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Found 1721 with Last Name = 'marchand' and Initial = 'c'
TargetTyrosyl-DNA phosphodiesterase 1(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50388546(CHEMBL213072 | CHEMBL333363)
Affinity DataKi:  3.19E+3nMAssay Description:Competitive inhibition of human recombinant Tdp1 after 1 hr by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADH](Francisella tularensis subsp. tularensis (strain S...)
Naval Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50436715(CHEMBL2398661)
Affinity DataKi:  3.40E+3nMAssay Description:Competitive inhibition of C-terminal His6-tagged Francisella tularensis SCHU S4 FabI expressed in Escherichia coli BL21 (DE3) using CrCoA as substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADH](Francisella tularensis subsp. tularensis (strain S...)
Naval Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50436718(CHEMBL1341978)
Affinity DataKi:  7.00E+3nMAssay Description:Competitive inhibition of C-terminal His6-tagged Francisella tularensis SCHU S4 FabI expressed in Escherichia coli BL21 (DE3) using CrCoA as substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Universit£

Curated by ChEMBL
LigandPNGBDBM25351(N-[2-(4-{[(4-fluorophenyl)methyl]carbamoyl}-5-hydr...)
Affinity DataIC50:  7nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity by gel-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Universit£

Curated by ChEMBL
LigandPNGBDBM25351(N-[2-(4-{[(4-fluorophenyl)methyl]carbamoyl}-5-hydr...)
Affinity DataIC50:  7nMAssay Description:Inhibition of strand transfer activity of recombinant HIV1 integrase using 5'-end-labeled 21-mer double-stranded DNA as substrate after 60 mins by el...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50020284(CHEMBL3288833)
Affinity DataIC50:  8.20nMAssay Description:Inhibition of strand transfer activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50020294(CHEMBL3288834)
Affinity DataIC50:  8.40nMAssay Description:Inhibition of strand transfer activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Universit£

Curated by ChEMBL
LigandPNGBDBM50498306(CHEMBL3582062)
Affinity DataIC50:  10nMAssay Description:Inhibition of HIV-1 integrase assessed as inhibition of strand transfer activity using 32P-labeled DNA as substrate after 1 hr by gel-based assay in ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50020278(CHEMBL3288827)
Affinity DataIC50:  10nMAssay Description:Inhibition of strand transfer activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50020283(CHEMBL3288832)
Affinity DataIC50:  10nMAssay Description:Inhibition of strand transfer activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Universit£

Curated by ChEMBL
LigandPNGBDBM50123468(CHEMBL32865 | [3-Benzyl-5-(1,1-dioxo-1lambda 6 -is...)
Affinity DataIC50:  10nMAssay Description:Inhibition of recombinant HIV1 integrase strand transfer activity by high throughput electrochemiluminescent assay in presence of magnesiumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Universit£

Curated by ChEMBL
LigandPNGBDBM50479082(CHEMBL497501)
Affinity DataIC50:  12nMAssay Description:Inhibition of HIV-1 integrase assessed as inhibition of strand transfer activity using 32P-labeled DNA as substrate after 1 hr by gel-based assay in ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50184349((Z)-4-[6-((Z)-3-carboxy-3-hydroxy-acryloyl)-1-(4-f...)
Affinity DataIC50:  12nMAssay Description:Inhibition of HIV1 integrase strand transfer activity in presence of MnCl2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Universit£

Curated by ChEMBL
LigandPNGBDBM25351(N-[2-(4-{[(4-fluorophenyl)methyl]carbamoyl}-5-hydr...)
Affinity DataIC50:  13nMAssay Description:Inhibition of recombinant HIV-1 integrase stand transfer activity expressed in Escherichia coli BL21(DE3) cells using 32P-labeled DNA substrate after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50020307(CHEMBL3288835)
Affinity DataIC50:  13nMAssay Description:Inhibition of strand transfer activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Universit£

Curated by ChEMBL
LigandPNGBDBM50496325(CHEMBL3125979)
Affinity DataIC50:  14nMAssay Description:Inhibition of HIV-1 integrase-mediated strand transfer activity using [32P]-labeled oligonucleotide as substrate after 2 hrs by densitometric analysi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Universit£

