.920nMAssay Description:Tested in vitro for inhibition of [3H]spiperone binding to dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50007534(3-Bromo-N-((S)-1-ethyl-pyrrolidin-2-ylmethyl)-2-hy...)
Affinity DataIC50:  12nMAssay Description:Tested in vitro for inhibition of [3H]spiperone binding to dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUridine phosphorylase 1(Mus musculus)
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50030972(5-(3-sec-Butoxy-benzyl)-1-(2-hydroxy-ethoxymethyl)...)
Affinity DataIC50:  27nMAssay Description:Inhibition of uridine phosphorylase (UrdPase) from murine liver.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUridine phosphorylase 1(Mus musculus)
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50031005(1-(2-Hydroxy-ethoxymethyl)-5-(3-propoxy-benzyl)-1H...)
Affinity DataIC50:  47nMAssay Description:Inhibition of uridine phosphorylase (UrdPase) from murine liver.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUridine phosphorylase 1(Mus musculus)
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50030974(1-(2-Hydroxy-1-hydroxymethyl-ethoxymethyl)-5-(3-pr...)
Affinity DataIC50:  60nMAssay Description:Inhibition of uridine phosphorylase (UrdPase) from murine liver.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUridine phosphorylase 1(Mus musculus)
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50031009(1-(2-Hydroxy-ethoxymethyl)-5-(3-isobutoxy-benzyl)-...)
Affinity DataIC50:  66nMAssay Description:Inhibition of uridine phosphorylase (UrdPase) from murine liver.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUridine phosphorylase 1(Mus musculus)
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50030990(5-[3-(3-Fluoro-propoxy)-benzyl]-1-(2-hydroxy-ethox...)
Affinity DataIC50:  68nMAssay Description:Inhibition of uridine phosphorylase (UrdPase) from murine liver.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUridine phosphorylase 1(Mus musculus)
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50030980(1-((2-HYDROXYETHOXY)METHYL)-5-(3-(BENZYLOXY)BENZYL...)
Affinity DataIC50:  84nMAssay Description:Inhibition of uridine phosphorylase (UrdPase) from murine liver.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUridine phosphorylase 1(Mus musculus)
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50031006(5-(3-Ethoxy-benzyl)-1-(2-hydroxy-ethoxymethyl)-1H-...)
Affinity DataIC50:  100nMAssay Description:Inhibition of uridine phosphorylase (UrdPase) from murine liver.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUridine phosphorylase 1(Mus musculus)
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50031007(5-[3-(3-Fluoro-propoxy)-benzyl]-1-(2-hydroxy-1-hyd...)
Affinity DataIC50:  110nMAssay Description:Inhibition of uridine phosphorylase (UrdPase) from murine liver.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUridine phosphorylase 1(Mus musculus)
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50030999(5-(3-Chloro-benzyl)-1-(2-hydroxy-1-hydroxymethyl-e...)
Affinity DataIC50:  110nMAssay Description:Inhibition of uridine phosphorylase (UrdPase) from murine liver.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUridine phosphorylase 1(Mus musculus)
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50030983(5-(3-Allyloxy-benzyl)-1-(2-hydroxy-ethoxymethyl)-1...)
Affinity DataIC50:  130nMAssay Description:Inhibition of uridine phosphorylase (UrdPase) from murine liver.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUridine phosphorylase 1(Mus musculus)
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50031004(1-(2-Hydroxy-ethoxymethyl)-5-(3-isopropoxy-benzyl)...)
Affinity DataIC50:  160nMAssay Description:Inhibition of uridine phosphorylase (UrdPase) from murine liver.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUridine phosphorylase 1(Mus musculus)
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50030995(5-(3-Butoxy-benzyl)-1-(2-hydroxy-ethoxymethyl)-1H-...)
Affinity DataIC50:  160nMAssay Description:Inhibition of uridine phosphorylase (UrdPase) from murine liver.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50122955(2-(4,6-Difluoro-indan-1-ylidene)-acetamide | CHEMB...)
Affinity DataIC50:  200nMAssay Description:Inhibitory concentration of the compound against Monoamine oxidase B (MAO-B)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM11638(CHEMBL26 | Compound 7 | N-[(1-ethylpyrrolidin-2-yl...)
Affinity DataIC50:  210nMAssay Description:Tested in vitro for inhibition of [3H]spiperone binding to dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUridine phosphorylase 1(Mus musculus)
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50030984(5-(3-Chloro-benzyl)-1-(2-hydroxy-ethoxymethyl)-1H-...)
Affinity DataIC50:  300nMAssay Description:Inhibition of uridine phosphorylase (UrdPase) from murine liver.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUridine phosphorylase 1(Mus musculus)
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50030981(5-(3,5-Difluoro-benzyl)-1-(2-hydroxy-ethoxymethyl)...)
Affinity DataIC50:  350nMAssay Description:Inhibition of uridine phosphorylase (UrdPase) from murine liver.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUridine phosphorylase 1(Mus musculus)
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50026387(1-((2-HYDROXYETHOXY)METHYL)-5-BENZYLPYRIMIDINE-2,4...)
Affinity DataIC50:  460nMAssay Description:Inhibition of uridine phosphorylase (UrdPase) from murine liver.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUridine phosphorylase 1(Mus musculus)
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50030976(5-(3-Fluoro-benzyl)-1-(2-hydroxy-ethoxymethyl)-1H-...)
Affinity DataIC50:  550nMAssay Description:Inhibition of uridine phosphorylase (UrdPase) from murine liver.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005520((S)-2-{4-[3-(2,4-Diamino-6-oxo-1,6-dihydro-pyrimid...)
Affinity DataIC50:  700nMAssay Description:Inhibition activity against Glycinamide ribonucleotide transformylase(GAR-TFase) against hog liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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