Curated by ChEMBL
LigandPNGBDBM50486615(CHEMBL2236599)
Affinity DataIC50:  15nMAssay Description:Inhibition of HIV-1 integrase assessed as inhibition of strand transfer activity using 32P-labeled DNA as substrate after 1 hr by gel-based assay in ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50184349((Z)-4-[6-((Z)-3-carboxy-3-hydroxy-acryloyl)-1-(4-f...)
Affinity DataIC50:  16nMAssay Description:Inhibition of HIV1 integrase strand transfer activity in presence of MgCl2 by plate-based electrochemiluminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Universit£

Curated by ChEMBL
LigandPNGBDBM50479082(CHEMBL497501)
Affinity DataIC50:  16nMAssay Description:Inhibition of recombinant HIV1 integrase strand transfer activity by high throughput electrochemiluminescent assay in presence of magnesiumMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50020276(CHEMBL3288825)
Affinity DataIC50:  16nMAssay Description:Inhibition of strand transfer activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Universit£

Curated by ChEMBL
LigandPNGBDBM50498303(CHEMBL3582057)
Affinity DataIC50:  16nMAssay Description:Inhibition of HIV-1 integrase assessed as inhibition of strand transfer activity using 32P-labeled DNA as substrate after 1 hr by gel-based assay in ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Universit£

Curated by ChEMBL
LigandPNGBDBM50496313(CHEMBL3125980)
Affinity DataIC50:  17nMAssay Description:Inhibition of HIV-1 integrase-mediated strand transfer activity using [32P]-labeled oligonucleotide as substrate after 2 hrs by densitometric analysi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50020281(CHEMBL3288830)
Affinity DataIC50:  17nMAssay Description:Inhibition of strand transfer activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50184349((Z)-4-[6-((Z)-3-carboxy-3-hydroxy-acryloyl)-1-(4-f...)
Affinity DataIC50:  17nMAssay Description:Inhibition of HIV1 integrase strand transfer activity in presence of MgCl2 by gel-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Universit£

Curated by ChEMBL
LigandPNGBDBM50479082(CHEMBL497501)
Affinity DataIC50:  17nMAssay Description:Inhibition of recombinant HIV1 integrase strand transfer activity by gel-based assay in presence of magnesiumMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Universit£

Curated by ChEMBL
LigandPNGBDBM50498284(CHEMBL3582070)
Affinity DataIC50:  18nMAssay Description:Inhibition of HIV-1 integrase assessed as inhibition of strand transfer activity using 32P-labeled DNA as substrate after 1 hr by gel-based assay in ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Universit£

Curated by ChEMBL
LigandPNGBDBM50479098(CHEMBL498698)
Affinity DataIC50:  18nMAssay Description:Inhibition of recombinant HIV1 integrase strand transfer activity by high throughput electrochemiluminescent assay in presence of magnesiumMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50020259(CHEMBL3288817)
Affinity DataIC50:  18nMAssay Description:Inhibition of strand transfer activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Universit£

Curated by ChEMBL
LigandPNGBDBM50479086(CHEMBL497688)
Affinity DataIC50:  19nMAssay Description:Inhibition of recombinant HIV1 integrase strand transfer activity by high throughput electrochemiluminescent assay in presence of magnesiumMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Universit£

Curated by ChEMBL
LigandPNGBDBM50486614(RDS-1984)
Affinity DataIC50:  19nMAssay Description:Inhibition of HIV-1 integrase assessed as inhibition of strand transfer activity using 32P-labeled DNA as substrate after 1 hr by gel-based assay in ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50020309(CHEMBL3288837)
Affinity DataIC50:  19nMAssay Description:Inhibition of strand transfer activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Universit£

Curated by ChEMBL
LigandPNGBDBM50076169(CHEMBL3415853)
Affinity DataIC50:  19nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity by gel-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Universit£

Curated by ChEMBL
LigandPNGBDBM50479087(CHEMBL498697)
Affinity DataIC50:  20nMAssay Description:Inhibition of recombinant HIV1 integrase strand transfer activity by high throughput electrochemiluminescent assay in presence of magnesiumMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50020280(CHEMBL3288829)
Affinity DataIC50:  21nMAssay Description:Inhibition of strand transfer activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Universit£

Curated by ChEMBL
LigandPNGBDBM50076179(CHEMBL3415843)
Affinity DataIC50:  22nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity by gel-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50020267(CHEMBL3288824)
Affinity DataIC50:  24nMAssay Description:Inhibition of strand transfer activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Universit£

Curated by ChEMBL
LigandPNGBDBM50076177(CHEMBL3415845)
Affinity DataIC50:  24nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity by gel-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosyl-DNA phosphodiesterase 2(Homo sapiens (Human))
National Institutes Of Health

LigandPNGBDBM188529(2,4-Dioxo-10-[3-(1H-tetrazol-5-yl)phenyl]pyrimido[...)
Affinity DataIC50:  25nMpH: 7.5Assay Description:Ten-million cells (1 x 107), either human, chicken DT40 wild type, or knockout for TDP2 and complemented with human TDP2, were collected, washed, and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Universit£

Curated by ChEMBL
LigandPNGBDBM50142736((E)-6-[1-(4-Fluoro-benzyl)-1H-pyrrol-2-yl]-2,4-dio...)
Affinity DataIC50:  26nMAssay Description:Inhibition of strand transfer activity of recombinant HIV1 integrase using 5'-end-labeled 21-mer double-stranded DNA as substrate after 60 mins by el...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50020260(CHEMBL3288818)
Affinity DataIC50:  27nMAssay Description:Inhibition of strand transfer activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Universit£

Curated by ChEMBL
LigandPNGBDBM50496319(CHEMBL3125970)
Affinity DataIC50:  27nMAssay Description:Inhibition of HIV-1 integrase-mediated strand transfer activity using [32P]-labeled oligonucleotide as substrate after 2 hrs by densitometric analysi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50020282(CHEMBL3288831)
Affinity DataIC50:  27nMAssay Description:Inhibition of strand transfer activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50020279(CHEMBL3288828)
Affinity DataIC50:  27nMAssay Description:Inhibition of strand transfer activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50183273((S)-6-(3-chloro-2-fluorobenzyl)-1-(1-hydroxy-3-met...)
Affinity DataIC50:  28nMAssay Description:Inhibition of HIV1 integrase strand transfer activity by gel-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetIntegrase(Human immunodeficiency virus 1)
Universit£

Curated by ChEMBL
LigandPNGBDBM50183273((S)-6-(3-chloro-2-fluorobenzyl)-1-(1-hydroxy-3-met...)
Affinity DataIC50:  28nMAssay Description:Inhibition of HIV-1 integrase assessed as inhibition of strand transfer activity using 32P-labeled DNA as substrate after 1 hr by gel-based assay in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Universit£

Curated by ChEMBL
LigandPNGBDBM50479097(CHEMBL496652)
Affinity DataIC50:  28nMAssay Description:Inhibition of recombinant HIV1 integrase strand transfer activity by high throughput electrochemiluminescent assay in presence of magnesiumMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Universit£

Curated by ChEMBL
LigandPNGBDBM50479084(CHEMBL496454)
Affinity DataIC50:  28nMAssay Description:Inhibition of recombinant HIV1 integrase strand transfer activity by high throughput electrochemiluminescent assay in presence of magnesiumMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM188529(2,4-Dioxo-10-[3-(1H-tetrazol-5-yl)phenyl]pyrimido[...)
Affinity DataIC50:  29nMpH: 7.5Assay Description:TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Universit£

Curated by ChEMBL
LigandPNGBDBM50479096(CHEMBL498713)
Affinity DataIC50:  33nMAssay Description:Inhibition of recombinant HIV1 integrase strand transfer activity by high throughput electrochemiluminescent assay in presence of magnesiumMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Universit£

Curated by ChEMBL
LigandPNGBDBM50479096(CHEMBL498713)
Affinity DataIC50:  33nMAssay Description:Inhibition of HIV-1 integrase assessed as inhibition of strand transfer activity using 32P-labeled DNA as substrate after 1 hr by gel-based assay in ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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